Protein Alignment CG12512 and AACS

DIOPT Version :9

• Sequence 1: NP_608924.1
• Gene: CG12512 / 33766
• FlyBaseID: FBgn0031703
• Length: 593
• Species: Drosophila melanogaster
• Sequence 2: NP_076417.2
• Gene: AACS / 65985
• HGNCID: 21298
• Length: 672
• Species: Homo sapiens
• Alignment Length: 608
• Identity: 136/608 - (22%)
• Similarity: 234/608 - (38%)
• Gaps: 143/608 - (23%)

  Fly    62 DVEAIVSCHEGK----RYSFKSLLQEADALAAGFRKLGLQPGDAVGLWAPNYLHWYLGMMGAARA 122
            |..|:....|||    :.:|:.|.||....||..||:|::.||.|..:.||..|....|:.||..
Human   112 DRVALYIAREGKEEIVKVTFEELRQEVALFAAAMRKMGVKKGDRVVGYLPNSEHAVEAMLAAASI 176

  Fly   123 GLTSVGLNPAYQGPEIAYCLNKVNVKAIIAPETF----KTQNYYEILRDICPEISDADTGKIRSE 183
            |......:|.:....:....:::..|.|.:.|..    |..|:.|.|:.:.             :
Human   177 GAIWSSTSPDFGVNGVLDRFSQIQPKLIFSVEAVVYNGKEHNHMEKLQQVV-------------K 228

  Fly   184 KFPHLRSVI----IDSNDS-----LKGALRFDDFLDLASKSEREEVAKMQKSILPES-ACNIQFT 238
            ..|.|:.|:    :.|.::     :..::..||||   :....|:..:::...||.| ...|.|:
Human   229 GLPDLKKVVVIPYVSSRENIDLSKIPNSVFLDDFL---ATGTSEQAPQLEFEQLPFSHPLFIMFS 290

  Fly   239 SGTTGNPKAACLTH-------HNFVNNGIHVGNRNELEGERICVQVPMFHAFGVIISIMAALTKG 296
            |||||.||  |:.|       .:...:.:| ||....: ..:|.....:..:..::|::|.   |
Human   291 SGTTGAPK--CMVHSAGGTLIQHLKEHLLH-GNMTSSD-ILLCYTTVGWMMWNWMVSLLAT---G 348

  Fly   297 ATMVLPAAGFSPKDSLQAIVNEKCSVIHGTPTMYVDLVNT---------QKKLQVPLGRIKKAVT 352
            |.|||...                |.:..||.:..|||:.         .|.|.|...:..|.|.
Human   349 AAMVLYDG----------------SPLVPTPNVLWDLVDRIGITVLVTGAKWLSVLEEKAMKPVE 397

  Fly   353 GGAIVSPQLIKDVRQVLNVEAVHSVYGLTETTAVIFQSLPGDSSDVVLNSVGH------LTDHIE 411
            ..::.....|......|..::...||...: ::::..|:.| .:|::...:||      ....|:
Human   398 THSLQMLHTILSTGSPLKAQSYEYVYRCIK-SSILLGSISG-GTDIISCFMGHNFSLPVYKGEIQ 460

  Fly   412 AK----VVDA---EGRCVPFGQPGEL-CVRGYTTMLGYHDDEEKTKETIGNDR-----------W 457
            |:    .|:|   ||:.| :|:.||| |.:.......:..::|.     ||..           |
Human   461 ARNLGMAVEAWNEEGKAV-WGESGELVCTKPIPCQPTHFWNDEN-----GNKYRKAYFSKFPGIW 519

  Fly   458 L---------RTGDQFVLEANGYGRIVGRLKEMLIRGGENIFPKEIEDFLNAHPQVIEAHVIGVP 513
            .         :||...:|     ||..|.|....:|.|.:    ||.:.:.:..:|.::..:...
Human   520 AHGDYCRINPKTGGIVML-----GRSDGTLNPNGVRFGSS----EIYNIVESFEEVEDSLCVPQY 575

  Fly   514 DERLGEEVCAYVRLEEGVDPASFTAETLK----AYAKGKLAHFKVPRYVIPIDAFPKTTSGK--- 571
            ::...|.|..::::..|   .:|..:.:|    |...| |:...||..::.....|.|.:||
Human   576 NKYREERVILFLKMASG---HAFQPDLVKRIRDAIRMG-LSARHVPSLILETKGIPYTLNGKKVE 636

  Fly   572 -----IQKFKLVE---AFKAKET 586
                 |...|.||   ||...||
Human   637 VAVKQIIAGKAVEQGGAFSNPET 659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	136/608 (22%)
		FACL_like_2	229..577	CDD:213284	87/410 (21%)
AACS	NP_076417.2	ac_ac_CoA_syn	16..670	CDD:273507	136/608 (22%)
		AACS	40..663	CDD:213308	136/608 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910