DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nompC and Poteh

DIOPT Version :9

Sequence 1:	NP_523483.2	Gene:	nompC / 33768	FlyBaseID:	FBgn0016920	Length:	1761	Species:	Drosophila melanogaster
Sequence 2:	XP_006251849.1	Gene:	Poteh / 100363368	RGDID:	2323175	Length:	1085	Species:	Rattus norvegicus

Alignment Length:	1071	Identity:	192/1071 - (17%)
Similarity:	331/1071 - (30%)	Gaps:	343/1071 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   301 GQTPLHIAAAEGDEALLKYFYGVRAS-ASIADNQDRTPMHLAAENGHAHVIEILADKFKASIFER 364
            ||  ||.||:.|..|.::.|...|.: .:..|.::||.:|.|..:||..|:.:|.:: ..::..|
  Rat    23 GQ--LHRAASVGAVATVERFLTFRLNGVNDTDKRNRTALHYACAHGHLGVVTLLIER-NCNVNAR 84

  Fly   365 TKDGSTLMHIASLNGHAECATMLFKKGVYLHMPNKDGARSIHTAAAYGHTGIINTLLQKGEKVDV 429
            ..|..|.:..||.:...:|..:|.:.|...:..:..|..::|.|....:..|.:.||:....::.
  Rat    85 DDDKCTPLIKASQHQREDCVAVLLQHGADPNAVDALGNTALHYAVHSENASIASQLLEHSANIEA 149

  Fly   430 TTNDNYTALHIAVESAKPAVVETLLGFGADVHV-------------RGGKLRETPLHIAARVKDG 481
            .|.:.:|.|.:||:..:..:||.|:..||:.|.             .|...::...::  .:||.
  Rat   150 RTKEGFTPLSLAVQQNRGPIVELLIEKGANKHTVFRLDRSSCRFGPDGSSRKKDDSNV--DIKDE 212

  Fly   482 DRCALMLLKSGASPNLTTDDCLTPVHVAARHGNLATLMQLLEDEGDPLYKSNTGETPLHMACRAC 546
            ......:.:..||....|:  |.|.|       |.|..|    |.....|.:||..|.|..
  Rat   213 AALKTSIPRQKASKARQTN--LQPDH-------LRTTSQ----EQKEKRKCDTGHRPAHSG---- 260

  Fly   547 HPDI-------------------VRHLIETVKEKHGPDKATTYINSVNEDGATALHYTCQITKEE 592
            .|.:                   :|..:|..:::..|..:|...:|.:|:            :.:
  Rat   261 RPPMKTAEEAQQSKQLTKVLRSKLRTFLEPSEKEPPPSISTGKAHSKDEE------------ERK 313

  Fly   593 VKIPESDKQIVRMLLENGADVTLQTKTALETAFHYCAVAGNNDVLMEMISHMNPTDIQKAMNRQS 657
            .::.|.|     :.|||..|.|:.|..:...|  ..||:.:........|....:.|..|....:
  Rat   314 YRLQELD-----VALENSDDRTVCTVASASAA--AAAVSASTSAESASTSASAASRIASAAFASA 371

  Fly   658 SVGWTPLLIACHRGHMELVNNLLANHARVDVFDTEGRSALHLAAERGYLHVCDALLTNKAFINSK 722
            |.......:|               .|......|...||...|:|..   ...|..:..|:..|.
  Rat   372 SAASASASVA---------------FASASAASTSAASASASASEAS---AAAAAASISAYDASA 418

  Fly   723 SRVGRTALHLAAMNGFTHLVKFLIKDHNAVIDILTLRKQTPLHLAAASGQMEVCQLLLELGANID 787
            :.....|...|..:             |..::.:.....|...:|.|:
  Rat   419 AAAAAAAASAATSS-------------NTTVNAVVAAAVTAAFVAVAA----------------- 453

  Fly   788 ATDDLGQKPI---HVAAQNNYSEVAKLFLQQHPSLVNATSKDGNTCAHIAAMQGSVKVIEELMKF 849
            ..:..|.:||   |..|.|:...|.|...:|..|         ....|             ||:.
  Rat   454 TAEHKGDEPIPQRHSGATNDRDFVLKEKEEQDKS---------EPATH-------------LMEI 496

  Fly   850 DRSGVISARNKLT---DATPLQLAAEGGHADVVKALVRAGASCTEENKAGFTAVHLAAQNGHGQV 911
            :||     .||.:   |:.|                  ...:||.:..|........|:..|...
  Rat   497 NRS-----ENKNSFPGDSMP------------------TFETCTADTSAMLQVKQSCARELHQDD 538

  Fly   912 LDVLKSTNSLRINSKKLGLTPLHVAAYYGQADTVRELLTSVPATVKSETPTGQSLFGDLGTESGM 976
            ....|:|:..:...|||                                    ..||: |.|.|.
  Rat   539 RRYAKNTSKEKHEVKKL------------------------------------KNFGE-GLEDGT 566

  Fly   977 TPLHLAAFSGNEN------------VVRLLLNSAGVQVDAATIENGYNPL-----------HLAC 1018
            .|...|:....::            ..|||           .|:|.|..:           |
  Rat   567 LPCEAASDDYRDSGCLLGLWDELYLCKRLL-----------EIKNSYGDVLRREIKKMETKH--- 617

  Fly  1019 FGGHMSVVGLLLSRSAELLQSQDRNGRTGLHIAAMHGHIQMVEILLGQGAEINATDRNGWTPLHC 1083
             ||    |...||:..|:|...:|.......:..:...::..|.::..|    ..|....|.|..
  Rat   618 -GG----VRKELSKITEVLSQPERQETEWGELCNLRSSLKQNENIINDG----CFDGKMKTELRG 673

  Fly  1084 AAKAGHLEVVKLLCEAGASPKSETNYGCAAIWFAASE----GHNEV----LRYLMNKEHDTYGLM 1140
            ..:..|.|                 :|.:.::...:|    |.:|:    |...:...||:...:
  Rat   674 RERQYHEE-----------------FGRSPLYHQCNEEFEVGQHEMSLGNLNMNLKALHDSVTQL 721

  Fly  1141 EDKRFVYNLMVVSKNHNNKPIQEFVLVSPAPVDTAAKLSNIYIVLSTKEKERAKDLVAAGKQCEA 1205
            ::.:.           .:.|.:|.||.|........||....:.|....|.:|:::       |.
  Rat   722 QEAQL-----------QDDPQREGVLSSARMAHLLWKLEVDCLKLEDSVKNQAEEI-------EE 768

  Fly  1206 MATELLALAAGSDS-----------------------------------------AGKILQATDK 1229
            :.|:||.:....|.                                         |||.|...:.
  Rat   769 LETQLLTVELTGDRKKERDEVTRSTQSLACALEHEVEKIEELEKTLHGFMEVMKIAGKKLDECEN 833

  Fly  1230 RNVEFLDVLIENEQKEVIAHTVVQRYLQELW 1260
            |.:.|.:.: .|...|.:.|.:  .||::.|
  Rat   834 RELYFYEDM-RNRTFETLQHEI--NYLKDTW 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nompC	NP_523483.2	ANK repeat	129..157	CDD:293786
		Ank_2	131..228	CDD:289560
		ANK	155..319	CDD:238125	8/17 (47%)
		ANK repeat	159..186	CDD:293786
		ANK repeat	232..265	CDD:293786
		Ank_2	237..331	CDD:289560	10/30 (33%)
		ANK	263..387	CDD:238125	25/86 (29%)
		ANK repeat	267..298	CDD:293786
		ANK repeat	300..331	CDD:293786	10/30 (33%)
		Ank_2	305..398	CDD:289560	25/93 (27%)
		ANK	329..454	CDD:238125	30/124 (24%)
		ANK repeat	367..398	CDD:293786	7/30 (23%)
		ANK repeat	400..431	CDD:293786	6/30 (20%)
		Ank_2	405..498	CDD:289560	21/105 (20%)
		ANK	428..555	CDD:238125	31/158 (20%)
		ANK repeat	433..463	CDD:293786	10/42 (24%)
		ANK repeat	469..499	CDD:293786	4/29 (14%)
		ANK	496..641	CDD:238125	31/163 (19%)
		ANK repeat	501..532	CDD:293786	7/30 (23%)
		Ank_2	507..616	CDD:289560	24/127 (19%)
		ANK repeat	534..575	CDD:293786	10/59 (17%)
		ANK repeat	577..616	CDD:293786	7/38 (18%)
		Ank_2	625..722	CDD:289560	15/96 (16%)
		ANK	654..780	CDD:238125	17/125 (14%)
		ANK repeat	660..690	CDD:293786	2/29 (7%)
		ANK repeat	692..723	CDD:293786	7/30 (23%)
		Ank_2	697..790	CDD:289560	11/92 (12%)
		ANK	720..847	CDD:238125	18/129 (14%)
		ANK repeat	725..757	CDD:293786	3/31 (10%)
		ANK repeat	759..790	CDD:293786	3/30 (10%)
		Ank_5	779..834	CDD:290568	11/57 (19%)
		ANK	787..915	CDD:238125	24/133 (18%)
		ANK repeat	792..824	CDD:293786	10/34 (29%)
		ANK repeat	861..893	CDD:293786	4/34 (12%)
		Ank_4	865..915	CDD:290365	6/49 (12%)
		Ank_4	929..995	CDD:290365	9/77 (12%)
		ANK repeat	932..972	CDD:293786	2/39 (5%)
		ANK	969..1096	CDD:238125	27/149 (18%)
		ANK repeat	974..1007	CDD:293786	6/44 (14%)
		Ank_2	979..1074	CDD:289560	18/117 (15%)
		ANK repeat	1009..1041	CDD:293786	10/42 (24%)
		ANK	1039..1159	CDD:238125	15/127 (12%)
		ANK repeat	1043..1074	CDD:293786	2/30 (7%)
		Ank_2	1048..1135	CDD:289560	12/94 (13%)
		ANK repeat	1076..1101	CDD:293786	4/24 (17%)
		ANK repeat	1109..1134	CDD:293786	5/32 (16%)
		Ion_trans	<1393..1598	CDD:278921
Poteh	XP_006251849.1	Ank_4	25..75	CDD:290365	16/49 (33%)
		ANK repeat	25..52	CDD:293786	8/26 (31%)
		ANK	49..174	CDD:238125	30/125 (24%)
		ANK repeat	54..85	CDD:293786	8/31 (26%)
		Ank_2	59..150	CDD:289560	20/91 (22%)
		ANK repeat	87..118	CDD:293786	7/30 (23%)
		ANK repeat	120..150	CDD:293786	6/29 (21%)
		Ank_5	140..>179	CDD:290568	11/38 (29%)
		ANK repeat	153..183	CDD:293786	10/29 (34%)
		DUF3496	939..1038	CDD:288825
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010