DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nompC and tnks

DIOPT Version :9

Sequence 1:	NP_523483.2	Gene:	nompC / 33768	FlyBaseID:	FBgn0016920	Length:	1761	Species:	Drosophila melanogaster
Sequence 2:	XP_004911090.1	Gene:	tnks / 100497226	XenbaseID:	XB-GENE-5828012	Length:	1306	Species:	Xenopus tropicalis

Alignment Length:	1316	Identity:	296/1316 - (22%)
Similarity:	457/1316 - (34%)	Gaps:	438/1316 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SQPRGGRGGGRGGGVGRKTPSSLTGPPDESA---TPSERATPASKADSDPKDDSSSNGDKKDMDL 63
            |||.|......|     .||..|:.||.|:|   :|...:.|
Frog    69 SQPEGEAASQPG-----ITPRPLSPPPGEAANILSPISSSLP----------------------- 105

  Fly    64 FPAPKPPSAGASIRDTANKVLGLAMKSEWTPIEAELKKLEKYVANVGEDGNHI----PLAGVHDM 124
             |||.|.|..:|...:::.    ::.|..:|.|:....:   :..||..|  |    ||:.|
Frog   106 -PAPAPSSGSSSSSSSSSN----SLSSGGSPAESPESGV---IGGVGSGG--IGPGGPLSAV--- 157

  Fly   125 NTGMTPLMYATKDNKTAIMDRMIELG----ADVGARNNDNYNVLHIAAMYSREDVVKLLLTKRGV 185
            :.....|..|.::...:.:.|::|.|    .|:..|.:   ..||.||.:.|:|||:.||
Frog   158 SGAFRELFEACRNGDVSRVRRLLEPGNVNAKDMAGRKS---TPLHFAAGFGRKDVVEHLL----- 214

  Fly   186 DPFSTGGSRSQTAVHLVSSRQTGTATNILRALLAAAGKDIRLKADGRGKIPLLLAVESGNQSMCR 250
                                |||.              ::..:.|| |.|||..|...|:..:.
Frog   215 --------------------QTGA--------------NVHARDDG-GLIPLHNACSFGHAEVV- 243

  Fly   251 ELLAAQTAEQLKATTANGDTALHLAARRRDVDMVRILVDYGTNVDTQNGEGQTPLHI-------- 307
            .||..|.|:.......| .|.||.|:.:..:|:..:|:.:|.:...:|.:|::.|.:
Frog   244 TLLLCQGADPNARDNWN-YTPLHEASIKGKIDVCIVLLQHGADPSIRNTDGKSALDLADPSAKAV 307

  Fly   308 ------------AAAEG-DEALLKYFYGVRASASIADNQDRTPMHLAAENGHAHVIEILADKFKA 359
                        ||..| :|.|:.....:..:...:|.:..||:||||......::::|
Frog   308 LTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLL------ 366

  Fly   360 SIFERTKDGSTLMHIASLNGHAECATMLFKKGVYLHMPNKDGARSIHTAAAYGHTGIINTLLQKG 424
                       |.|                 |..:|..:|.|...:|.|.:|||..:...||:.|
Frog   367 -----------LQH-----------------GADVHAKDKGGLVPLHNACSYGHFEVTELLLKHG 403

  Fly   425 EKVDVTTNDNYTALHIAVESAKPAVVETLLGFGADVHVRGGKLRETPLHIAARVKDG-DRCALML 488
            ..|:......:|.||.|....:..|...||..|||           |..:....|.. |......
Frog   404 ACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGAD-----------PTLVNCHGKSAVDMAPTPE 457

  Fly   489 LKSGASPNLTTDDCLTPVHVAARHGNLATLMQLLEDEGDPLYKSNTGETPLHMACRACHPDIVRH 553
            ||...|........|.    |||..::|.:.:.|..|.....:..:.||.||.|..:.||
Frog   458 LKERLSYEFKGHSLLQ----AAREADMAKVKKTLALEIINFKQPQSHETALHCAVASLHP----- 513

  Fly   554 LIETVKEKHGPDKATTYINSVNEDGATALHYTCQITKEEVKIPESDKQIVRMLLENGADVTLQTK 618
                                                        ..|||..:||..||.|..:.|
Frog   514 --------------------------------------------KRKQITELLLRKGASVNEKNK 534

  Fly   619 TALETAFHYCAVAGNNDVLMEMISHMNPTDIQKAMNRQSSVGWTPLLIACHRGHMELVNNLLANH 683
            ..:                                        |||.:|..|.|.::|..|..:.
Frog   535 DFM----------------------------------------TPLHVAAERAHNDVVEVLHKHG 559

  Fly   684 ARVDVFDTEGRSALHLAAERGYLHVCDALLT-------------------NKA---FINSKSRVG 726
            |:::..||.|::|||.||..|:|..|..||:                   |:|   .:|.:|...
Frog   560 AKMNALDTLGQTALHRAALGGHLQTCRLLLSFGSDASIVSLQGFTAAQMGNEAVQQILNVESTPV 624

  Fly   727 RTA-----LHLAAMNGFTHLVKFLIKDHNAVIDILTLRKQTPLHLAAASGQMEVCQLLLELGANI 786
            ||:     |..|:..|....||.|....|.....|..|..||||.||...::.|.:.||..||::
Frog   625 RTSDVDYRLLEASKAGDLDTVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADV 689

  Fly   787 DATDDLGQKPIHVAAQNNYSEVAKLFLQQHPSLVNATSKDGNTCAHIAAMQGSVKVIEELMKFDR 851
            .|.|..|..|:|.|....:.|||:| |.:|.:.||                     :.:|.||
Frog   690 HAKDKGGLVPLHNACSYGHYEVAEL-LVRHGASVN---------------------VADLWKF-- 730

  Fly   852 SGVISARNKLTDATPLQLAAEGGHADVVKALVRAGASCTEENKAGFTAVHLAAQNGHGQVLDVLK 916
                         |||..||..|..::.|.|::.||..|::|:.|.|.:.| .::|...:.|:|:
Frog   731 -------------TPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDL-VKDGDTDIQDLLR 781

  Fly   917 STNSLRINSKKLGLTPLHVAAYYGQADTVRELLTSVPATVKSETPTGQSLFGDLGTESGMTPLHL 981
            ...:|...:||            |....|::|.|.  ..:......|::          .|||||
Frog   782 GDAALLDAAKK------------GCLARVQKLCTQ--ENINCRDTQGRN----------STPLHL 822

  Fly   982 AAFSGNENVVRLLLNSAGVQVDAATIENGYNPLHLACFGGHMSVVGLLLSRSAELLQSQDRNGRT 1046
            ||                          |||.|.:|.:         ||...|: :.:||:.|..
Frog   823 AA--------------------------GYNNLEVAEY---------LLEHGAD-VNAQDKGGLI 851

  Fly  1047 GLHIAAMHGHIQMVEILLGQGAEINATDRNGWTPLHCAAKAGHLEVVKLLCEAGASPKSETNYGC 1111
            .||.||.:||:.:..:|:.....:||||:..:||||.||:.|..::..||...||.|..:.....
Frog   852 PLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQESQ 916

  Fly  1112 AAIWFAASEGHNEVLRYLMNKEHDTYGLMEDKR--------FVYNLMVVSKNHNNKPIQEFVLVS 1168
            ..:..|.::              |...|:.|..        |.....|||.:          ::|
Frog   917 TPLDLATAD--------------DIRALLIDAMPPEALPTCFKPQATVVSAS----------IIS 957

  Fly  1169 PAPVDTAAKLSNIYIVLSTKEKERAKDLVAAGKQCEAMATELLALAAGS-DSAGKILQATDKRNV 1232
            ||...:.                     ::|....:.:...|..||.|. .:||.....|:::..
Frog   958 PASTPSC---------------------LSAASSIDNLTGPLAELAVGGVSNAGDGAAGTERKEG 1001

  Fly  1233 EF--LDVLIENEQKEV 1246
            |.  ||:.|....|.:
Frog  1002 EVTGLDMNINQFLKSL 1017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nompC	NP_523483.2	ANK repeat	129..157	CDD:293786	6/31 (19%)
		Ank_2	131..228	CDD:289560	20/100 (20%)
		ANK	155..319	CDD:238125	42/184 (23%)
		ANK repeat	159..186	CDD:293786	10/26 (38%)
		ANK repeat	232..265	CDD:293786	10/32 (31%)
		Ank_2	237..331	CDD:289560	23/114 (20%)
		ANK	263..387	CDD:238125	26/144 (18%)
		ANK repeat	267..298	CDD:293786	8/30 (27%)
		ANK repeat	300..331	CDD:293786	7/51 (14%)
		Ank_2	305..398	CDD:289560	18/113 (16%)
		ANK	329..454	CDD:238125	28/124 (23%)
		ANK repeat	367..398	CDD:293786	4/30 (13%)
		ANK repeat	400..431	CDD:293786	10/30 (33%)
		Ank_2	405..498	CDD:289560	25/93 (27%)
		ANK	428..555	CDD:238125	30/127 (24%)
		ANK repeat	433..463	CDD:293786	10/29 (34%)
		ANK repeat	469..499	CDD:293786	6/30 (20%)
		ANK	496..641	CDD:238125	23/144 (16%)
		ANK repeat	501..532	CDD:293786	7/30 (23%)
		Ank_2	507..616	CDD:289560	21/108 (19%)
		ANK repeat	534..575	CDD:293786	7/40 (18%)
		ANK repeat	577..616	CDD:293786	8/38 (21%)
		Ank_2	625..722	CDD:289560	25/118 (21%)
		ANK	654..780	CDD:238125	44/152 (29%)
		ANK repeat	660..690	CDD:293786	9/29 (31%)
		ANK repeat	692..723	CDD:293786	14/52 (27%)
		Ank_2	697..790	CDD:289560	36/119 (30%)
		ANK	720..847	CDD:238125	38/131 (29%)
		ANK repeat	725..757	CDD:293786	9/36 (25%)
		ANK repeat	759..790	CDD:293786	13/30 (43%)
		Ank_5	779..834	CDD:290568	18/54 (33%)
		ANK	787..915	CDD:238125	34/127 (27%)
		ANK repeat	792..824	CDD:293786	12/31 (39%)
		ANK repeat	861..893	CDD:293786	11/31 (35%)
		Ank_4	865..915	CDD:290365	17/49 (35%)
		Ank_4	929..995	CDD:290365	12/65 (18%)
		ANK repeat	932..972	CDD:293786	5/39 (13%)
		ANK	969..1096	CDD:238125	36/126 (29%)
		ANK repeat	974..1007	CDD:293786	7/32 (22%)
		Ank_2	979..1074	CDD:289560	25/94 (27%)
		ANK repeat	1009..1041	CDD:293786	8/31 (26%)
		ANK	1039..1159	CDD:238125	34/127 (27%)
		ANK repeat	1043..1074	CDD:293786	10/30 (33%)
		Ank_2	1048..1135	CDD:289560	24/86 (28%)
		ANK repeat	1076..1101	CDD:293786	9/24 (38%)
		ANK repeat	1109..1134	CDD:293786	1/24 (4%)
		Ion_trans	<1393..1598	CDD:278921
tnks	XP_004911090.1	Ank_4	164..214	CDD:290365	15/52 (29%)
		ANK	186..300	CDD:238125	38/158 (24%)
		ANK repeat	196..224	CDD:293786	13/66 (20%)
		Ank_2	198..290	CDD:289560	33/133 (25%)
		ANK repeat	226..257	CDD:293786	11/32 (34%)
		ANK repeat	259..290	CDD:293786	8/31 (26%)
		Ank_4	317..367	CDD:290365	13/66 (20%)
		ANK	339..453	CDD:238125	36/158 (23%)
		ANK repeat	349..377	CDD:293786	11/61 (18%)
		Ank_2	351..443	CDD:289560	31/136 (23%)
		ANK repeat	379..410	CDD:293786	10/30 (33%)
		ANK repeat	412..443	CDD:293786	11/41 (27%)
		ANK repeat	501..533	CDD:293786	15/80 (19%)
		Ank_2	504..598	CDD:289560	36/182 (20%)
		ANK	530..716	CDD:238125	59/226 (26%)
		ANK repeat	535..566	CDD:293786	9/70 (13%)
		ANK repeat	568..598	CDD:293786	11/29 (38%)
		ANK	655..780	CDD:238125	47/162 (29%)
		ANK repeat	665..693	CDD:293786	12/27 (44%)
		Ank_2	667..759	CDD:289560	37/128 (29%)
		ANK repeat	695..726	CDD:293786	12/52 (23%)
		ANK repeat	728..759	CDD:293786	13/45 (29%)
		ANK repeat	781..811	CDD:293786	7/43 (16%)
		Ank_4	782..836	CDD:290365	20/112 (18%)
		ANK	808..932	CDD:238125	45/183 (25%)
		ANK repeat	815..846	CDD:293786	15/76 (20%)
		Ank_2	820..912	CDD:289560	39/127 (31%)
		ANK repeat	848..879	CDD:293786	10/30 (33%)
		ANK repeat	881..912	CDD:293786	12/30 (40%)
		SAM_tankyrase1,2	1003..1068	CDD:188923	4/15 (27%)
		SAM	1009..1066	CDD:197735	2/9 (22%)
		tankyrase_like	1070..1292	CDD:238718
		PARP	1090..1287	CDD:279038
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1759
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940