DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12512 and Acsf2

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001030123.1	Gene:	Acsf2 / 619561	RGDID:	1562656	Length:	615	Species:	Rattus norvegicus

Alignment Length:	609	Identity:	250/609 - (41%)
Similarity:	361/609 - (59%)	Gaps:	48/609 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NSKLQTISRYMLRQKCAFNS-MRSISTSMP----SLI-----SHKHHIGKDPLVYRTIGQQLELS 56
            |||||.:.        ||:| |...:..:|    |.|     ||        ||.:|:|:.|:.:
  Rat    33 NSKLQGVR--------AFSSGMVDCTNPLPIGGLSYIQGHTDSH--------LVNKTVGECLDAT 81

  Fly    57 ASNFGDVEAIVSCHEGKRYSFKSLLQEADALAAGFRKLGLQPGDAVGLWAPNYLHWYLGMMGAAR 121
            |..|.:.||:|..||..|.:|..|.:|.|..|:|...:||:.||.:|:|.||...|.|..:..|:
  Rat    82 AQRFPNREALVIIHENIRLNFAQLKEEVDRAASGLLSIGLRKGDRLGMWGPNSYAWVLIQLATAQ 146

  Fly   122 AGLTSVGLNPAYQGPEIAYCLNKVNVKAIIAPETFKTQNYYEILRDICPEISDADTGKIRSEKFP 186
            ||:..|.:|||||..|:.|.|.||..|.|:.|:.||||.||.||:.:|||:..|..|.::||:.|
  Rat   147 AGIILVSVNPAYQASELEYVLRKVGCKGIVFPKQFKTQQYYNILKQVCPELEKAQPGALKSERLP 211

  Fly   187 HLRSVI-IDSNDSLKGALRFDDFLDLASKSEREEVAKMQKSILPESAC----NIQFTSGTTGNPK 246
            .|.:|| :|:  .|.|.|..|:.:....|.:.....:..:..|   :|    |||||||||||||
  Rat   212 DLTTVISVDA--PLPGTLLLDEVVAAGGKEQNLAQLRYHQGFL---SCYDPINIQFTSGTTGNPK 271

  Fly   247 AACLTHHNFVNNGIHVGNRNEL-----EGERICVQVPMFHAFGVIISIMAALTKGATMVLPAAGF 306
            .|.|:|||.|||...:|.|.::     |..|:.:..|::|..|.:...|.::..|||::|.:..|
  Rat   272 GATLSHHNIVNNSNLIGQRLKMPAKTAEELRMVLPCPLYHCLGSVGGTMVSVVHGATLLLSSPSF 336

  Fly   307 SPKDSLQAIVNEKCSVIHGTPTMYVDLVNTQKKLQVPLGRIKKAVTGGAIVSPQLIKDVRQVLNV 371
            :.|.:|:||..||.::::|||||:||::|...........|:..|..|::..|:||:.:...:|:
  Rat   337 NGKKALEAISREKGTLLYGTPTMFVDILNQPDFSSYDFTTIRGGVIAGSLAPPELIRAIISKMNM 401

  Fly   372 EAVHSVYGLTETTAVIFQSLPGDSSDVVLNSVGHLTDHIEAKVVDAE-GRCVPFGQPGELCVRGY 435
            :.:..|||.||.:.|.|.:.|.|:.:....|||.:..|.||::|:.| |.......|||||:|||
  Rat   402 KELVVVYGTTENSPVTFMNFPEDTLEQKAGSVGRIMPHTEAQIVNMETGELTKLNMPGELCIRGY 466

  Fly   436 TTMLGYHDDEEKTKETIGNDRWLRTGDQFVLEANGYGRIVGRLKEMLIRGGENIFPKEIEDFLNA 500
            ..|.||..:.:||.||:|.|||.||||...::..|:.|||||.|:|:|||||||:|.|:|||.:.
  Rat   467 CVMQGYWGEPQKTFETVGQDRWYRTGDIASMDEQGFCRIVGRSKDMIIRGGENIYPAELEDFFHK 531

  Fly   501 HPQVIEAHVIGVPDERLGEEVCAYVRLEEGVDPASFTAETLKAYAKGKLAHFKVPRYVIPIDAFP 565
            ||||.||.|:||.|:|:|||:||.:||:.|   .:.|.|.:||:.|||::|||:|||::.::.:|
  Rat   532 HPQVQEAQVVGVKDDRMGEEICACIRLKSG---ETTTEEEIKAFCKGKISHFKIPRYIVFVEGYP 593

  Fly   566 KTTSGKIQKFKLVEAFKAKETELK 589
            .|.|||||||||.|..   |..||
  Rat   594 LTVSGKIQKFKLREQM---EQHLK 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	236/558 (42%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	158/357 (44%)
Acsf2	NP_001030123.1	PRK08315	57..615	CDD:236236	240/577 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353371
Domainoid	1	1.000	329	1.000	Domainoid score	I1128
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23519
Inparanoid	1	1.050	455	1.000	Inparanoid score	I1543
OMA	1	1.010	-	-		QHG62430
OrthoDB	1	1.010	-	-		D355104at33208
OrthoFinder	1	1.000	-	-		FOG0004397
OrthoInspector	1	1.000	-	-		oto97999
orthoMCL	1	0.900	-	-		OOG6_100107
Panther	1	1.100	-	-	LDO	PTHR43201
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X154
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770