DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12512 and CMR2

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_014736.1	Gene:	CMR2 / 854260	SGDID:	S000005619	Length:	1648	Species:	Saccharomyces cerevisiae

Alignment Length:	701	Identity:	115/701 - (16%)
Similarity:	216/701 - (30%)	Gaps:	268/701 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 YRTIGQQLELSASNFGDVEAIV----------------SCHEGKRYSFKSLLQEADALAAGF--- 91
            :::|.:.||...||:|:..|..                :.|  |:.|:.|.    ..:.|||
Yeast   979 FKSILEILEWRISNYGNETAFSDGTNTNLVNSSASNDNNVH--KKVSWASF----GKIVAGFLKK 1037

  Fly    92 ---RKLGLQPGDAVGLWAPNYLHWYLGMMGAARAGLTSVGLNPAYQGPEIAYCLNKVNVKAII-- 151
               .|:.|:.||.:.:...|.:.:...:|......|..:.|      |.:...:.:.::|.::
Yeast  1038 IVGSKIPLKHGDPIIIMCENSVEYVAMIMACLYCNLLVIPL------PSVKESVIEEDLKGLVNI 1096

  Fly   152 -----APETFKTQNYYEILRDICPEISDADTGKIRSEKFPHLRSVI----IDSNDSLKGALRFDD 207
                 ....|.....:.:|.|          ..:.::.|...:|:|    :.|....|.||....
Yeast  1097 IQSYKVKRVFVDAKLHSLLND----------NNVVNKCFKKYKSLIPKITVFSKVKTKNALTVSM 1151

  Fly   208 FLDLASKSEREEVAKMQKSILP-----------------ESACNIQFTSGTTGNPKAACLTHHNF 255
            |         :.|.|.:....|                 :...||..|           :||.:.
Yeast  1152 F---------KNVLKQKFGAKPGTRIGMTPCVVWVNTEYDVTSNIHVT-----------MTHSSL 1196

  Fly   256 VNNGIHVGNRNELEGERICVQVPMF------HAFGVIISIMAALTKGATMVLPAAGFS------- 307
            :|....|....:|....     |:|      ...|.:.|.:..:..||:..|    ||
Yeast  1197 LNASKIVKETLQLRNNS-----PLFSICSHTSGLGFMFSCLLGIYTGASTCL----FSLTDVLTD 1252

  Fly   308 PK------------------DSLQAIVNEKCSVIHG---------------TPTMYVDLVNTQKK 339
            ||                  ::|.|:::...|:|.|               :.::..|:....:.
Yeast  1253 PKEFLIGLQNLNVKDLYLKLETLYALLDRASSLIEGFKNKKENINSAKNNTSGSLREDVFKGVRN 1317

  Fly   340 LQVP---------LGRIKKAVTGGAIVSPQL----------IKDVRQVLNVEAVH---SVYGLTE 382
            :.:|         :..|.|..:..::...|:          :..:|..|::..|.   ..:.|.|
Yeast  1318 IMIPFPNRPRIYTIENILKRYSTISLSCTQISYVYQHHFNPLISLRSYLDIPPVDLYLDPFSLRE 1382

  Fly   383 TTAVIFQSLPGDSSD---VVLNSVGHLTDHIEAKVVDAEG--RCVPFGQPGELCVRGYTTMLGY- 441
              .:|.:..|.|.|.   :.:...|.:....:..||:.|.  .||. |:.||:..........|
Yeast  1383 --GIIREVNPNDVSAGNYIKIQDSGVVPVCTDVSVVNPETLLPCVD-GEFGEIWCCSEANAFDYF 1444

  Fly   442 ---------HDD-------EEKTKETIGND-RWLRTGDQFVLE----ANGYGRIV---------- 475
                     :.|       :.|.|..:.|. .:|||||...::    .|..|.:|
Yeast  1445 VCNSSKNKLYKDPFITEQFKSKMKSEVNNTLSYLRTGDLGFIKNVSCTNSQGEVVNLNLLFVLGS 1509

  Fly   476 ------------------------------------GRLKEMLIRGGE-------NIFPKEIEDF 497
                                                |.|...|||..|       |:....:.:.
Yeast  1510 IHESIEILGLTHFVSDLERTVKDVHSDIGSCLIAKAGGLLVCLIRCKERHNPILGNLTTLIVSEL 1574

  Fly   498 LNAHPQVIEAHVIGVPDERLGEEVCAYVRLEEGVDPASFTAETLKAYAKGK 548
            ||.|..::              ::|.:|| .:|:.|.: ::..::.:||.:
Yeast  1575 LNKHGVIL--------------DLCTFVR-TKGISPKN-SSMIMEVWAKNR 1609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	115/701 (16%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	78/485 (16%)
CMR2	NP_014736.1	DMAP_binding	5..121	CDD:368923
		AFD_class_I	179..893	CDD:418409
		Dip2	1004..1626	CDD:341231	108/676 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900