DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12512 and CG6300

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_650828.1	Gene:	CG6300 / 42351	FlyBaseID:	FBgn0038730	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	560	Identity:	128/560 - (22%)
Similarity:	229/560 - (40%)	Gaps:	73/560 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 TIGQQLELSASNFGDVEAIVSCHEGKRYSFKSLLQEADALAAGFRKLGLQPGDAVGLWAPNYLHW 112
            :||:.:.........:.|.:|..||...:...||..|..||:..|.|||...|.||:...|..|
  Fly    30 SIGEIIFHEMRRHPQLTAQISATEGTVLTRGELLANAMRLASYMRSLGLLQSDIVGIIGRNTTH- 93

  Fly   113 YLGMMGAARA----GLTSVGLNPAYQGPEIAYCLNKVNVKAIIAPETFKTQNYYEILRDICPEIS 173
               |:..|.|    |:....||..|....|                    :..|::.|   |.|.
  Fly    94 ---MLAVAYACFFNGIAFHSLNITYDRDTI--------------------EKIYKVTR---PSII 132

  Fly   174 DADTGKIRSEKFPHLRSV-------IIDSNDSLKGALRFDDFLDLASKSEREEVAKMQKSILPES 231
            ..|     .::|..:||.       |:...:....:::.|:.: .....|..:.||::|.  .:.
  Fly   133 FCD-----GDEFEKVRSATAELDVKIVTMRNHPLDSIKIDEVV-ATPIEENFQPAKLEKG--NDQ 189

  Fly   232 ACNIQFTSGTTGNPKAACLTHHNFVNNGIHV--GNRNELEGERICVQVPMFHAFGVIISIMAALT 294
            ...|..:|||||.|||..:|      |..|:  ||.:....:   ||. ..:....|..::..:|
  Fly   190 TLAILCSSGTTGTPKAVTIT------NSRHILAGNYHLTTAD---VQY-SHNTLDWITGLLTTIT 244

  Fly   295 KG---ATMVLPAAGFSPKDSLQAIVNEKCSVIHGTPTMYVDLVNTQKKLQVPLGRIKKAVTGGAI 356
            .|   .|.::....|.|..:|:.|...|.:.....|:....::|........:..::..:.||:.
  Fly   245 SGVFSTTRIIADNAFDPAFALRIIEEYKVTWTIQPPSSMALMINCPDFETCDMSSLRCYMFGGSR 309

  Fly   357 VSPQLIKDVRQVLNVEAVHSVYGLTETTAVIFQSLPGDSSDVVLNSVGHLTDHIEAKVVDAEGRC 421
            .:.::.|.:|..|:.:.:..|||.||..|:...:...|..   ..|||.|.:.::.|:::.:|..
  Fly   310 AALEVQKGIRSRLSHDCLQFVYGFTELGAMATINCHFDEK---TGSVGQLVNGLKMKIINDDGES 371

  Fly   422 VPFGQPGELCVRGYTTMLGYHDDEEKTKETIGNDRWLRTGDQFVLEANGYGRIVGRLKEMLIRGG 486
            :...:.||:|:.......||:.:|.:|:....:..|..:||...::.:|:..|:.|.||||....
  Fly   372 LGPDEIGEVCIMNNQHWSGYYGNEVETRNMRDSLGWYHSGDLGYMDRDGFLYIMDRKKEMLKYQN 436

  Fly   487 ENIFPKEIEDFLNAHPQVIEAHVIGVPDERLGEEVCAYVRLEEGVDPASFTAETLKAYAKGKL-- 549
            ...:|.:||..::..|||.|..|.|:.....|:|..|.|..:.|   :...|:.:..|.:.:.
  Fly   437 IMYYPNDIESVISEMPQVAEVCVFGIWSNIFGDEAAAAVVKKLG---SELEAQDVVDYVRSRTDS 498

  Fly   550 AHFKVPRYVIPIDAFPKTTSGKIQKFKLVEAFKAKETELK 589
            .:.::....:.:|...::.:||..:.    |.||....||
  Fly   499 KYKQLNGGAVIVDDLQRSANGKTNRM----ANKAYFLHLK 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	128/560 (23%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	81/354 (23%)
CG6300	NP_650828.1	CaiC	26..523	CDD:223395	123/543 (23%)
CG6300	NP_650828.1	AFD_class_I	47..522	CDD:302604	121/525 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810