DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12512 and ACSS1

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_115890.2	Gene:	ACSS1 / 84532	HGNCID:	16091	Length:	689	Species:	Homo sapiens

Alignment Length:	685	Identity:	138/685 - (20%)
Similarity:	232/685 - (33%)	Gaps:	236/685 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 IGKDPLVYRT------------------IGQQLELSASNFGDVEAIVSC---HEGK--------- 73
            :.:|.||:.|                  :|.||.:|          |:|   |..|
Human    76 LARDTLVWDTPYHTVWDCDFSTGKIGWFLGGQLNVS----------VNCLDQHVRKSPESVALIW 130

  Fly    74 ---------RYSFKSLLQEADALAAGFRKLGLQPGDAVGLWAPNYLHWYLGMMGAARAGLTSVGL 129
                     |.:::.||:....||...::.|:..||.|.::.|........|:..||.|.....:
Human   131 ERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVAAMLACARIGAVHTVI 195

  Fly   130 NPAYQGPEIAYCLNKVNVKAIIAPETFKTQNYYEILRDICPEISDADTGKIRSEKFPHLRSVIID 194
            ...:....:|..:|....|.:|   ||..                    .:|..:...|:.::
Human   196 FAGFSAESLAGRINDAKCKVVI---TFNQ--------------------GLRGGRVVELKKIV-- 235

  Fly   195 SNDSLKG---------ALRFDDFL---DLASKSEREEVAKMQKSILPESACN-----IQFTSGTT 242
             ::::|.         |.|.|:.:   ||....| :|:||......|||..:     :.:|||:|
Human   236 -DEAVKHCPTVQHVLVAHRTDNKVHMGDLDVPLE-QEMAKEDPVCAPESMGSEDMLFMLYTSGST 298

  Fly   243 GNPKA-----------ACLTHHNFVNNGIHVGNRNELEGERICVQVPMFHAFGVIISI------- 289
            |.||.           |.|||                   ::.........||.:..|
Human   299 GMPKGIVHTQAGYLLYAALTH-------------------KLVFDHQPGDIFGCVADIGWITGHS 344

  Fly   290 ---MAALTKGATMVL-------PAAGFSPKDSLQAIVNEKCSVIHGTPT------MYVD--LVNT 336
               ...|..|||.||       |.||    ...:.:...|.:..:|.||      .|.|  :...
Human   345 YVVYGPLCNGATSVLFESTPVYPNAG----RYWETVERLKINQFYGAPTAVRLLLKYGDAWVKKY 405

  Fly   337 QKKLQVPLGRIKKAV---------------------------TGGAIVSPQLIKDVRQVLNVEAV 374
            .:.....||.:.:.:                           |||..::|:..::..::|...|:
Human   406 DRSSLRTLGSVGEPINCEAWEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGAEILPAMAM 470

  Fly   375 HSVYGLT-----ETTAV-----------IFQSLPGDSSDVVLNSVGHLTDHIEAKVVDAEGRCVP 423
            ...:|:.     |..:|           |.|:.||.:..:       ..||  .:.|||..:..|
Human   471 RPFFGIVPVLMDEKGSVVEGSNVSGALCISQAWPGMARTI-------YGDH--QRFVDAYFKAYP 526

  Fly   424 FGQPGELCVRGYTTMLGYHDDEEKTKETIGNDRWLRTGDQFVLEANGYGRIVGRLKEMLIRGGEN 488
                            ||:                .|||.......||.:|.||:.:::...|..
Human   527 ----------------GYY----------------FTGDGAYRTEGGYYQITGRMDDVINISGHR 559

  Fly   489 IFPKEIEDFLNAHPQVIEAHVIGVPDERLGEEVCAYVRLEEGVDPASFTAETLKAYAKGKLAHFK 553
            :...||||.:..||.|.|:.|||.|.:..||...|::.:::....:....:.||:....|:|.:.
Human   560 LGTAEIEDAIADHPAVPESAVIGYPHDIKGEAAFAFIVVKDSAGDSDVVVQELKSMVATKIAKYA 624

  Fly   554 VPRYVIPIDAFPKTTSGKIQKFKLVEAFKAKETEL 588
            ||..::.:...|||.|||:.:..|.:...::..||
Human   625 VPDEILVVKRLPKTRSGKVMRRLLRKIITSEAQEL 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	137/681 (20%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	91/431 (21%)
ACSS1	NP_115890.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	17..46
		Ac_CoA_lig_AcsA	54..676	CDD:274022	138/685 (20%)
		Coenzyme A binding. /evidence=ECO:0000250	224..227		1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910