DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12512 and AgaP_AGAP003483

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	XP_001688203.2	Gene:	AgaP_AGAP003483 / 5667416	VectorBaseID:	AGAP003483	Length:	540	Species:	Anopheles gambiae

Alignment Length:	556	Identity:	163/556 - (29%)
Similarity:	246/556 - (44%)	Gaps:	74/556 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 LELSASNFGDV-----------EAIVSCHEGKRYSFKSLLQEADALAAGFRKLGLQPGDAVGLWA 106
            |.|.|.:.|.:           .|:|....|:.||::.:||.|..|||......:|.||.|.:.|
Mosquito    22 LTLGAHSLGQLFLKVLQKTPHSVALVDGVTGREYSYQEVLQSALQLAAYLHDHNIQRGDVVAIVA 86

  Fly   107 PNYLHWYLGMMGAARAGLTSVGLNPAYQGPEIAYCLNKVNVKAIIAPETFKTQNYYEILRDICPE 171
            .|...:.:.::.....|.|....||:|...|:.:.||....|.:.
Mosquito    87 ENRYEYPVTVIALFLVGATVALFNPSYTTRELVHALNVARPKLVF-------------------- 131

  Fly   172 ISDADTGKI----RSEKFPHLRSVIIDSNDSLKGALRFDDFLDLASKSEREEVAKMQ-KSI-LPE 230
            :|....|.:    ::.|.|.|..:   |.|:|:....|...|..:||  |..||.:| .|: :.|
Mosquito   132 VSSLARGSLLKASQTVKQPLLNVI---SYDALERGTSFAHCLQRSSK--RFTVASIQPMSVEIAE 191

  Fly   231 SACNIQFTSGTTGNPKAACLTHHNFVNNGIHVGNRNELE-GERICVQ---VPMFHAFGVIISIMA 291
            ....|..:|||||.||...:||.|.:....:|  |:.|: |..:...   :|.||..|. ||:::
Mosquito   192 EVAIIVMSSGTTGLPKGVLITHRNVMATMANV--RDALDKGLSLHCSLDVLPWFHVAGG-ISMLS 253

  Fly   292 ALTKGATMV-LPAAGFSPKDSLQAIVNEKCSVIHGTPTMYVDLVNTQKKLQVPLGRIKKAVTGGA 355
            .|....|:| ||.  |.|:..|:.|...:.|.::..|.:.|.|......|:..|..::....|.|
Mosquito   254 WLGANLTVVYLPR--FEPRTYLRCIERYRPSFLNMVPPIVVFLAKHPAVLEYDLTSVQTIACGAA 316

  Fly   356 IVSPQLIKDVRQVLNVE----AVHSVYGLTETT-AVIFQSLPGDSSDVVLNSVGHLTDHIEAKVV 415
            .:|    ::|.|::|..    .:...||::||| |:.|.    |...:...|:|.:......|||
Mosquito   317 PLS----REVEQLINERLPGIRIRQGYGMSETTQAITFY----DRDTLKPGSIGTVRAGQMGKVV 373

  Fly   416 DAE-GRCVPFGQPGELCVRGYTTMLGYHDDEEKTKETIGNDRWLRTGDQFVLEANGYGRIVGRLK 479
            |.| ||.:...|.||||.:|...|.||...|    ..|..|.||.|||....:::|...||.|||
Mosquito   374 DVETGRALGPNQQGELCFKGSLIMKGYIGAE----RVIDADGWLHTGDIGYYDSDGDFFIVDRLK 434

  Fly   480 EMLIRGGENIFPKEIEDFLNAHPQVIEAHVIGVPDERLGEEVCAYVRLEEGVDPASFTAETLKAY 544
            |::......:.|.|:|..|..:|.|.:..|:|..|||.||...|:|...||:   ..|.|.|..|
Mosquito   435 ELIKYKAFQVPPAELEAVLLTNPGVKDCAVVGKADERAGELPLAFVVPTEGI---PVTEEQLIQY 496

  Fly   545 AKGKLAHFKVPRYVIP-IDAFPKTTSGKIQKFKLVE 579
            ...::::.|..|..:. ::..|||.||||.:..|.|
Mosquito   497 VDERVSNEKRLRGGVRFVEEIPKTASGKILRRTLRE 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	163/556 (29%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	114/359 (32%)
AgaP_AGAP003483	XP_001688203.2	PLN02246	37..532	CDD:215137	158/539 (29%)
AgaP_AGAP003483	XP_001688203.2	AFD_class_I	45..526	CDD:302604	156/525 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X154
TreeFam	0	0.000	Not matched by this tool.
	3	2.810