DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12512 and acs

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_418493.1	Gene:	acs / 948572	ECOCYCID:	EG11448	Length:	652	Species:	Escherichia coli

Alignment Length:	604	Identity:	122/604 - (20%)
Similarity:	220/604 - (36%)	Gaps:	148/604 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 GDVEAIV----SCHEGKRYSFKSLLQEADALAAGFRKLGLQPGDAVGLWAPNYLHWYLGMMGAAR 121
            ||..||:    ...:.|..|:|.|.::....|....:||::.||.|.::.|......:.|:..||
E. coli    90 GDRTAIIWEGDDASQSKHISYKELHRDVCRFANTLLELGIKKGDVVAIYMPMVPEAAVAMLACAR 154

  Fly   122 AGLTSVGLNPAYQGPEIAYCLNKVNVKAIIAPETFKTQNYYEILRDICPEISDADTGKIRSEKFP 186
            .|.....:...:....:|..:...|.:.:|.                      :|.|.......|
E. coli   155 IGAVHSVIFGGFSPEAVAGRIIDSNSRLVIT----------------------SDEGVRAGRSIP 197

  Fly   187 HLRSVIIDSNDSLKGA-------------------------LRFDDFLDLASKSEREEVAKMQKS 226
            ..::|    :|:||..                         |.:.|.::.||...:.|....:..
E. coli   198 LKKNV----DDALKNPNVTSVEHVVVLKRTGGKIDWQEGRDLWWHDLVEQASDQHQAEEMNAEDP 258

  Fly   227 ILPESACNIQFTSGTTGNPKAACLTHHNFV-----------------------NNGIHVGNRNEL 268
            :.      |.:|||:||.||....|...::                       :.|...|:...|
E. coli   259 LF------ILYTSGSTGKPKGVLHTTGGYLVYAALTFKYVFDYHPGDIYWCTADVGWVTGHSYLL 317

  Fly   269 EGERICVQVPMFHAFGVIISIMAALTKGATMVL-------PAAGFSPKDSLQAIVNEKCSVIHGT 326
            .|...|                     |||.::       |    :|....|.:...:.::::..
E. coli   318 YGPLAC---------------------GATTLMFEGVPNWP----TPARMAQVVDKHQVNILYTA 357

  Fly   327 PTMYVDLVNTQKKLQVPLGRIKKAVTGGAIVSPQLIKDVRQVLNVEA--------------VHSV 377
            ||          .::..:....||:.|....|.:::..|.:.:|.||              |...
E. coli   358 PT----------AIRALMAEGDKAIEGTDRSSLRILGSVGEPINPEAWEWYWKKIGNEKCPVVDT 412

  Fly   378 YGLTETTAVIFQSLPGDSSDVVLNSVGHLTDHIEAKVVDAEGRCVPFGQPGELCVRG-----YTT 437
            :..|||...:...||| ::::...|.......::..:||.||..:.....|.|.:..     ..|
E. coli   413 WWQTETGGFMITPLPG-ATELKAGSATRPFFGVQPALVDNEGNPLEGATEGSLVITDSWPGQART 476

  Fly   438 MLGYHDDEEKTKETIGNDRWLRTGDQFVLEANGYGRIVGRLKEMLIRGGENIFPKEIEDFLNAHP 502
            :.|.|:..|:|..:...:.:. :||....:.:||..|.||:.::|...|..:...|||..|.|||
E. coli   477 LFGDHERFEQTYFSTFKNMYF-SGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHP 540

  Fly   503 QVIEAHVIGVPDERLGEEVCAYVRLEEGVDPASFTAETLKAYAKGKLAHFKVPRYVIPIDAFPKT 567
            ::.||.|:|:|....|:.:.|||.|..|.:|:......::.:.:.::.....|..:...|:.|||
E. coli   541 KIAEAAVVGIPHNIKGQAIYAYVTLNHGEEPSPELYAEVRNWVRKEIGPLATPDVLHWTDSLPKT 605

  Fly   568 TSGKIQKFKLVEAFKAKET 586
            .||||.: :::....|.:|
E. coli   606 RSGKIMR-RILRKIAAGDT 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	122/604 (20%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	86/396 (22%)
acs	NP_418493.1	PRK00174	6..649	CDD:234677	122/604 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
	2	1.910