DRSC/TRiP Functional Genomics Resources

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Protein Alignment nompC and FPGT-TNNI3K

DIOPT Version :9

Sequence 1:NP_523483.2 Gene:nompC / 33768 FlyBaseID:FBgn0016920 Length:1761 Species:Drosophila melanogaster
Sequence 2:NP_001106279.3 Gene:FPGT-TNNI3K / 100526835 HGNCID:42952 Length:936 Species:Homo sapiens


Alignment Length:979 Identity:195/979 - (19%)
Similarity:333/979 - (34%) Gaps:401/979 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   466 KLRETPL----HI-----AARVKDGDR--CALMLLKSGASPNLTTDDCLTPVHVAARHGNLATLM 519
            |.:|.||    |:     .|::.:|..  |||              .||..::  ....|..|::
Human    62 KRKELPLGVQYHVFVDPAGAKIGNGGSTLCAL--------------QCLEKLY--GDKWNSFTIL 110

  Fly   520 QLLEDEGDPLYKSNTGETPLHMACRACHPDIVRHLIETVKEKH--------GPDKATTYINSVNE 576
            .:..||    :|....|:.: :.......|:      .:|||.        |.|:|.:.:|    
Human   111 LIHSDE----WKKKVSESYV-ITIERLEDDL------QIKEKELTELRNIFGSDEAFSKVN---- 160

  Fly   577 DGATALHYTCQITKEEVKIPESDKQIVRMLLENGADVTLQTKTALETAFHYCAVAG--NNDVLME 639
                 |:|.                     .|||..:           .|.|.:.|  .:.:...
Human   161 -----LNYR---------------------TENGLSL-----------LHLCCICGGKKSHIRTL 188

  Fly   640 MISHMNPTDIQKAMNRQSSVGWTPLLIACHRGHMELVNNLLANHARVDVFDTEGRSALHLAAERG 704
            |:..:.|       :|.:..|:|.|.:|.::.:.||:.:||.:.|.:......|.:|||:|...|
Human   189 MLKGLRP-------SRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAG 246

  Fly   705 YLHVCDALLTNKAFINSKSRVGRTALHLAAMNGFTHLVKFLIKDHNAVIDILTLRKQTPLHLAAA 769
            :|...|.||.:.|.:|.:..|                  |.                ||||:||.
Human   247 HLEAADVLLQHGANVNIQDAV------------------FF----------------TPLHIAAY 277

  Fly   770 SGQMEVCQLLLELGANIDATDDLGQKPIHVAAQNNYSEVAKLFLQQHPSLVNATSKDGNTCAHIA 834
            .|..:|.:|||:.||:::.:.::|.:|:|:|:...:..:|||.::                    
Human   278 YGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLME-------------------- 322

  Fly   835 AMQGSVKVIEELMKFDRSGVISARNKLTDATPLQLAAEGGHADVVKALVRAGASCTEENKAGFTA 899
                                                 ||..|||                     
Human   323 -------------------------------------EGSKADV--------------------- 329

  Fly   900 VHLAAQNGHGQVLDVLKSTNSLRINSKKLGLTPLHVAAYYGQADTVRELLTS----VPATVKSET 960
               .||:....|                    |||..:.:|..|.|:.||.|    .|..|    
Human   330 ---NAQDNEDHV--------------------PLHFCSRFGHHDIVKYLLQSDLEVQPHVV---- 367

  Fly   961 PTGQSLFGDLGTESGMTPLHLAAFSGNENVVRLLLNSAGVQVDAATIENGYN--PLHLAC-FGGH 1022
                :::||       ||||||.::|...|.:.::..:|  .::.|.||.::  ..|.|| :|..
Human   368 ----NIYGD-------TPLHLACYNGKFEVAKEIIQISG--TESLTKENIFSETAFHSACTYGKS 419

  Fly  1023 MSVVGLLLSRSAELLQSQDRNGRTGLHIAAMHGHIQMVEILLGQGAEIN---------ATDRNGW 1078
            :.:|..||.::...:..|.|:|.||||.|..||||::|:.||..||::|         :.:::..
Human   420 IDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQ 484

  Fly  1079 TPLHCAAKAGHLEVVKLL-----------CEAGASPKSETNY----------------------- 1109
            |.|..|.:.||..:|.||           |...:.|..:.:|                       
Human   485 TCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQPGGDGSYVSVPSPLGKIKSMTKEKADILLL 549

  Fly  1110 --GCAA---IWFAASEGH-----------------NEVL---RYLMNKEHDTYGLMED-KRFVYN 1148
              |..:   :..:..|.|                 |:::   ||..|    ||....| ..|...
Human   550 RAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRAN----TYCSKSDVDMFCRE 610

  Fly  1149 LMVVSK-NHN----------NKPIQEFVLVSPAPVDTAAKLSNIYIVLSTKEKERAKDLVAAGKQ 1202
            :.::.: ||.          |.|.| |.:|:.. :...:..|.::      |::|..||      
Human   611 VSILCQLNHPCVIQFVGACLNDPSQ-FAIVTQY-ISGGSLFSLLH------EQKRILDL------ 661

  Fly  1203 CEAMATELLALAAGSDSAGKILQATDKRNVEFLDVLIENEQKEVIAHTVVQRYLQEL-------W 1260
             ::.....:.:|.|.:....:.|....|::...::|:..:...|:|.....|:||.|       .
Human   662 -QSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQ 725

  Fly  1261 HGSLTWAS-----------------------WKILLLLVAFI---------------VCPPVWIG 1287
            .|:|.|.:                       |:||...:.|.               :.||  ||
Human   726 PGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPP--IG 788

  Fly  1288 FTFP 1291
            ::.|
Human   789 YSIP 792

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nompCNP_523483.2 ANK repeat 129..157 CDD:293786
Ank_2 131..228 CDD:289560
ANK 155..319 CDD:238125
ANK repeat 159..186 CDD:293786
ANK repeat 232..265 CDD:293786
Ank_2 237..331 CDD:289560
ANK 263..387 CDD:238125
ANK repeat 267..298 CDD:293786
ANK repeat 300..331 CDD:293786
Ank_2 305..398 CDD:289560
ANK 329..454 CDD:238125
ANK repeat 367..398 CDD:293786
ANK repeat 400..431 CDD:293786
Ank_2 405..498 CDD:289560 10/42 (24%)
ANK 428..555 CDD:238125 19/99 (19%)
ANK repeat 433..463 CDD:293786
ANK repeat 469..499 CDD:293786 9/40 (23%)
ANK 496..641 CDD:238125 24/154 (16%)
ANK repeat 501..532 CDD:293786 6/30 (20%)
Ank_2 507..616 CDD:289560 19/116 (16%)
ANK repeat 534..575 CDD:293786 9/48 (19%)
ANK repeat 577..616 CDD:293786 5/38 (13%)
Ank_2 625..722 CDD:289560 27/98 (28%)
ANK 654..780 CDD:238125 33/125 (26%)
ANK repeat 660..690 CDD:293786 9/29 (31%)
ANK repeat 692..723 CDD:293786 12/30 (40%)
Ank_2 697..790 CDD:289560 25/92 (27%)
ANK 720..847 CDD:238125 23/126 (18%)
ANK repeat 725..757 CDD:293786 2/31 (6%)
ANK repeat 759..790 CDD:293786 13/30 (43%)
Ank_5 779..834 CDD:290568 11/54 (20%)
ANK 787..915 CDD:238125 15/127 (12%)
ANK repeat 792..824 CDD:293786 7/31 (23%)
ANK repeat 861..893 CDD:293786 5/31 (16%)
Ank_4 865..915 CDD:290365 8/49 (16%)
Ank_4 929..995 CDD:290365 21/69 (30%)
ANK repeat 932..972 CDD:293786 13/43 (30%)
ANK 969..1096 CDD:238125 44/138 (32%)
ANK repeat 974..1007 CDD:293786 9/32 (28%)
Ank_2 979..1074 CDD:289560 35/106 (33%)
ANK repeat 1009..1041 CDD:293786 8/34 (24%)
ANK 1039..1159 CDD:238125 42/199 (21%)
ANK repeat 1043..1074 CDD:293786 16/39 (41%)
Ank_2 1048..1135 CDD:289560 31/154 (20%)
ANK repeat 1076..1101 CDD:293786 9/35 (26%)
ANK repeat 1109..1134 CDD:293786 8/72 (11%)
Ion_trans <1393..1598 CDD:278921
FPGT-TNNI3KNP_001106279.3 ANK repeat 167..199 CDD:293786 8/49 (16%)
Ank_2 172..265 CDD:403870 27/99 (27%)
ANK repeat 201..232 CDD:293786 9/30 (30%)
PHA03095 221..>515 CDD:222980 103/445 (23%)
ANK repeat 235..265 CDD:293786 12/29 (41%)
ANK repeat 267..298 CDD:293786 15/64 (23%)
ANK repeat 300..333 CDD:293786 13/113 (12%)
ANK repeat 335..363 CDD:293786 10/47 (21%)
ANK repeat 370..403 CDD:293786 12/41 (29%)
ANK repeat 405..438 CDD:293786 7/32 (22%)
ANK repeat 440..470 CDD:293786 16/29 (55%)
PKc_TNNI3K 570..823 CDD:270966 43/244 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D53364at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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