DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12512 and LYS2

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_009673.1	Gene:	LYS2 / 852412	SGDID:	S000000319	Length:	1392	Species:	Saccharomyces cerevisiae

Alignment Length:	590	Identity:	121/590 - (20%)
Similarity:	221/590 - (37%)	Gaps:	117/590 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 EGKRYSFKSLLQEADALAAGFRKLGLQPGDAVGLWAPNYLHWYLGMMGAARAGLTSVGLNPAYQG 135
            :.:.::::.:.:.::.:|....|.|::.||.|.:::...:...:.:||..:||.|...::|||..
Yeast   266 KSRSFTYRDINRTSNIVAHYLIKTGIKRGDVVMIYSSRGVDLMVCVMGVLKAGATFSVIDPAYPP 330

  Fly   136 PEIAYCLNKVNVKAIIAPETFKTQNYYEILRDICPEISDADTGKIRSEKFPHLRSVIIDSNDSLK 200
            ......|.....:.:|....  .....:::.|.   |:|      ..|....:.|:.|..|.:::
Yeast   331 ARQTIYLGVAKPRGLIVIRA--AGQLDQLVEDY---IND------ELEIVSRINSIAIQENGTIE 384

  Fly   201 GALRFDDFLDLASKSEREEVAKMQKSILPESACNIQFTSGTTGNPKAACLTHHNFVNNGIHVGNR 265
            |. :.|:..|:.:..:..:..:....:.|:|...:.||||:.|.||.....|.:.......:..|
Yeast   385 GG-KLDNGEDVLAPYDHYKDTRTGVVVGPDSNPTLSFTSGSEGIPKGVLGRHFSLAYYFNWMSKR 448

  Fly   266 -NELEGERIC---------VQVPMFHAFGVIISIMAALTKGATMVLPAAG--FSPKDSLQAIVNE 318
             |..|.::..         :|..||          ..|..||.:.:|...  .:|....:.:...
Yeast   449 FNLTENDKFTMLSGIAHDPIQRDMF----------TPLFLGAQLYVPTQDDIGTPGRLAEWMSKY 503

  Fly   319 KCSVIHGTPTMYVDLVNTQKKLQVPLGRIKKAVTGGAIVSPQLIKDVRQVLNVEA------VHSV 377
            .|:|.|.||.| ..|:..|  ...|..::..|...|.|::.      |..|.::.      :.::
Yeast   504 GCTVTHLTPAM-GQLLTAQ--ATTPFPKLHHAFFVGDILTK------RDCLRLQTLAENCRIVNM 559

  Fly   378 YGLTET-TAVIFQSLPGDSSDVVLNSVGHLTD---------HIEAKVVDAEGR---CVPFGQPGE 429
            ||.||| .||.:..:...:.|.  |.:..|.|         :::..||:...|   | ..|:.||
Yeast   560 YGTTETQRAVSYFEVKSKNDDP--NFLKKLKDVMPAGKGMLNVQLLVVNRNDRTQIC-GIGEIGE 621

  Fly   430 LCVRGYTTMLGYHDDEEKTKETIGN----------------------------DRWLRTGDQFVL 466
            :.||......||....|..||...|                            ||..||||....
Yeast   622 IYVRAGGLAEGYRGLPELNKEKFVNNWFVEKDHWNYLDKDNGEPWRQFWLGPRDRLYRTGDLGRY 686

  Fly   467 EANGYGRIVGRLKEMLIRGGENIFPKEIEDFLNAHPQVIEAHVI-------------------GV 512
            ..||.....||..:.:...|..|...||:..::.||.|.|...:                   ..
Yeast   687 LPNGDCECCGRADDQVKIRGFRIELGEIDTHISQHPLVRENITLVRKNADNEPTLITFMVPRFDK 751

  Fly   513 PDE--RLGEEVCAYVRLE---EGVDPASFTAETLKAYAKGKLAHFKVPRYVIPIDAFPKTTSGKI 572
            ||:  :...:|...|..:   :|:......::.::.:.|.:||.:.:|..::.:|..|...:||:
Yeast   752 PDDLSKFQSDVPKEVETDPIVKGLIGYHLLSKDIRTFLKKRLASYAMPSLIVVMDKLPLNPNGKV 816

  Fly   573 QKFKL 577
            .|.||
Yeast   817 DKPKL 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	121/590 (21%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	93/430 (22%)
LYS2	NP_009673.1	alpha_am_amid	7..1379	CDD:274582	121/590 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910