DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12512 and ACSF2

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001275897.1	Gene:	ACSF2 / 80221	HGNCID:	26101	Length:	640	Species:	Homo sapiens

Alignment Length:	567	Identity:	228/567 - (40%)
Similarity:	344/567 - (60%)	Gaps:	18/567 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 RSISTSMPSLISHKHHIGKDPLVYRTIGQQLELSASNFGDVEAIVSCHEGKRYSFKSLLQEADAL 87
            |.:||.:..| |:.....|..|..:|:||.||.:|....:.||:|..||..|.:|..|.:|.|..
Human    74 RMVSTPIGGL-SYVQGCTKKHLNSKTVGQCLETTAQRVPEREALVVLHEDVRLTFAQLKEEVDKA 137

  Fly    88 AAGFRKLGLQPGDAVGLWAPNYLHWYLGMMGAARAGLTSVGLNPAYQGPEIAYCLNKVNVKAIIA 152
            |:|...:||..||.:|:|.||...|.|..:..|:||:..|.:|||||..|:.|.|.||..||::.
Human   138 ASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKALVF 202

  Fly   153 PETFKTQNYYEILRDICPEISDADTGKIRSEKFPHLRSVI-IDSNDSLKGALRFDDFLDLASKSE 216
            |:.||||.||.:|:.||||:.:|..|.::|::.|.|.:|| :|:  .|.|.|..|:.  :|:.|.
Human   203 PKQFKTQQYYNVLKQICPEVENAQPGALKSQRLPDLTTVISVDA--PLPGTLLLDEV--VAAGST 263

  Fly   217 REEVAKM---QKSILPESACNIQFTSGTTGNPKAACLTHHNFVNNGIHVGNRNEL-----EGERI 273
            |:.:.::   |:.:......||||||||||:||.|.|:|:|.|||...:|.|.:|     |..|:
Human   264 RQHLDQLQYNQQFLSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQLRM 328

  Fly   274 CVQVPMFHAFGVIISIMAALTKGATMVLPAAGFSPKDSLQAIVNEKCSVIHGTPTMYVDLVNTQK 338
            .:..|::|..|.:...|..|..|||::|.:..|:.|.:|:||..|:.:.::|||||:||::|...
Human   329 ILPNPLYHCLGSVAGTMMCLMYGATLILASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPD 393

  Fly   339 KLQVPLGRIKKAVTGGAIVSPQLIKDVRQVLNVEAVHSVYGLTETTAVIFQSLPGDSSDVVLNSV 403
            .....:..:...|..|:...|:||:.:...:|::.:...||.||.:.|.|...|.|:.:....||
Human   394 FSSYDISTMCGGVIAGSPAPPELIRAIINKINMKDLVVAYGTTENSPVTFAHFPEDTVEQKAESV 458

  Fly   404 GHLTDHIEAKVVDAE-GRCVPFGQPGELCVRGYTTMLGYHDDEEKTKETIGNDRWLRTGDQFVLE 467
            |.:..|.||::::.| |.......|||||:|||..||||..:.:||:|.:..|:|..|||...:.
Human   459 GRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMN 523

  Fly   468 ANGYGRIVGRLKEMLIRGGENIFPKEIEDFLNAHPQVIEAHVIGVPDERLGEEVCAYVRLEEGVD 532
            ..|:.:||||.|:|:|||||||:|.|:|||.:.||:|.|..|:||.|:|:|||:||.:||::|.:
Human   524 EQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEE 588

  Fly   533 PASFTAETLKAYAKGKLAHFKVPRYVIPIDAFPKTTSGKIQKFKLVE 579
            .   |.|.:||:.|||::|||:|:|::.:..:|.|.|||||||||.|
Human   589 T---TVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLRE 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	222/547 (41%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	146/353 (41%)
ACSF2	NP_001275897.1	PRK08315	82..640	CDD:236236	225/559 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159345
Domainoid	1	1.000	305	1.000	Domainoid score	I1375
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23519
Inparanoid	1	1.050	429	1.000	Inparanoid score	I1735
Isobase	1	0.950	-	0.815465	Normalized mean entropy	S2257
OMA	1	1.010	-	-		QHG62430
OrthoDB	1	1.010	-	-		D355104at33208
OrthoFinder	1	1.000	-	-		FOG0004397
OrthoInspector	1	1.000	-	-		oto90904
orthoMCL	1	0.900	-	-		OOG6_100107
Panther	1	1.100	-	-	LDO	PTHR43201
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R434
SonicParanoid	1	1.000	-	-		X154
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750