DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12512 and entF

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_415118.1	Gene:	entF / 945184	ECOCYCID:	EG10264	Length:	1293	Species:	Escherichia coli

Alignment Length:	621	Identity:	144/621 - (23%)
Similarity:	233/621 - (37%)	Gaps:	119/621 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 PSLISHKHHI-------GKDPLV------YRTIGQQLELSASNFGDVE-------AIVSCHEGK- 73
            |:||.|...:       ..||.:      ....|:..:|:..|...||       |:|:....|
E. coli   404 PTLIQHAERLKMLIAQFAADPALLCGDVDIMLPGEYAQLAQLNATQVEIPETTLSALVAEQAAKT 468

  Fly    74 ---------RY--SFKSLLQEADALAAGFRKLGLQPGDAVGLWAPNYLHWYLGMMGAARAGLTSV 127
                     ||  |::.:.::..|||...|:.|::|||:|.:..|..:...|.:.....||...:
E. coli   469 PDAPALADARYLFSYREMREQVVALANLLRERGVKPGDSVAVALPRSVFLTLALHAIVEAGAAWL 533

  Fly   128 GLNPAYQGPEIAYCLNKVNVKAIIAPETFKTQNYYEILRDICPEISDADTGKIRSEKFPHLRSVI 192
            .|:..|....:...|.......:|..:            |..|..||.          |:|.|:.
E. coli   534 PLDTGYPDDRLKMMLEDARPSLLITTD------------DQLPRFSDV----------PNLTSLC 576

  Fly   193 IDSNDSLKGALRFDDFLDLASKSEREEVAKMQKSILPESACNIQFTSGTTGNPKAACLTHHNFVN 257
            .::..:.:|:                  |.:|.| .|.....|.||||:||.||...:.....||
E. coli   577 YNAPLTPQGS------------------APLQLS-QPHHTAYIIFTSGSTGRPKGVMVGQTAIVN 622

  Fly   258 NGIHVGNRNELEGERICVQ-------VPMFHAFGVIISIMAALTKGATMVL--PAAGFSPKDSLQ 313
            ..:.:.|...|.||.:..|       |.::..|...|:       ||.:|:  |.|...|....|
E. coli   623 RLLWMQNHYPLTGEDVVAQKTPCSFDVSVWEFFWPFIA-------GAKLVMAEPEAHRDPLAMQQ 680

  Fly   314 AIVNEKCSVIHGTPTMYVDLVN--TQKKLQVPLGRIKKAVTGGAIVSPQLIKDVRQVLNVEAVHS 376
            .......:..|..|:|....|.  |.:..:.....:|:....|..:...|.::.:| |....:|:
E. coli   681 FFAEYGVTTTHFVPSMLAAFVASLTPQTARQSCATLKQVFCSGEALPADLCREWQQ-LTGAPLHN 744

  Fly   377 VYGLTETTAVIFQSLP--GDSSDVVLNS---VGHLTDHIEAKVVDAEGRCVPFGQPGELCVRGYT 436
            :||.|| .||.....|  |:....|..|   :|:...:...:::||....||.|..|:|.:.|..
E. coli   745 LYGPTE-AAVDVSWYPAFGEELAQVRGSSVPIGYPVWNTGLRILDAMMHPVPPGVAGDLYLTGIQ 808

  Fly   437 TMLGYHDDEEKTKETI------GNDRWLRTGDQFVLEANGYGRIVGRLKEMLIRGGENIFPKEIE 495
            ...||....:.|....      ..:|..||||......||....:||..:.|...|:.|...||:
E. coli   809 LAQGYLGRPDLTASRFIADPFAPGERMYRTGDVARWLDNGAVEYLGRSDDQLKIRGQRIELGEID 873

  Fly   496 DFLNAHPQVIEA--H--VIGVPDERLGE--EVCAYVRLEEGVDPASFTAETLKAYAKGKLAHFKV 554
            ..:.|.|.|.:|  |  ||.......|:  ::..|:..:.|: |...:|  |:|..:..|....|
E. coli   874 RVMQALPDVEQAVTHACVINQAAATGGDARQLVGYLVSQSGL-PLDTSA--LQAQLRETLPPHMV 935

  Fly   555 PRYVIPIDAFPKTTSGKIQKFKLVEAFKAKETELKA 590
            |..::.:...|.:.:||:.:..|      ...||||
E. coli   936 PVVLLQLPQLPLSANGKLDRKAL------PLPELKA 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	139/601 (23%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	94/375 (25%)
entF	NP_415118.1	entF	1..1292	CDD:236668	144/621 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
	1	0.910