DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nompC and Ank3

DIOPT Version :9

Sequence 1:	NP_523483.2	Gene:	nompC / 33768	FlyBaseID:	FBgn0016920	Length:	1761	Species:	Drosophila melanogaster
Sequence 2:	XP_036011414.1	Gene:	Ank3 / 11735	MGIID:	88026	Length:	4691	Species:	Mus musculus

Alignment Length:	1170	Identity:	312/1170 - (26%)
Similarity:	496/1170 - (42%)	Gaps:	265/1170 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   255 AQTAEQLKAT-----TANGDTALHLAARRRDVDMVRILVDYGTNVDTQNGEGQTPLHIAAAEGDE 314
            |..|.|||..     .|..:|......|:|..|..:           ::....:.|..|.|...|
Mouse     2 AHAASQLKKNRDLEINAEEETEKKRKHRKRSRDRKK-----------KSDANASYLRAARAGHLE 55

  Fly   315 ALLKYF-YGVRASASIADNQDRTPMHLAAENGHAHVIEILADKFKASIFERTKDGSTLMHIASLN 378
            ..|.|. .||  ..:|.:......:|||::.||..|:..|..: :|::...||.|:|.:|||||.
Mouse    56 KALDYIKNGV--DVNICNQNGLNALHLASKEGHVEVVSELLQR-EANVDAATKKGNTALHIASLA 117

  Fly   379 GHAECATMLFKKGVYLHMPNKDGARSIHTAAAYGHTGIINTLLQKGEKVDVTTNDNYTALHIAVE 443
            |.||...:|...|..::..:::|...::.||...|..::..||..|....:.|.|.:|.|.:|::
Mouse   118 GQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVRFLLDNGASQSLATEDGFTPLAVALQ 182

  Fly   444 SAKPAVVETLLGFGADVHVRGGKLRETPLHIAARVKDGDRCALMLLKSGASP--------NLTTD 500
            .....||..||     .:...||:|...|||||| ||..:.|.:||::..:.        |..|:
Mouse   183 QGHDQVVSLLL-----ENDTKGKVRLPALHIAAR-KDDTKAAALLLQNDTNADVESKMVVNRATE 241

  Fly   501 DCLTPVHVAARHGNLATLMQLLEDEGDPLYKSNTGETPLHMACRACHPDIVRHLIETVKEKHGPD 565
            ...||:|:||.:||:.....||.......:.:....||||:|.:..:.::|:.|::...:
Mouse   242 SGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAK----- 301

  Fly   566 KATTYINSVNEDGATALHYTCQITKEEVKIPESDKQIVRMLLENGADVTLQTKTALETAFHYCAV 630
                 |::...||.|.||...:         ...:|:|.|||:..|.:..:||.
Mouse   302 -----IDAKTRDGLTPLHCGAR---------SGHEQVVEMLLDRSAPILSKTKN----------- 341

  Fly   631 AGNNDVLMEMISHMNPTDIQKAMNRQSSVGWTPLLIACHRGHMELVNNLLANHARVDVFDTEGRS 695
                                         |.:||.:|....|:..|..||.::..||....:..:
Mouse   342 -----------------------------GLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLT 377

  Fly   696 ALHLAAERGYLHVCDALLTNKAFINSKSRVGRTALHLAAMNGFTHLVKFLIKDHNAVIDILTLRK 760
            |||:||..|:..|...||..||..|:|           |:|||
Mouse   378 ALHVAAHCGHYKVAKVLLDKKASPNAK-----------ALNGF---------------------- 409

  Fly   761 QTPLHLAAASGQMEVCQLLLELGANIDATDDLGQKPIHVAAQNNYSEVAKLFLQQHPSLVNATSK 825
             ||||:|....::.|.:|||:.||:|.|..:.|..||||||...:..:... |..|.:..|.|:.
Mouse   410 -TPLHIACKKNRIRVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQ-LMHHGASPNTTNV 472

  Fly   826 DGNTCAHIAAMQGSVKVIEELMKFDRSGVISARNKLTDATPLQLAAEGGHADVVKALVRAGASCT 890
            .|.|..|:||..|..:|:..|::  ....:.|:.| .|.|||.::|..|.||:|:.|::.|||..
Mouse   473 RGETALHMAARSGQAEVVRYLVQ--DGAQVEAKAK-DDQTPLHISARLGKADIVQQLLQQGASPN 534

  Fly   891 EENKAGFTAVHLAAQNGHGQVLD-VLKSTNSLRINSKKLGLTPLHVAAYYGQADTVRELLTSVPA 954
            ....:|:|.:||||:.||..|.. :|....||.|.:|| |.|||||||.||:.:....||.
Mouse   535 AATTSGYTPLHLAAREGHEDVAAFLLDHGASLSITTKK-GFTPLHVAAKYGKLEVASLLLQ---- 594

  Fly   955 TVKSETPTGQSLFGDLGTESGMTPLHLAAFSGNENVVRLLLNSAGVQVDAATIENGYNPLHLAC- 1018
              ||.:|       |...:||:||||:||...|:.|..|||:. |....||. :|||.|||:|.
Mouse   595 --KSASP-------DAAGKSGLTPLHVAAHYDNQKVALLLLDQ-GASPHAAA-KNGYTPLHIAAK 648

  Fly  1019 ------------FG--------------------GHMSVVGLLLSRSAELLQSQDRNGRTGLHIA 1051
                        :|                    ||:.:|.|||||:|.:..| :::|.|.||:|
Mouse   649 KNQMDIATSLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLSRNANVNLS-NKSGLTPLHLA 712

  Fly  1052 AMHGHIQMVEILLGQGAEINATDRNGWTPLHCAAKAGHLEVVKLLCEAGASPKSETNYGCAAIWF 1116
            |....:.:.|:|:.|||.::|..:.|:||||.....|::::|..|.:..|...::|..|..|:..
Mouse   713 AQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTALHQ 777

  Fly  1117 AASEGHNEVLRYLMNKE--------HDTYGLMEDKRFVY-----NLMVVS-----------KNHN 1157
            ||.:||..::..|:...        :....|...:|..|     .|.||:           |:..
Mouse   778 AAQQGHTHIINVLLQNNASPNELTVNGNTALAIARRLGYISVVDTLKVVTEEIMTTTTITEKHKM 842

  Fly  1158 NKP--IQEFVLVSPAPVDTAA---KLSNIYIVLSTKEKERA------------------------ 1193
            |.|  :.|.:.:|...|..|:   |||:...:...:|.::.
Mouse   843 NVPETMNEVLDMSDDEVRKASAPEKLSDGEYISDGEEGDKCTWFKIPKVQEVLVKSEDAITGDTD 907

  Fly  1194 -----KDLVAAGKQCEAMATE-LLALAAGSDSAGKILQ------------ATDKRNVEFLDVLIE 1240
                 :||...|.  :::..| .:..:.|:.||...:.            |.|...:|  ::|:.
Mouse   908 KYLGPQDLKELGD--DSLPAEGYVGFSLGARSASPKISSDRSYTLNRSSYARDSMMIE--ELLVP 968

  Fly  1241 NEQKEVIAHTVVQRYLQELWHGSLTWASWKILLLLVAFIVCPPVWIGFTFPMGHKFNKVPIIKFM 1305
            ::::.:       .:.:|....||...||....|....:|..||..|.:.|: .:::...::.||
Mouse   969 SKEQHL-------TFTREFDSDSLRHYSWAADTLDNVNLVSSPVHSGCSSPL-PQYDSRFLVSFM 1025

Fly 1306 1305
Mouse 1026 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nompC	NP_523483.2	ANK repeat	129..157	CDD:293786
		Ank_2	131..228	CDD:289560
		ANK	155..319	CDD:238125	15/68 (22%)
		ANK repeat	159..186	CDD:293786
		ANK repeat	232..265	CDD:293786	5/14 (36%)
		Ank_2	237..331	CDD:289560	19/81 (23%)
		ANK	263..387	CDD:238125	34/129 (26%)
		ANK repeat	267..298	CDD:293786	4/30 (13%)
		ANK repeat	300..331	CDD:293786	9/31 (29%)
		Ank_2	305..398	CDD:289560	31/93 (33%)
		ANK	329..454	CDD:238125	37/124 (30%)
		ANK repeat	367..398	CDD:293786	12/30 (40%)
		ANK repeat	400..431	CDD:293786	7/30 (23%)
		Ank_2	405..498	CDD:289560	30/100 (30%)
		ANK	428..555	CDD:238125	40/134 (30%)
		ANK repeat	433..463	CDD:293786	8/29 (28%)
		ANK repeat	469..499	CDD:293786	12/37 (32%)
		ANK	496..641	CDD:238125	32/144 (22%)
		ANK repeat	501..532	CDD:293786	9/30 (30%)
		Ank_2	507..616	CDD:289560	26/108 (24%)
		ANK repeat	534..575	CDD:293786	8/40 (20%)
		ANK repeat	577..616	CDD:293786	11/38 (29%)
		Ank_2	625..722	CDD:289560	22/96 (23%)
		ANK	654..780	CDD:238125	34/125 (27%)
		ANK repeat	660..690	CDD:293786	10/29 (34%)
		ANK repeat	692..723	CDD:293786	12/30 (40%)
		Ank_2	697..790	CDD:289560	29/92 (32%)
		ANK	720..847	CDD:238125	37/126 (29%)
		ANK repeat	725..757	CDD:293786	4/31 (13%)
		ANK repeat	759..790	CDD:293786	13/30 (43%)
		Ank_5	779..834	CDD:290568	20/54 (37%)
		ANK	787..915	CDD:238125	44/128 (34%)
		ANK repeat	792..824	CDD:293786	10/31 (32%)
		ANK repeat	861..893	CDD:293786	13/31 (42%)
		Ank_4	865..915	CDD:290365	21/50 (42%)
		Ank_4	929..995	CDD:290365	27/65 (42%)
		ANK repeat	932..972	CDD:293786	14/39 (36%)
		ANK	969..1096	CDD:238125	54/159 (34%)
		ANK repeat	974..1007	CDD:293786	16/32 (50%)
		Ank_2	979..1074	CDD:289560	42/127 (33%)
		ANK repeat	1009..1041	CDD:293786	18/64 (28%)
		ANK	1039..1159	CDD:238125	37/143 (26%)
		ANK repeat	1043..1074	CDD:293786	12/30 (40%)
		Ank_2	1048..1135	CDD:289560	27/94 (29%)
		ANK repeat	1076..1101	CDD:293786	8/24 (33%)
		ANK repeat	1109..1134	CDD:293786	7/32 (22%)
		Ion_trans	<1393..1598	CDD:278921
Ank3	XP_036011414.1	Ank_2	59..>304	CDD:423045	75/263 (29%)
		ANK repeat	73..104	CDD:293786	8/31 (26%)
		ANK repeat	106..137	CDD:293786	12/30 (40%)
		ANK repeat	139..164	CDD:293786	6/24 (25%)
		Ank_2	195..>437	CDD:423045	85/335 (25%)
		ANK repeat	205..240	CDD:293786	12/35 (34%)
		ANK repeat	242..273	CDD:293786	9/30 (30%)
		ANK repeat	275..306	CDD:293786	8/40 (20%)
		ANK repeat	308..333	CDD:293786	10/33 (30%)
		ANK repeat	341..372	CDD:293786	10/70 (14%)
		PHA03095	377..>665	CDD:222980	119/341 (35%)
		ANK repeat	377..405	CDD:293786	13/38 (34%)
		ANK repeat	407..438	CDD:293786	16/53 (30%)
		ANK repeat	440..471	CDD:293786	10/31 (32%)
		ANK repeat	473..504	CDD:293786	9/32 (28%)
		ANK repeat	506..537	CDD:293786	13/30 (43%)
		ANK repeat	539..568	CDD:293786	12/28 (43%)
		Ank_2	559..>796	CDD:423045	85/253 (34%)
		ANK repeat	572..601	CDD:293786	16/42 (38%)
		ANK repeat	605..634	CDD:293786	14/29 (48%)
		ANK repeat	638..669	CDD:293786	8/30 (27%)
		ANK repeat	671..702	CDD:293786	10/31 (32%)
		ANK repeat	704..735	CDD:293786	12/30 (40%)
		ANK repeat	737..768	CDD:293786	9/30 (30%)
		ANK repeat	770..798	CDD:293786	7/27 (26%)
		Ank_4	771..823	CDD:372654	10/51 (20%)
		ZU5	1018..1155	CDD:128514	2/8 (25%)
		UPA_2	1377..1506	CDD:375346
		Herpes_BLLF1	<1542..1949	CDD:282904
		DUF2890	3296..>3412	CDD:314108
		Death_ank3	4113..4196	CDD:176781
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810