DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12512 and fadD

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_416319.1	Gene:	fadD / 946327	ECOCYCID:	EG11530	Length:	561	Species:	Escherichia coli

Alignment Length:	574	Identity:	175/574 - (30%)
Similarity:	276/574 - (48%)	Gaps:	66/574 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 DPLVYRTIGQQLELSASNFGDVEAIVSCHEGKRYSFKSLLQEADALAAGFRK-LGLQPGDAVGLW 105
            :|..|:::....|.|.:.:.|..|.|:.  |:..:|:.|.:.:.|.||..:: |||:.||.|.|.
E. coli    18 NPDRYQSLVDMFEQSVARYADQPAFVNM--GEVMTFRKLEERSRAFAAYLQQGLGLKKGDRVALM 80

  Fly   106 APNYLHWYLGMMGAARAGLTSVGLNPAYQGPEIAYCLNKVNVKAIIAPETF---------KTQNY 161
            .||.|.:.:.:.|..|||:..|.:||.|...|:.:.||.....||:....|         ||...
E. coli    81 MPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGASAIVIVSNFAHTLEKVVDKTAVQ 145

  Fly   162 YEILRDICPEISDADTGKIRSEKFPHLRSVIIDSNDSLKGALRFDDFLDLASKSEREEVAKMQ-- 224
            :.||..:..::|.| .|.:.:....:::.::  ....|..|:.|        :|......:||
E. coli   146 HVILTRMGDQLSTA-KGTVVNFVVKYIKRLV--PKYHLPDAISF--------RSALHNGYRMQYV 199

  Fly   225 -KSILPESACNIQFTSGTTGNPKAACLTHHNFVNN--------G--IHVGNRNELEGERICVQVP 278
             ..::||....:|:|.||||..|.|.|||.|.:.|        |  :|.|.      |.:...:|
E. coli   200 KPELVPEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGPLLHPGK------ELVVTALP 258

  Fly   279 MFHAFGVIISIMAALTKGATMVLPAAGFSPKDSLQAIVNEKC----SVIHGTPTMYVDLVNTQKK 339
            ::|.|.:.|:.:..:..|...:|..   :|:| :..:|.|..    :.|.|..|::..|:|.::.
E. coli   259 LYHIFALTINCLLFIELGGQNLLIT---NPRD-IPGLVKELAKYPFTAITGVNTLFNALLNNKEF 319

  Fly   340 LQVPLGRIKKAVTGG----AIVSPQLIKDVRQVLNVEAVHSVYGLTETTAVIFQSLPGDSSDVVL 400
            .|:....:..:..||    .:|:.:.:|...|.| :|.    |||||...::  |:.....|...
E. coli   320 QQLDFSSLHLSAGGGMPVQQVVAERWVKLTGQYL-LEG----YGLTECAPLV--SVNPYDIDYHS 377

  Fly   401 NSVGHLTDHIEAKVVDAEGRCVPFGQPGELCVRGYTTMLGYHDDEEKTKETIGNDRWLRTGDQFV 465
            .|:|......|||:||.:...||.||||||||:|...||||....:.|.|.|.|. ||.|||..|
E. coli   378 GSIGLPVPSTEAKLVDDDDNEVPPGQPGELCVKGPQVMLGYWQRPDATDEIIKNG-WLHTGDIAV 441

  Fly   466 LEANGYGRIVGRLKEMLIRGGENIFPKEIEDFLNAHPQVIEAHVIGVPDERLGEEVCAYVRLEEG 530
            ::..|:.|||.|.|:|::..|.|::|.||||.:..||.|.|...:|||....||.|..:|..:
E. coli   442 MDEEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGEAVKIFVVKK-- 504

  Fly   531 VDPASFTAETLKAYAKGKLAHFKVPRYVIPIDAFPKTTSGKIQKFKLVEAFKAK 584
             || |.|.|:|..:.:.:|..:|||:.|...|..||:..|||.:.:|.:..:.|
E. coli   505 -DP-SLTEESLVTFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARGK 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	175/573 (31%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	123/365 (34%)
fadD	NP_416319.1	PRK08974	1..560	CDD:236359	175/574 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004397
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100107
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X154
SwiftOrtho	1	1.000	-	-
	6	5.710