DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12512 and CG4830

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_650160.1	Gene:	CG4830 / 41477	FlyBaseID:	FBgn0037996	Length:	534	Species:	Drosophila melanogaster

Alignment Length:	578	Identity:	133/578 - (23%)
Similarity:	230/578 - (39%)	Gaps:	77/578 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 MLRQKCAFNSMRSISTSMPSLISHKHHIGKDPLVYRT-IGQQLELSASNFGDVEAIVSCHEGKRY 75
            |.:..|::::...|...:|.         .:|....| :|:.:..:..|:......:|..||...
  Fly     1 MSKLPCSYDAENKIWKGIPQ---------NNPFKPETSLGRIIFKNMRNWPKNVCQISDSEGVEV 56

  Fly    76 SFKSLLQEADALAAGFRKLGLQPGDAVGLWAPNYLHWYLGMMGAARA----GLTSVGLNPAYQGP 136
            :|...|..|..:|...:..||...|.:|:.|.|..:    :|..|.|    |......||..:..
  Fly    57 TFGQALTWAIRIAQQLKSRGLDHKDIIGISARNTTY----IMPTAVACFFHGTPFQSANPILEES 117

  Fly   137 EIAYCLNKVNVKAIIAPETFKTQNYYEILRDICPEISDADTGKIRSEKFPHLRSVIIDSNDSLKG 201
            .:.:..|....|.|     |...::|:.|.        :.|...:.|        ||.:..:..|
  Fly   118 TLKHLYNISKPKII-----FTDADHYDKLY--------SATSAFKPE--------IILTTGTKDG 161

  Fly   202 ALRFDDFLDLASKSEREEVAKMQKSILPESACNIQFTSGTTGNPKAACLTHHNFVNNGIHVGNRN 266
            .|...|.|.........:...:::.  |.....|..:|||||.|||.|:::.......:.|...
  Fly   162 VLSIQDLLAPTKTEFFYQPTPLKEG--PSQTVAILTSSGTTGMPKAVCISNDILTQETVFVNGY- 223

  Fly   267 ELEGERICVQVPMFHAFGVIISIMAALTKGATMVLPAAGFS--------PKDSL--QAIVNEKCS 321
                :.|.:...:....|:..:|.:.: .|.|.::.:..|:        .|.|:  ..|..|.|.
  Fly   224 ----DTIFISASLDWITGLWATIFSTV-NGCTRIISSKPFAADYFVYLVSKYSITYALIPPEHCC 283

  Fly   322 VIHGTPTMYVDLVNTQKKLQVPLGRIKKAVTGGAIVSPQLIKDVRQVLNVEAVHSVYGLTETTAV 386
            .:...||.      |.:|    ||.:.|...||..::...::.|:::.....::|.||:||...:
  Fly   284 SLLDCPTA------TPEK----LGSLTKLNFGGGRMTQATVERVKKLAPNGVLNSSYGMTEVGFI 338

  Fly   387 IFQSLPGDSSDVVLNSVGHLTDHIEAKVVDAEGRCVPFGQPGELCVRGYTTMLGYHDDEEKTKET 451
            :|     :...:.|.:.|:....|:.|:||.:|..:...|.||:.|....:..||..|.|.||..
  Fly   339 VF-----NHGHLKLTAAGNPLPGIQVKIVDDDGNQLGVNQTGEIIVHNGFSWNGYFADPEATKAM 398

  Fly   452 IGNDRWLRTGDQFVLEANGYGRIVGRLKEMLIRGGENIFPKEIEDFLNAHPQVIEAHVIGVPDER 516
            ...:.|..|||....:.:.|..:..|.||:|...|..::|.|:|..::..|:|....||||.||.
  Fly   399 QDEEGWFHTGDMGYFDEDDYLYMTDRKKEVLKWKGLQMWPAEVEAVIDELPEVKRVCVIGVYDET 463

  Fly   517 LGEEVCAYVRLEEGVDPASFTAETLKAYAKGKLAHF-KVPRYVIPI-DAFPKTTSGKI 572
            .|:...|.|..|   |.|:.||:.:..:...:|... |..|..:.. |..|:..:||:
  Fly   464 QGDVPGALVVRE---DNATLTAQQVIDHVAKRLPDIQKQLRAGVQFADEIPQNHNGKV 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	129/547 (24%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	92/356 (26%)
CG4830	NP_650160.1	CaiC	18..529	CDD:223395	130/561 (23%)
CG4830	NP_650160.1	AFD_class_I	46..518	CDD:302604	124/522 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810