DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12512 and e

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_524431.2	Gene:	e / 42521	FlyBaseID:	FBgn0000527	Length:	879	Species:	Drosophila melanogaster

Alignment Length:	598	Identity:	126/598 - (21%)
Similarity:	222/598 - (37%)	Gaps:	132/598 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 HIGKDPLVYR--TIGQQLELSASNFGDV--------EAIVSCHEGKRYSFKSLLQEADALAAGFR 92
            |..|..|:|:  |.||.:..|.|::..:        ..:|:...|:   |.....:.|.:.|
  Fly    33 HADKVALIYQPSTTGQGMAPSQSSYRQMNERANRAARLLVAETHGR---FLQPNSDGDFIVA--- 91

  Fly    93 KLGLQPGDAVGLWAPNYLHWYLGMMGAARAGLTSVGLNPAYQGPEIAYCLNKVNVKAIIAPETFK 157
             :.:||.:  ||.......|        :||...:.::|::..       |:::...:.|..|.
  Fly    92 -VCMQPSE--GLVTTLLAIW--------KAGGAYLPIDPSFPA-------NRIHHILLEAKPTL- 137

  Fly   158 TQNYYEILRDICPEISDADTGKIRS----------EKFPHLRSVIIDSNDSLKGALRFDDFLDLA 212
                  ::||     .|.|.|:.:.          .|...|....:.|.:.|:|.   :|.:.:
  Fly   138 ------VIRD-----DDIDAGRFQGTPTLSTTELYAKSLQLAGSNLLSEEMLRGG---NDHIAI- 187

  Fly   213 SKSEREEVAKMQKSILPESACNIQFTSGTTGNPKAACLTHHNFVNNGIHVGNRNELE-------- 269
                                  :.:|||:||.||...|.|.:.:       ||.:.:
  Fly   188 ----------------------VLYTSGSTGVPKGVRLPHESIL-------NRLQWQWATFPYTA 223

  Fly   270 GERICVQVPMFHAFGVIISIMAALTKG-ATMVLPAAGFSPKDSLQAIVNE-KCSVIHGTPTMYVD 332
            .|.:.|..........|..:...|..| |.:|:|.|.......|.|::.. |...:...||:...
  Fly   224 NEAVSVFKTALTFVDSIAELWGPLMCGLAILVVPKAVTKDPQRLVALLERYKIRRLVLVPTLLRS 288

  Fly   333 LVNTQK-----KLQVPLGRIKKAVTGGAIVSPQLIKDVRQVLNVEAVHSVYGLTETTAVIFQSLP 392
            |:...|     ..|..|..::..|..|..:|..|........: |.||.:|....:|.|:
  Fly   289 LLMYLKMEGGGAAQKLLYNLQIWVCSGEPLSVSLASSFFDYFD-EGVHRLYNFYGSTEVL----- 347

  Fly   393 GDSSDVVLNSVGHLT--DHIEAKV---------VDAEGRCVPFGQPGELCVRGYTTMLGY---HD 443
            ||.:.....|...|:  |::...:         :||:.|.|..|:.||:...|.....||   .|
  Fly   348 GDVTYFACESKKQLSLYDNVPIGIPLSNTVVYLLDADYRPVKNGEIGEIFASGLNLAAGYVNGRD 412

  Fly   444 DEEKTKETIGND----RWLRTGDQFVLEANGYGRIVGRLKEMLIRGGENIFPKEIEDFLNAHPQV 504
            .|...:..:..:    |..||||...|: ||.....||....:...|..:...|:|..:...|.|
  Fly   413 PERFLENPLAVEKKYARLYRTGDYGSLK-NGSIMYEGRTDSQVKIRGHRVDLSEVEKNVAELPLV 476

  Fly   505 IEAHVIGVPDERLGEEVCAYVRLEEGVDPASFTAETLKAYAKGKLAHFKVPRYVIPIDAFPKTTS 569
            .:|.|:.....::.:.:.|:|:|.:  |....|...::|..|.|||.:..|:.|| ::..|...:
  Fly   477 DKAIVLCYHAGQVDQAILAFVKLRD--DAPMVTEMQMEARLKDKLADYMTPQVVI-LEHVPLLVN 538

  Fly   570 GKIQKFKLVEAFK 582
            ||:.:..|::.::
  Fly   539 GKVDRQALLKTYE 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	124/593 (21%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	89/380 (23%)
e	NP_524431.2	A_NRPS	35..546	CDD:213296	124/589 (21%)
		AA-adenyl-dom	56..481	CDD:273779	99/500 (20%)
		PP-binding	580..644	CDD:278949
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910