DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12512 and DIP2B

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_775873.2	Gene:	DIP2B / 57609	HGNCID:	29284	Length:	1576	Species:	Homo sapiens

Alignment Length:	628	Identity:	115/628 - (18%)
Similarity:	209/628 - (33%)	Gaps:	175/628 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 GDVEAIVSCHEGKRYSFKSLLQEADALAAGFRKLG-LQPGDAVGLWAPNYLHWYLGMMGAARAGL 124
            |......||.:        |.:.|:.:|:.....| |..||.|.|..|..:.......|...||.
Human  1015 GTTVCTASCLQ--------LHKRAERIASVLGDKGHLNAGDNVVLLYPPGIELIAAFYGCLYAGC 1071

  Fly   125 TSVGLNPAYQG------PEIAYCLNKVNVKAIIAPETFKTQNYYEILRDICPEISDADTGKIRSE 183
            ..|.:.|.:..      |.:...::......|:..:|.     ..:||      |......:..:
Human  1072 IPVTVRPPHAQNLTATLPTVRMIVDVSKAACILTSQTL-----MRLLR------SREAAAAVDVK 1125

  Fly   184 KFPHLRSVIIDSNDSLKGALRFDDFLDLASKSEREEVAKMQKSILPESACNIQFTSGTTGNPKAA 248
            .:|    .|||::|                 ..|:.:.::.|...||....:.|:..|||.....
Human  1126 TWP----TIIDTDD-----------------LPRKRLPQLYKPPTPEMLAYLDFSVSTTGMLTGV 1169

  Fly   249 CLTHH--NFVNNGIHVGNRNELEGER-ICVQVPMFHAFGVIISIMAALTKGATMVL--------- 301
            .::|.  |.:...|.:  :.||...| |.:.:..:...|..:..:.::..|...||
Human  1170 KMSHSAVNALCRAIKL--QCELYSSRQIAICLDPYCGLGFALWCLCSVYSGHQSVLIPPMELENN 1232

  Fly   302 ------PAAGFSPKDSLQAI-VNEKCSVIHGTPTMYVDLVNTQKKLQVPLGRIKKAVTGGAIVSP 359
                  ....:..:|:..:. |.|.|:...|.   .|:::.|:   .:.|..::..|    :|:.
Human  1233 LFLWLSTVNQYKIRDTFCSYSVMELCTKGLGN---QVEVLKTR---GINLSCVRTCV----VVAE 1287

  Fly   360 Q------------LIKDVRQVLNVEAVHSVYGLTETTAVIFQSLPGDS----------------- 395
            :            |.||:.  |:..||.:.:|.....|:..|...|..
Human  1288 ERPRVALQQSFSKLFKDIG--LSPRAVSTTFGSRVNVAICLQGTSGPDPTTVYVDLKSLRHDRVR 1350

  Fly   396 -------SDVVLNSVGHLTDHIEAKVVDAEGRCVPFGQP--GELCVRGYTTMLGYHD-------- 443
                   ..::|:..|.:...::..:|:.|.: .|.|..  ||:.|....|..||:.
Human  1351 LVERGAPQSLLLSESGKILPGVKVVIVNPETK-GPVGDSHLGEIWVNSPHTASGYYTIYDSETLQ 1414

  Fly   444 -DEEKTKETIGN---DRWLRTGDQFVLEANGYGR----------------IVGRLKEMLIRGGEN 488
             |...|:.:.|:   ..|.|||      ..|:.|                :||.|.|.|...|..
Human  1415 ADHFNTRLSFGDAAQTLWARTG------YLGFVRRTELTAATGERHDALYVVGALDETLELRGLR 1473

  Fly   489 IFPKEIEDFLN-AHPQVIE------AHVIGVPDERLGEEVCAYVRLEEGVDPASFTAETLKAYAK 546
            ..|.:||..:: .|..:.|      .:::.|..|..|.|       :|.:|........:..
Human  1474 YHPIDIETSVSRIHRSIAECAVFTWTNLLVVVVELCGSE-------QEALDLVPLVTNVVLE--- 1528

  Fly   547 GKLAHFKVPRYVIPID--AFPKTTSGKIQKFKLVEAFKAKETE 587
               .|:.:...|:.:|  ..|..:.|:.|:..|.::|.|.:.:
Human  1529 ---EHYLIVGVVVVVDPGVIPINSRGEKQRMHLRDSFLADQLD 1568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	115/628 (18%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	81/441 (18%)
DIP2B	NP_775873.2	DMAP_binding	14..131	CDD:283995
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..167
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..201
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	217..246
		CaiC	336..912	CDD:223395
		AFD_class_I	360..924	CDD:302604
		AMP-binding	995..1470	CDD:278902	94/515 (18%)
		AFD_class_I	1012..1565	CDD:302604	114/623 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900