DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12512 and caiC

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_414579.4	Gene:	caiC / 944886	ECOCYCID:	EG11558	Length:	517	Species:	Escherichia coli

Alignment Length:	554	Identity:	144/554 - (25%)
Similarity:	224/554 - (40%)	Gaps:	79/554 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 GQQLELSASNFGDV----EAIVSCHEG---KRYSFKSLLQEADALAAGFRKLGLQPGDAVGLWAP 107
            ||.|.....:..||    .|::....|   .|||:..|.||.:..|..|..||::.||.|.|...
E. coli     6 GQHLRQMWDDLADVYGHKTALICESSGGVVNRYSYLELNQEINRTANLFYTLGIRKGDKVALHLD 70

  Fly   108 NYLHWYLGMMGAARAGLTSVGLNPAYQGPEIAYCLNKVNVKAIIAPETFKTQNYYEI-------L 165
            |...:.....|.|:.|...|.:|......|.|:.|.......::....|... |.:|       |
E. coli    71 NCPEFIFCWFGLAKIGAIMVPINARLLCEESAWILQNSQACLLVTSAQFYPM-YQQIQQEDATQL 134

  Fly   166 RDICPEISDADTGKIRSEKFPHLRSVIIDSNDSLKGALRFDDFLDLASKSEREEVAKMQKSILPE 230
            |.||                  |..|.:.::|.:      ..|..|  |:::.........:..:
E. coli   135 RHIC------------------LTDVALPADDGV------SSFTQL--KNQQPATLCYAPPLSTD 173

  Fly   231 SACNIQFTSGTTGNPKAACLTHHNFVNNGIHVGNRNELEGERICVQV-PMFHAFGVIISIMAALT 294
            ....|.||||||..||...:||:|....|.:...:..|..:.:.:.| |.||......:.|||.:
E. coli   174 DTAEILFTSGTTSRPKGVVITHYNLRFAGYYSAWQCALRDDDVYLTVMPAFHIDCQCTAAMAAFS 238

  Fly   295 KGATMVLPAAGFSPKDSLQAIVNEKCSVIHGTPTMYVDLVNTQKKLQVPLGRIKKAVTGGAIVSP 359
            .|||.|| ...:|.:.....:...:.:|....|.|...|:     :|.|          .|....
E. coli   239 AGATFVL-VEKYSARAFWGQVQKYRATVTECIPMMIRTLM-----VQPP----------SANDQQ 287

  Fly   360 QLIKDVRQVLNVE-------------AVHSVYGLTETTAVIFQSLPGDSSDVVLNSVGHLTDHIE 411
            ..:::|...||:.             .:.:.||:|||...|....|||...  ..|:|.:....|
E. coli   288 HRLREVMFYLNLSEQEKDAFCERFGVRLLTSYGMTETIVGIIGDRPGDKRR--WPSIGRVGFCYE 350

  Fly   412 AKVVDAEGRCVPFGQPGELCVRGY---TTMLGYHDDEEKTKETIGNDRWLRTGDQFVLEANGYGR 473
            |::.|...|.:|.|:.||:|::|.   |....|..:.:.|.:.:..|.||.|||....:...:..
E. coli   351 AEIRDDHNRPLPAGEIGEICIKGIPGKTIFKEYFLNPQATAKVLEADGWLHTGDTGYRDEEDFFY 415

  Fly   474 IVGRLKEMLIRGGENIFPKEIEDFLNAHPQVIEAHVIGVPDERLGEEVCAYVRLEEGVDPASFTA 538
            .|.|...|:.|||||:...|:|:.:.|||::.:..|:|:.|....|.:.|:|.|.||   .:.:.
E. coli   416 FVDRRCNMIKRGGENVSCVELENIIAAHPKIQDIVVVGIKDSIRDEAIKAFVVLNEG---ETLSE 477

  Fly   539 ETLKAYAKGKLAHFKVPRYVIPIDAFPKTTSGKI 572
            |....:.:..:|.||||.|:......|:..||||
E. coli   478 EEFFRFCEQNMAKFKVPSYLEIRKDLPRNCSGKI 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	144/554 (26%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	101/361 (28%)
caiC	NP_414579.4	caiC	1..517	CDD:181195	144/554 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100107
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
	3	2.710