DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nompC and unc-44

DIOPT Version :9

Sequence 1:	NP_523483.2	Gene:	nompC / 33768	FlyBaseID:	FBgn0016920	Length:	1761	Species:	Drosophila melanogaster
Sequence 2:	NP_001367345.1	Gene:	unc-44 / 177366	WormBaseID:	WBGene00006780	Length:	6994	Species:	Caenorhabditis elegans

Alignment Length:	1096	Identity:	293/1096 - (26%)
Similarity:	455/1096 - (41%)	Gaps:	244/1096 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 PFSTGGSRSQTAVHLVSSRQTGTATNILRALLAAAGKDIRLKADGRGKIPLLLAVESGNQSMCRE 251
            |.:....|::.:...:.:.:.|....:|.  |..||.||. .::..|...|.||.:.|:..:.||
Worm    23 PAAPEPGRAEGSASFLRAARAGDLEKVLE--LLRAGTDIN-TSNANGLNSLHLASKEGHSEVVRE 84

  Fly   252 LLAAQTAEQLKATTANGDTALHLAARRRDVDMVRILVDYGTNVDTQNGEGQTPLHIAAAEGDEAL 316
            |:..|.  |:.|.|..|:||||:|:......:|.|||:.|.||:.|:..|.|||::||.|..|.:
Worm    85 LIKRQA--QVDAATRKGNTALHIASLAGQSLIVTILVENGANVNVQSVNGFTPLYMAAQENHEEV 147

  Fly   317 LKYFYGVRASASIADNQDRTPMHLAAENGHAHVIEILADKFKASIFERTKDGST---LMHIASLN 378
            :||.....|:.:::.....||:.:|.:.||..|:.:|        .|....|..   .:|||:..
Worm   148 VKYLLKHGANQALSTEDGFTPLAVALQQGHDRVVAVL--------LENDSKGKVRLPALHIAAKK 204

  Fly   379 GHAECATMLFKKGVYLHMPNKDGARSIHTAAAYGHTGIINTLLQKGEKVDVTTNDNYTALHIAVE 443
            .....||:|.:......:.:|.|...:|.||.|||..:...||:||..|:.....|.:.||:|.:
Worm   205 DDTTAATLLLQNEHNPDVTSKSGFTPLHIAAHYGHENVGQLLLEKGANVNYQARHNISPLHVATK 269

  Fly   444 SAKPAVVETLLGFGADVHVRGGKLRETPLHIAARVKDGDRCALMLLKSGASPNLTTDDCLTPVHV 508
            ..:..:...||..||.:..|                                   |.|.|||:|.
Worm   270 WGRTNMANLLLSRGAIIDSR-----------------------------------TKDLLTPLHC 299

  Fly   509 AARHGNLATLMQLLEDEGDPL-YKSNTGETPLHMACRACHPDIVRHLIETVKEKHGPDKATTYIN 572
            |||.|: ..::.||..:|.|: .|:..|..|||||.:..|.|..|.|:
Worm   300 AARSGH-DQVVDLLVVQGAPISAKTKNGLAPLHMAAQGDHVDAARTLL----------------- 346

  Fly   573 SVNEDGATALHYTCQITKEEVKIPESDKQIVRMLLENGADVTLQTKTALETAFHYCAVAGNNDVL 637
                                                                :|...|   :||.
Worm   347 ----------------------------------------------------YHRAPV---DDVT 356

  Fly   638 MEMISHMNPTDIQKAMNRQSSVGWTPLLIACHRGHMELVNNLLANHARVDVFDTEGRSALHLAAE 702
            ::.:                    |||.:|.|.||:.:...||...|..:.....|.:.||:|.:
Worm   357 VDYL--------------------TPLHVAAHCGHVRVAKLLLDRSADPNSRALNGFTPLHIACK 401

  Fly   703 RGYLHVCDALLTNKAFINSKSRVGRTALHLAAMNGFTHLVKFLIKDHNAVIDILTLRKQTPLHLA 767
            :..:.|.:.||..:|.|.:.:..|.|.||:||..|..::|.:|:: ..|..|:.|:|.:||||||
Worm   402 KNRIKVVELLLKYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQ-QGANPDVETVRGETPLHLA 465

  Fly   768 AASGQMEVCQLLLELGANIDATDDLGQKPIHVAAQNNYSEVAKLFLQQHPSLVNATSKDGNTCAH 832
            |.:.|.:|.::|:..||.:||.....|.|:|:|::...:::..|.||...: .|||::|..:..|
Worm   466 ARANQTDVVRVLIRNGAKVDAQARELQTPLHIASRLGNTDIVILLLQAGAN-SNATTRDNYSPLH 529

  Fly   833 IAAMQGSVKVIEELMKFDRSGVISARNKLTDATPLQLAAEGGHADVVKALVRAGASCTEENKAGF 897
            |||.:|..:|...|:..:....:..:...   |||.||::.|:.:||:.|:..|
Worm   530 IAAKEGQEEVAGILLDHNADKTLLTKKGF---TPLHLASKYGNLEVVRLLLERG----------- 580

  Fly   898 TAVHLAAQNGHGQVLDVLKSTNSLRINSKKLGLTPLHVAAYYGQADTVRELLTSVPATVKSETPT 962
            |.|.:..:|   ||                   |||||||:|.. |.|..||....|:.|:
Worm   581 TPVDIEGKN---QV-------------------TPLHVAAHYNN-DKVAMLLLENGASAKA---- 618

  Fly   963 GQSLFGDLGTESGMTPLHLAAFSGNENVVRLLLNSAGVQVDA-ATIENGYNPLHLACFGGHMSVV 1026
                    ..::|.||||:||......:...||.   .:.|. |....|:.||||:...||..:.
Worm   619 --------AAKNGYTPLHIAAKKNQMEIASTLLQ---FKADPNAKSRAGFTPLHLSAQEGHKEIS 672

  Fly  1027 GLLLSRSAELLQSQDRNGRTGLHIAAMHGHIQMVEILLGQGAEINATDRNGWTPLHCAAKAGHLE 1091
            |||:...:: :.::..||.|.:|:.|...|:.:.:||...|||||:....|:||||.|...|.|.
Worm   673 GLLIENGSD-VGAKANNGLTAMHLCAQEDHVPVAQILYNNGAEINSKTNAGYTPLHVACHFGQLN 736

  Fly  1092 VVKLLCEAGASPKSETNYGCAAIWFAASEGHNEVLRYLMN-----KEHDTYG---LMEDKRFVYN 1148
            :||.|.|.||....:|......:..||.:|||..:|||:.     .|....|   |...:|..|
Worm   737 MVKFLVENGADVGEKTRASYTPLHQAAQQGHNNCVRYLLENGASPNEQTATGQTPLSIAQRLGY- 800

  Fly  1149 LMVVSKNHNNKPIQE-FVLVSPAPVDTAAKLSNIYIVLSTKEKERAKDLVAAGKQCEAMATELLA 1212
               ||.....:.:.| .|:.....||...|..|         .|...:.:.:..:.|..|.|..|
Worm   801 ---VSVVETLRTVTETTVITETTTVDERYKPQN---------PEAMNETMFSESEDEGQAAEHEA 853

  Fly  1213 LAAGSDSAGKILQATDKRNVEFLDVLIENEQKEVIAHTV------VQRYLQELWHG 1262
            :||              ...:|.|.|.:..|.....|.:      :|| .|||.:|
Worm   854 VAA--------------HEKDFSDNLTQGLQDSTGVHMIHTGEQLLQR-SQELENG 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nompC	NP_523483.2	ANK repeat	129..157	CDD:293786
		Ank_2	131..228	CDD:289560	9/40 (23%)
		ANK	155..319	CDD:238125	43/131 (33%)
		ANK repeat	159..186	CDD:293786
		ANK repeat	232..265	CDD:293786	11/32 (34%)
		Ank_2	237..331	CDD:289560	36/93 (39%)
		ANK	263..387	CDD:238125	41/126 (33%)
		ANK repeat	267..298	CDD:293786	13/30 (43%)
		ANK repeat	300..331	CDD:293786	11/30 (37%)
		Ank_2	305..398	CDD:289560	23/95 (24%)
		ANK	329..454	CDD:238125	32/127 (25%)
		ANK repeat	367..398	CDD:293786	7/33 (21%)
		ANK repeat	400..431	CDD:293786	12/30 (40%)
		Ank_2	405..498	CDD:289560	20/92 (22%)
		ANK	428..555	CDD:238125	33/127 (26%)
		ANK repeat	433..463	CDD:293786	8/29 (28%)
		ANK repeat	469..499	CDD:293786	0/29 (0%)
		ANK	496..641	CDD:238125	29/145 (20%)
		ANK repeat	501..532	CDD:293786	13/31 (42%)
		Ank_2	507..616	CDD:289560	20/109 (18%)
		ANK repeat	534..575	CDD:293786	10/40 (25%)
		ANK repeat	577..616	CDD:293786	0/38 (0%)
		Ank_2	625..722	CDD:289560	23/96 (24%)
		ANK	654..780	CDD:238125	41/125 (33%)
		ANK repeat	660..690	CDD:293786	10/29 (34%)
		ANK repeat	692..723	CDD:293786	9/30 (30%)
		Ank_2	697..790	CDD:289560	35/92 (38%)
		ANK	720..847	CDD:238125	44/126 (35%)
		ANK repeat	725..757	CDD:293786	11/31 (35%)
		ANK repeat	759..790	CDD:293786	15/30 (50%)
		Ank_5	779..834	CDD:290568	17/54 (31%)
		ANK	787..915	CDD:238125	35/127 (28%)
		ANK repeat	792..824	CDD:293786	9/31 (29%)
		ANK repeat	861..893	CDD:293786	10/31 (32%)
		Ank_4	865..915	CDD:290365	15/49 (31%)
		Ank_4	929..995	CDD:290365	21/65 (32%)
		ANK repeat	932..972	CDD:293786	13/39 (33%)
		ANK	969..1096	CDD:238125	44/127 (35%)
		ANK repeat	974..1007	CDD:293786	11/33 (33%)
		Ank_2	979..1074	CDD:289560	31/95 (33%)
		ANK repeat	1009..1041	CDD:293786	10/31 (32%)
		ANK	1039..1159	CDD:238125	43/127 (34%)
		ANK repeat	1043..1074	CDD:293786	13/30 (43%)
		Ank_2	1048..1135	CDD:289560	34/91 (37%)
		ANK repeat	1076..1101	CDD:293786	12/24 (50%)
		ANK repeat	1109..1134	CDD:293786	8/29 (28%)
		Ion_trans	<1393..1598	CDD:278921
unc-44	NP_001367345.1	ANK repeat	32..63	CDD:293786	7/33 (21%)
		PHA03095	37..>387	CDD:222980	120/490 (24%)
		ANK repeat	65..96	CDD:293786	11/32 (34%)
		ANK repeat	98..129	CDD:293786	13/30 (43%)
		ANK repeat	131..156	CDD:293786	10/24 (42%)
		ANK repeat	197..224	CDD:293786	6/26 (23%)
		ANK repeat	226..257	CDD:293786	12/30 (40%)
		PHA02876	<242..>648	CDD:165207	145/587 (25%)
		ANK repeat	259..290	CDD:293786	9/65 (14%)
		ANK repeat	292..322	CDD:293786	13/30 (43%)
		ANK repeat	325..356	CDD:293786	13/102 (13%)
		ANK repeat	358..389	CDD:293786	10/50 (20%)
		ANK repeat	391..422	CDD:293786	9/30 (30%)
		ANK repeat	424..455	CDD:293786	11/31 (35%)
		ANK repeat	457..488	CDD:293786	15/30 (50%)
		ANK repeat	490..519	CDD:293786	7/29 (24%)
		ANK repeat	523..552	CDD:293786	8/28 (29%)
		Ank_2	555..>780	CDD:423045	86/277 (31%)
		ANK repeat	556..586	CDD:293786	12/43 (28%)
		ANK repeat	589..620	CDD:293786	17/65 (26%)
		ANK repeat	622..652	CDD:293786	10/32 (31%)
		ANK repeat	655..685	CDD:293786	10/30 (33%)
		ANK repeat	688..719	CDD:293786	13/30 (43%)
		ANK repeat	721..752	CDD:293786	14/30 (47%)
		ANK repeat	754..784	CDD:293786	8/29 (28%)
		Ank_4	756..807	CDD:372654	15/54 (28%)
		ZU5	1008..1110	CDD:128514
		UPA_2	1337..1472	CDD:375346
		Death_ank	1503..1580	CDD:260029
		PTZ00449	<1770..2112	CDD:185628
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910