DRSC/TRiP Functional Genomics Resources

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Protein Alignment nompC and trp-4

DIOPT Version :9

Sequence 1:NP_523483.2 Gene:nompC / 33768 FlyBaseID:FBgn0016920 Length:1761 Species:Drosophila melanogaster
Sequence 2:NP_493429.2 Gene:trp-4 / 190574 WormBaseID:WBGene00006616 Length:1924 Species:Caenorhabditis elegans


Alignment Length:1742 Identity:727/1742 - (41%)
Similarity:1027/1742 - (58%) Gaps:147/1742 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 PPDESATPSERATPASKADSDPKDDSSSNGDKKDMDLFPAPKPPSAGASIRDTANKVLGLAMKSE 91
            |..:|.||.:|..............:||:.:....||           ::.|...|:|..|.:.|
 Worm   277 PSRDSVTPPDRLLGKPLFRESLTSHASSHEEMSSEDL-----------AMADPQTKILYFAKRDE 330

  Fly    92 WTPIEAELKKLEKYVANVGEDGNHIPLAGVHDMNTGMTPLMYATKDNKTAIMDRMIELGADVGAR 156
            |..:|:|::.:::...::.:  ||           |.|..:.|.|..|..|:|:||..||.|...
 Worm   331 WANVESEIETIKRSDFSMAD--NH-----------GFTAFLLAVKAGKDQIVDKMIRKGARVDYS 382

  Fly   157 NNDNYNVLHIAAMYSREDVVKLLLTKRGVDPFSTG-GSRSQTAVHLVSSRQTGTATNILRALLAA 220
            ..|..|..|||||||..:.::|:| ||..:....| |.:.|.|:|:...|::..|..|::.:|  
 Worm   383 TKDGRNATHIAAMYSGVETLELIL-KRYSELLRKGAGPKKQLAIHVACERKSKKAFPIVKRIL-- 444

  Fly   221 AGKDIRLKADGRGKIPLLLAVESGNQSMCRELLAAQTAEQLKATTANGDTALHLAARRRDVDMVR 285
            ...|.|:..||.|.:|:.||.:.||.::...||:..:.||.:....||||.||||||..:::.||
 Worm   445 EDTDQRMAEDGDGSLPIHLAFKFGNVNIVELLLSGPSDEQTRKADGNGDTLLHLAARSGNIEAVR 509

  Fly   286 ILVDYG-TNVDTQNGEGQTPLHIAAAEGDEALLKYFYGVRASASIADNQDRTPMHLAAENGHAHV 349
            ..:..| .|.:.||..|:||||..|..||:.:||..:.:||.|:|.|.:|:||:|:|||.|...:
 Worm   510 TAIAAGCDNANVQNRVGRTPLHEVAEVGDQNMLKIMFKLRADANIHDKEDKTPVHVAAERGDTSM 574

  Fly   350 IEILADKFKASIFERTKDGSTLMHIASLNGHAECATMLFKKGVYLHMPNKDGARSIHTAAAYGHT 414
            :|.|.|||..||..||:|||||:|||:.:||...|....|:||.|.||||.||..:|:|||.|..
 Worm   575 VESLIDKFGGSIRARTRDGSTLLHIAACSGHTSTALAFLKRGVPLFMPNKKGALGLHSAAAAGFN 639

  Fly   415 GIINTLLQKGEKVDVTTNDNYTALHIAVESAKPAVVETLLGFGADVHVRGGKLRETPLHIAARVK 479
            .::..|:.:|..|||.|.|||||||:||:|.|.:|||||||.|||:||:||:|.:|.|||||.:.
 Worm   640 DVVKMLIARGTNVDVRTRDNYTALHVAVQSGKASVVETLLGSGADIHVKGGELGQTALHIAASLN 704

  Fly   480 DGDR--CALMLLKSGASPNLTTDDCLTPVHVAARHGNLATLMQLLEDEGDPLYKSNTGETPLHMA 542
            ..:.  ||:||||||..|::...|..|.:|:|||.||...:..||::..|....|..|||||.:|
 Worm   705 GAESRDCAMMLLKSGGQPDVAQMDGETCLHIAARSGNKDIMRLLLDENADSKISSKIGETPLQVA 769

  Fly   543 CRACHPD----IVRHLIETVKEKHGPDKATTYINSVNEDGATALHYTCQITKEEVKIPESDKQIV 603
            .::|:.:    |::||.|.:.:    ::...::|....||.|||||..:|.:.::..|..|.::|
 Worm   770 AKSCNFEAASMILKHLSEVLTQ----EQLKEHVNHRTNDGFTALHYAAEIEQRQLHFPGEDAKLV 830

  Fly   604 RMLLENGADVTLQTKTALETAFHYCAVAGNNDVLMEMISHMNPTDIQKAMNRQSSVGWTPLLIAC 668
            .:|::.|..|.:.:..|.|||.|..|.:||..||:.|::.:....:|...|:||..||:|||.||
 Worm   831 NLLIDYGGMVEMPSLNANETAMHMAARSGNQAVLLAMVNKIGAGAVQIVQNKQSKNGWSPLLEAC 895

  Fly   669 HRGHMELVNNLLANHARVDVFDTEGRSALHLAAERGYLHVCDALLTNKAFINSKSRVGRTALHLA 733
            .|||..:.|.||.:|||:||||..||:||||||..|:|.:...||.:|||:||||:.|...||||
 Worm   896 ARGHSGVANILLKHHARIDVFDEMGRTALHLAAFNGHLSLVHLLLQHKAFVNSKSKTGEAPLHLA 960

  Fly   734 AMNGFTHLVKFLIKDHNAVIDILTLRKQTPLHLAAASGQMEVCQLLLELGANIDATDDLGQKPIH 798
            |.:|...:|..|::||.|.::.:||..||.||.||..||:.|.|.||.||||.:|.||.||.|:|
 Worm   961 AQHGHVKVVNVLVQDHGAALEAITLDNQTALHFAAKFGQLAVSQTLLALGANPNARDDKGQTPLH 1025

  Fly   799 VAAQNNYSEVAKLFLQ---QHPSLVNATSKDGNTCAHIAAMQGSVKVIEELMKFDRSGVISARNK 860
            :||:|::.:|.||||:   .:.|::.|...:|.||||||||:||:.|:.|||..|:..||.|:.|
 Worm  1026 LAAENDFPDVVKLFLKMRNNNRSVLTAIDHNGFTCAHIAAMKGSLAVVRELMMIDKPMVIQAKTK 1090

  Fly   861 LTDATPLQLAAEGGHADVVKALVRAGASCTEENKAGFTAVHLAAQNGHGQVLDVLKSTNSLRINS 925
            ..:||.|.:||.||||::||.|:..||:..:||..|.||:||.|:||...:|:........|. |
 Worm  1091 TLEATTLHMAAAGGHANIVKILLENGANAEDENSHGMTALHLGAKNGFISILEAFDKILWKRC-S 1154

  Fly   926 KKLGLTPLHVAAYYGQADTVRELLTSVPATVKSETPT-GQSLFGDLGTESGMTPLHLAAFSGNEN 989
            :|.||..||:||:||.:|.|.|:|..|.|||:||.|. ...:..:..||.|.|||||||.||:::
 Worm  1155 RKTGLNALHIAAFYGNSDFVNEMLKHVQATVRSEPPIYNHHVNKEFSTEYGFTPLHLAAQSGHDS 1219

  Fly   990 VVRLLLNSAGVQVDAATIENGYNPLHLACFGGHMSVVGLLLSRSAELLQSQDRNGRTGLHIAAMH 1054
            :||:|||. ||||||.:......|||||...||::|||:|||||.:...::|..|||.||:||.:
 Worm  1220 LVRMLLNQ-GVQVDATSTTMNVIPLHLAAQQGHIAVVGMLLSRSTQQQHAKDWRGRTPLHLAAQN 1283

  Fly  1055 GHIQMVEILLGQGAEINATDRNGWTPLHCAAKAGHLEVVKLLCEAGASPKSETNYGCAAIWFAAS 1119
            ||.:||.:|:.||:.||..|:||||.||.|.:||||.||||..::.|.|.:||..|...:.|||:
 Worm  1284 GHYEMVSLLIAQGSNINVMDQNGWTGLHFATRAGHLSVVKLFIDSSADPLAETKEGKVPLCFAAA 1348

  Fly  1120 EGHNEVLRYLMNKEHDTYGLMEDKRFVYNLMVVSKNHNNKPIQEFVLVSPAPVDTAAKLSNIYIV 1184
            ..|.|.||:|:.::|||:.||||::|:::|||..|.::|:|:|||:|.||||::||.|||.:|..
 Worm  1349 HNHIECLRFLLKQKHDTHQLMEDRKFIFDLMVCGKTNDNEPLQEFILQSPAPIETAVKLSALYRD 1413

  Fly  1185 LSTKEKERAKDLVAAGKQCEAMATELLALAAGSDSAGKILQATDKRNVEFLDVLIENEQKEVIAH 1249
            :|.|||||||||:......|.||.|||.:.|...:|..:|:|.|.|....||||||||||||:::
 Worm  1414 MSEKEKERAKDLLNVAVFSENMAVELLGITATEYNAALLLKAKDNRGRPLLDVLIENEQKEVVSY 1478

  Fly  1250 TVVQRYLQELWHGSLTWASWKILLLLVAFIVCPPVWIGFTFPMGHKFNKVPIIKFMSYLTSHIYL 1314
            ..|||||.|:|...:.|:..|.:...:..::|||.|..|:.|:..:..:.|||||:.::.||:|.
 Worm  1479 ASVQRYLTEVWTARVDWSFGKFVAFSLFVLICPPAWFYFSLPLDSRIGRAPIIKFVCHIVSHVYF 1543

  Fly  1315 MIHLSIV--GIT-PIYPVLRLSLVPYWYEVGLLIWLSGLLLFELTNPSDKSGLGSIKVLVLLLGM 1376
            .|.|:||  .|| .:|.|  .|:||...|..||:||||.|:.||:.....||||.:|||:|:|..
 Worm  1544 TILLTIVVLNITHKMYEV--TSVVPNPVEWLLLLWLSGNLVSELSTVGGGSGLGIVKVLILVLSA 1606

  Fly  1377 AGVGVHVSAFL----FVSK-------EYWPTLVYCRNQCFALAFLLACVQILDFLSFHHLFGPWA 1430
            ..:.|||.|||    |::.       .:..|::|.:||.||.|.|.|.|:.||||:.||||||||
 Worm  1607 MAIAVHVLAFLLPAVFLTHLDNDEKLHFARTMLYLKNQLFAFALLFAFVEYLDFLTVHHLFGPWA 1671

  Fly  1431 IIIGDLLKDLARFLAVLAIFVFGFSMHIVALNQSFANFSPEDLRSFEKKNRNRGYFSDDDMPTPR 1495
            |||.||:.||||||.:|.:||.||::|:.::.|                            |..:
 Worm  1672 IIIRDLMYDLARFLVILMLFVAGFTLHVTSIFQ----------------------------PAYQ 1708

  Fly  1496 PPPVENYVDSRFSEFRRKHKDDLRMHPINSFELLFFAVFGQTTTEQTQVDKIKNVATPTQPYWVE 1560
            |      ||...:|..|      ...|..:.|:|||::||  ..|...:..:..|     |.:.:
 Worm  1709 P------VDEDSAELMR------LASPSQTLEMLFFSLFG--LVEPDSMPPLHLV-----PDFAK 1754

  Fly  1561 YLFKIVFGIYMLVSVVVLINLLIAMMSDTYQRIQAQSDIEWKFGLSKLIRNMHRTTTAPSPLNLV 1625
            .:.|::|||||:|:::||||||||||||||||||||||.|||||.:.|||.|::.:..|||:|::
 Worm  1755 IILKLLFGIYMMVTLIVLINLLIAMMSDTYQRIQAQSDKEWKFGRAILIRQMNKKSATPSPINML 1819

  Fly  1626 TTWFMWIVEKVKAR-----MKKKKRPSL--------VQMMGIRQA--SPRTKAGAKWLSKIKKDS 1675
            |.  :.||.:|..|     |.:|.:..|        ..|.|.:|.  || |..|.:         
 Worm  1820 TK--LIIVLRVAWRNRLRCMTRKAQDDLRFEENIDAFSMGGGQQGRQSP-TNEGRE--------- 1872

  Fly  1676 VALSQVHLSPLGSQASFSQANQNRIENVADWEAIAKKYRALVGDEEGGSLKD 1727
                       |.|...:.|:.| ||.|.||..|...|....|....|..|:
 Worm  1873 -----------GQQELGNSADWN-IETVIDWRKIVSMYYQANGKLTDGRTKE 1912

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nompCNP_523483.2 ANK repeat 129..157 CDD:293786 11/27 (41%)
Ank_2 131..228 CDD:289560 34/97 (35%)
ANK 155..319 CDD:238125 61/165 (37%)
ANK repeat 159..186 CDD:293786 13/26 (50%)
ANK repeat 232..265 CDD:293786 10/32 (31%)
Ank_2 237..331 CDD:289560 38/94 (40%)
ANK 263..387 CDD:238125 59/124 (48%)
ANK repeat 267..298 CDD:293786 14/31 (45%)
ANK repeat 300..331 CDD:293786 14/30 (47%)
Ank_2 305..398 CDD:289560 45/92 (49%)
ANK 329..454 CDD:238125 66/124 (53%)
ANK repeat 367..398 CDD:293786 16/30 (53%)
ANK repeat 400..431 CDD:293786 12/30 (40%)
Ank_2 405..498 CDD:289560 52/94 (55%)
ANK 428..555 CDD:238125 65/132 (49%)
ANK repeat 433..463 CDD:293786 22/29 (76%)
ANK repeat 469..499 CDD:293786 15/31 (48%)
ANK 496..641 CDD:238125 48/148 (32%)
ANK repeat 501..532 CDD:293786 11/30 (37%)
Ank_2 507..616 CDD:289560 36/112 (32%)
ANK repeat 534..575 CDD:293786 12/44 (27%)
ANK repeat 577..616 CDD:293786 14/38 (37%)
Ank_2 625..722 CDD:289560 47/96 (49%)
ANK 654..780 CDD:238125 66/125 (53%)
ANK repeat 660..690 CDD:293786 18/29 (62%)
ANK repeat 692..723 CDD:293786 17/30 (57%)
Ank_2 697..790 CDD:289560 47/92 (51%)
ANK 720..847 CDD:238125 64/129 (50%)
ANK repeat 725..757 CDD:293786 12/31 (39%)
ANK repeat 759..790 CDD:293786 17/30 (57%)
Ank_5 779..834 CDD:290568 28/57 (49%)
ANK 787..915 CDD:238125 62/130 (48%)
ANK repeat 792..824 CDD:293786 14/34 (41%)
ANK repeat 861..893 CDD:293786 14/31 (45%)
Ank_4 865..915 CDD:290365 24/49 (49%)
Ank_4 929..995 CDD:290365 33/66 (50%)
ANK repeat 932..972 CDD:293786 17/40 (43%)
ANK 969..1096 CDD:238125 70/126 (56%)
ANK repeat 974..1007 CDD:293786 21/32 (66%)
Ank_2 979..1074 CDD:289560 50/94 (53%)
ANK repeat 1009..1041 CDD:293786 15/31 (48%)
ANK 1039..1159 CDD:238125 58/119 (49%)
ANK repeat 1043..1074 CDD:293786 16/30 (53%)
Ank_2 1048..1135 CDD:289560 42/86 (49%)
ANK repeat 1076..1101 CDD:293786 15/24 (63%)
ANK repeat 1109..1134 CDD:293786 9/24 (38%)
Ion_trans <1393..1598 CDD:278921 83/204 (41%)
trp-4NP_493429.2 ANK repeat 804..842 CDD:293786 14/37 (38%)
ANK repeat 849..884 CDD:293786 12/34 (35%)
ANK repeat 886..917 CDD:293786 18/30 (60%)
ANK repeat 919..950 CDD:293786 17/30 (57%)
ANK repeat 952..982 CDD:293786 12/29 (41%)
ANK repeat 986..1017 CDD:293786 17/30 (57%)
PHA03095 1006..>1336 CDD:222980 163/331 (49%)
ANK repeat 1092..1123 CDD:293786 14/30 (47%)
ANK repeat 1204..1236 CDD:293786 21/32 (66%)
trp 1209..1879 CDD:273311 316/742 (43%)
ANK repeat 1238..1270 CDD:293786 15/31 (48%)
ANK repeat 1272..1303 CDD:293786 16/30 (53%)
ANK repeat 1305..1336 CDD:293786 17/30 (57%)
ANK repeat 1338..1366 CDD:293786 11/27 (41%)
ANKYR 280..515 CDD:223738 78/261 (30%)
ANK repeat 352..383 CDD:293786 13/41 (32%)
ANK repeat 385..418 CDD:293786 14/33 (42%)
ANK repeat 424..454 CDD:293786 8/31 (26%)
PHA03095 430..>756 CDD:222980 150/327 (46%)
ANK repeat 456..489 CDD:293786 10/32 (31%)
ANK repeat 491..523 CDD:293786 14/31 (45%)
ANK repeat 526..556 CDD:293786 14/29 (48%)
ANK repeat 558..590 CDD:293786 15/31 (48%)
ANK repeat 592..623 CDD:293786 16/30 (53%)
ANK repeat 625..656 CDD:293786 12/30 (40%)
ANK repeat 658..688 CDD:293786 22/29 (76%)
ANK repeat 692..726 CDD:293786 16/33 (48%)
PHA02876 <712..>1040 CDD:165207 143/331 (43%)
ANK repeat 728..753 CDD:293786 10/24 (42%)
ANK repeat 761..802 CDD:293786 12/44 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160158718
Domainoid 1 1.000 181 1.000 Domainoid score I2079
eggNOG 1 0.900 - - E1_KOG3609
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H101822
Inparanoid 1 1.050 1223 1.000 Inparanoid score I88
Isobase 1 0.950 - 0 Normalized mean entropy S5000
OMA 1 1.010 - - QHG46625
OrthoDB 1 1.010 - - D1115202at2759
OrthoFinder 1 1.000 - - FOG0009315
OrthoInspector 1 1.000 - - oto20004
orthoMCL 1 0.900 - - OOG6_107793
Panther 1 1.100 - - LDO PTHR24121
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1759
SonicParanoid 1 1.000 - - X100
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1817.750

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