DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12512 and AAE14

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001322322.1	Gene:	AAE14 / 839932	AraportID:	AT1G30520	Length:	560	Species:	Arabidopsis thaliana

Alignment Length:	556	Identity:	162/556 - (29%)
Similarity:	255/556 - (45%)	Gaps:	82/556 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 AIVSCHEGKRYSFKSLLQEADALAAGFRKLGLQPGDAVGLWAPN---YLHWYLGMMGAARAGLTS 126
            |:|:.:..::.:.:..:....:||||..:|||:.||.|.:.|.|   :|.|   ::..|..|...
plant    23 AVVTVYGNRKRTGREFVDGVLSLAAGLIRLGLRNGDVVSIAAFNSDLFLEW---LLAVALVGGVV 84

  Fly   127 VGLNPAYQGPEIAYCLNKVNVKAIIAPETFKTQNYYEILRDICPEISDADTGKIRSEKFPHLR-S 190
            ..||..:...|....:..|....::..||..:.         |.::.:.|        .|.|: .
plant    85 APLNYRWSLKEAKMAMLLVEPVLLVTDETCVSW---------CIDVQNGD--------IPSLKWR 132

  Fly   191 VIIDSNDSLKGALRFDDFLDLASKSEREEVAKMQKSILP---------ESACNIQFTSGTTGNPK 246
            |:::|..:        ||.:..::....|:.| |::::|         :.|..|.|||||||.||
plant   133 VLMESTST--------DFANELNQFLTTEMLK-QRTLVPSLATYAWASDDAVVICFTSGTTGRPK 188

  Fly   247 AACLTHHNFVNNGI-HVGNRNELEGERICVQVPMFHAFGVIISIMAALTKGATMVLPAAGFSPKD 310
            ...::|..|:...: .:......|.:......|:.| .|.:.|.||.|..||..|| ...|..|.
plant   189 GVTISHLAFITQSLAKIAIAGYGEDDVYLHTSPLVH-IGGLSSAMAMLMVGACHVL-LPKFDAKT 251

  Fly   311 SLQAIVNEKCSVIHGTPTMYVDL--VNTQKKLQVPLGRIKKAVTGGAIVSPQLIKDVRQVLNVEA 373
            :||.:.....:.....|.|..||  ||...|.......::|.:.||..:|.:|:|:...:.....
plant   252 ALQVMEQNHITCFITVPAMMADLIRVNRTTKNGAENRGVRKILNGGGSLSSELLKEAVNIFPCAR 316

  Fly   374 VHSVYGLTET-TAVIFQSL--PGDSSDVV----LNS------VGHLTDHIEAKV-VDAEGRCVPF 424
            :.|.||:||. :::.|.:|  |...|..|    ||.      ||....|||..| :|.:...|
plant   317 ILSAYGMTEACSSLTFMTLHDPTQESFKVTYPLLNQPKQGTCVGKPAPHIELMVKLDEDSSRV-- 379

  Fly   425 GQPGELCVRGYTTMLGY--H---DDEEKTKETIGNDRWLRTGDQFVLEANGYGRIVGRLKEMLIR 484
               |::..||..|||.|  |   .:..:|.|:..|:.||.|||....:..|...::||....:..
plant   380 ---GKILTRGPHTMLRYWGHQVAQENVETSESRSNEAWLDTGDIGAFDEFGNLWLIGRSNGRIKT 441

  Fly   485 GGENIFPKEIEDFLNAHPQVIEAHVIGVPDERLGEEVCAYVRLEE-----GVD--PASF--TAET 540
            ||||::|:|:|..|..||.::.|.||||.|.||||.|.|.|||:|     .|:  ..||  ::||
plant   442 GGENVYPEEVEAVLVEHPGIVSAVVIGVIDTRLGEMVVACVRLQEKWIWSDVENRKGSFQLSSET 506

  Fly   541 LKAYAKGK-LAHFKVP-RYVIPIDAFPKTTSGKIQK 574
            ||.:.:.: |..||:| |:|.....||.||:||:::
plant   507 LKHHCRTQNLTGFKIPKRFVRWEKQFPLTTTGKVKR 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	162/556 (29%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	127/388 (33%)
AAE14	NP_001322322.1	PLN02860	1..560	CDD:215464	162/556 (29%)
		AFD_class_I	42..>269	CDD:302604	63/257 (25%)
		AFD_class_I	172..546	CDD:302604	126/378 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386992at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR43201
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920