DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12512 and menE

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_416763.1	Gene:	menE / 946741	ECOCYCID:	EG12437	Length:	451	Species:	Escherichia coli

Alignment Length:	521	Identity:	124/521 - (23%)
Similarity:	206/521 - (39%)	Gaps:	115/521 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 KRYSFKSLLQEADALAAGFRKLGLQPGDAVGLWAPNYLHWYLGMMGAARAGLTSVGLNPAYQGPE 137
            ::.:::.|....|.||:||...|:..|..|.|.|.|.....|..:...:.|...:.:||....|.
E. coli    26 EQLNWRELCARVDELASGFAVQGVVEGSGVMLRAWNTPQTLLAWLALLQCGARVLPVNPQLPQPL 90

  Fly   138 IAYCLNKVNVKAIIAPETFKTQNYYEILRDICPEISDADTGKIRSEKFPHLRSVIIDSNDSLKGA 202
            :...|..:.::..:.|:...|                          ||.|.|:.|   ..::||
E. coli    91 LEELLPNLTLQFALVPDGENT--------------------------FPALTSLHI---QLVEGA 126

  Fly   203 LRFDDFLDLASKSEREEVAKMQKSILPESACNIQFTSGTTGNPKAACLTHHNFVNNG------IH 261
                            ..|..|    |...|::..|||:||.||||..|:...:.:.      |.
E. coli   127 ----------------HAATWQ----PTRLCSMTLTSGSTGLPKAAVHTYQAHLASAQGVLSLIP 171

  Fly   262 VGNRNELEGERICVQVPMFHAFGVIISIMAALTKGATMVLPAAGFSPKDSLQAIVNEKCSVIHGT 326
            .|:.::.     .:.:|:||..|..| :...|..||.|.:     ..|..|:.:: ..|:.....
E. coli   172 FGDHDDW-----LLSLPLFHVSGQGI-MWRWLYAGARMTV-----RDKQPLEQML-AGCTHASLV 224

  Fly   327 PTMYVDLVNTQKKLQVPLGRIKKAVTGGAIVSPQLIKDVRQVLNVEAVHSV--YGLTE-TTAVIF 388
            ||....|:..:..:.     :|..:.|||.:..:|.:..|:    :.:...  ||||| .:.|..
E. coli   225 PTQLWRLLVNRSSVS-----LKAVLLGGAAIPVELTEQARE----QGIRCFCGYGLTEFASTVCA 280

  Fly   389 QSLPGDSSDVVLNSVGHLTDHIEAKVVDAEGRCVPFGQPGELCVRGYTTMLGYHDDEEKTKETIG 453
            :...|      |..||......|.|:|:           .|:.:|..:...||..:.:.. ..:.
E. coli   281 KEADG------LADVGSPLPGREVKIVN-----------NEVWLRAASMAEGYWRNGQLV-SLVN 327

  Fly   454 NDRWLRTGDQFVLEANGYGRIVGRLKEMLIRGGENIFPKEIEDFLNAHPQVIEAHVIGVPDERLG 518
            ::.|..|.|:..:. ||...|||||..:...|||.|.|:|:|..:.|||.|::..::.|.|:..|
E. coli   328 DEGWYATRDRGEMH-NGKLTIVGRLDNLFFSGGEGIQPEEVERVIAAHPAVLQVFIVPVADKEFG 391

  Fly   519 EEVCAYVRLE-EGVDPASFTAETLKAYAKGKLAHFKVP-RYV-IPIDAFPKTTSG--KIQKFKLV 578
            ....|.:..: |.||        |..:.|.|||.|:.| |:: :|    |:..:|  ||.:..|.
E. coli   392 HRPVAVMEYDHESVD--------LSEWVKDKLARFQQPVRWLTLP----PELKNGGIKISRQALK 444

  Fly   579 E 579
            |
E. coli   445 E 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	124/521 (24%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	93/361 (26%)
menE	NP_416763.1	PRK09029	1..451	CDD:236363	124/521 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100107
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
	2	1.800