DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12512 and fadK

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_416216.5	Gene:	fadK / 946213	ECOCYCID:	EG12357	Length:	566	Species:	Escherichia coli

Alignment Length:	575	Identity:	160/575 - (27%)
Similarity:	270/575 - (46%)	Gaps:	67/575 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 HIGKDPL------------------VYRTIGQQLELSASNF--------GDVEAIVSCHEGKRYS 76
            |:|.|.|                  .||..|...:.|.:::        .|..|:|..| |..|:
E. coli     7 HLGPDVLFRESNMKVTLTFNEQRRAAYRQQGLWGDASLADYWQQTARAMPDKIAVVDNH-GASYT 70

  Fly    77 FKSLLQEADALAAGFRKLGLQPGDAVGLWAPNYLHWYLGMMGAARAGLTSVGLNPAYQGPEIAYC 141
            :.:|...|..||......|::.||.:....|.:..:.:..:...:.|..||.|.|:::..|:.:.
E. coli    71 YSALDHAASCLANWMLAKGIESGDRIAFQLPGWCEFTVIYLACLKIGAVSVPLLPSWREAELVWV 135

  Fly   142 LNKVNVKAIIAPETFKTQNYYEILRDICPEISDADTGKIRSEKFPHLRSVI-ID------SNDSL 199
            |||...|...||..||.....:::..:             ..:.|.|:.:: :|      |:.||
E. coli   136 LNKCQAKMFFAPTLFKQTRPVDLILPL-------------QNQLPQLQQIVGVDKLAPATSSLSL 187

  Fly   200 KGALRFDDFLDLASKSEREEVAKMQKSILPESACNIQFTSGTTGNPKAACLTHHNFV-NNGIHVG 263
            ...:..:..|..|..:..:|:|.            :.|||||.|.||...|||:|.: :...:..
E. coli   188 SQIIADNTSLTTAITTHGDELAA------------VLFTSGTEGLPKGVMLTHNNILASERAYCA 240

  Fly   264 NRNELEGERICVQVPMFHAFGVIISIMAALTKGATMVLPAAGFSPKDSLQAIVNEKCSVIHG-TP 327
            ..|....:...:..|:.||.|.:..:.|....||..||... |:|...|..:..::|:.:.| ||
E. coli   241 RLNLTWQDVFMMPAPLGHATGFLHGVTAPFLIGARSVLLDI-FTPDACLALLEQQRCTCMLGATP 304

  Fly   328 TMYVDLVNTQKKLQVPLGRIKKAVTGGAIVSPQLIKDVRQVLNVEAVHSVYGLTETTAVIFQSLP 392
            .:| ||:|..:|....|..::..:.||..:..::.::.:| ..::.: ||||.||::.....:|
E. coli   305 FVY-DLLNVLEKQPADLSALRFFLCGGTTIPKKVARECQQ-RGIKLL-SVYGSTESSPHAVVNL- 365

  Fly   393 GDSSDVVLNSVGHLTDHIEAKVVDAEGRCVPFGQPGELCVRGYTTMLGYHDDEEKTKETIGNDRW 457
            .|.....:::.|:....:|.||||...:.:|.|..||...||....:||.|:.|.|...:..:.|
E. coli   366 DDPLSRFMHTDGYAAAGVEIKVVDDARKTLPPGCEGEEASRGPNVFMGYFDEPELTARALDEEGW 430

  Fly   458 LRTGDQFVLEANGYGRIVGRLKEMLIRGGENIFPKEIEDFLNAHPQVIEAHVIGVPDERLGEEVC 522
            ..:||...::..||.:|.||.|::::||||||..:|:||.|..||::.:|.|:.:.||||||..|
E. coli   431 YYSGDLCRMDEAGYIKITGRKKDIIVRGGENISSREVEDILLQHPKIHDACVVAMSDERLGERSC 495

  Fly   523 AYVRLEEGVDPASFTAETLKAYAKGKLAHFKVPRYVIPIDAFPKTTSGKIQKFKL 577
            |||.|:......|. .|.:..:::.::|.:|.|.:::.|:..|:|||||||||.|
E. coli   496 AYVVLKAPHHSLSL-EEVVAFFSRKRVAKYKYPEHIVVIEKLPRTTSGKIQKFLL 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	157/570 (28%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	113/349 (32%)
fadK	NP_416216.5	PRK06087	20..566	CDD:180393	156/562 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	64	1.000	Domainoid score	I563
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	205	1.000	Inparanoid score	I157
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004397
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100107
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
	6	5.760