DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12512 and CG9993

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_611518.1	Gene:	CG9993 / 37358	FlyBaseID:	FBgn0034553	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	577	Identity:	134/577 - (23%)
Similarity:	226/577 - (39%)	Gaps:	76/577 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 KHHIGKDPLVYRTIGQQLELSASNFGDVEAIVSCHEGKRYSFKSLLQEADALAAGFRKLGLQPGD 100
            |.:.|.|    .|:|:...:....:.|....|....|:..:...||:::..||..|::|.||.||
  Fly    19 KEYYGPD----MTLGEVALIILRLYSDKVMQVYDPTGEELTGSQLLEQSRRLAHAFQRLKLQRGD 79

  Fly   101 AVGLWAPNYLHWYLGMMGAARAGLTSVGLNPAYQGPEIAYCLNKVNVKAIIAPETFKTQNYYEIL 165
            .||:.|.|..:....::.|...|.....|:|.:.....||.......|.|     |...:.|:.|
  Fly    80 VVGISAKNTTYLTEVVIAALLNGTPINPLHPDFDAETTAYMFEITKPKVI-----FCDLDNYQTL 139

  Fly   166 RDICPEISDADTGKIRSEKFPHLRSVIIDSNDSLKGALRFDDFLDLASKSEREEVAKMQKSILPE 230
            ..:...:      |.::|        ||....:|.|.....|.|........|:.......:..:
  Fly   140 SAVKSSL------KFKTE--------IILLTGTLPGVRNIQDLLADGCTGYDEKTLFACPHLCGD 190

  Fly   231 SACNIQFTSGTTGNPKAACLTHHNFVNNGIHVGNRNELEGERICVQVPM-------------FHA 282
            ....|..:||.||.||....:|.:.:|:                .::|.             .:.
  Fly   191 DTAFIITSSGVTGLPKGVTRSHRSLLNS----------------AKIPQLFTSDTVLFCFSPLYW 239

  Fly   283 FGVIISIMAALTKGATMVLPAAGFSPKDSLQAIVNEKCSVIHGTPTMYVDLVNT--QKKLQVPLG 345
            ...|.:::|:|..|...::....||.......:...:.|.:...|.....|..:  :::|...:.
  Fly   240 ISCIFTLLASLVNGCRRIITNRPFSVAYFADLVERHQVSFVLTVPHHMALLAKSPERQELAAKMQ 304

  Fly   346 RIKKAVTGGAIVSPQLIKDVRQVLNVEAVHSVYGLTETTAVIFQSLPGDSSDV--VLNSVGHLTD 408
            .::..|..|:.|...:.:.:.::|.......:||||||        .|.|.:|  .|.|.|.|..
  Fly   305 CVQSFVCSGSKVPMGIWRQLYELLGANRFAVLYGLTET--------GGISKNVGGPLGSEGRLLR 361

  Fly   409 HIEAKVVDAEGRCVPFGQPGELCVRGYTTMLGYHDDEEKTKETIGND-RWLRTGDQFVLEANGYG 472
            :::.:|||..|:.:...|.|::.||......||:.:.::|:.|:..| :||.|||....:..|..
  Fly   362 NVQVRVVDPHGQSLGPNQTGQILVRLNLRWGGYYHNPQETQVTVTPDGKWLLTGDHGYFDDEGCL 426

  Fly   473 RIVGRLKEMLIRGGENIFPKEIEDFLNAHPQVIEAHVIGVPDE-RLGEEVCAYVRLEEGVDPASF 536
            ....|..::.......|:||:|||.:...|.|.|..|.|:||| ......||.||.|:     ..
  Fly   427 HFQSRDTDVFKYNHFPIYPKQIEDVILHLPGVHEVAVFGIPDEVSTNLTACAVVRNED-----EL 486

  Fly   537 TAETLKAYAKGKLAH-----FKVPRYVIPIDAFPKTTSGKIQKFKLVEAFKAKETEL 588
            .|:..:|..||.:|.     |.:...|..:|..|||.:.|:|:.|:........|.|
  Fly   487 GAQLTEADVKGVVAQHLSDAFHIRGGVFFVDNLPKTQNSKVQRRKIWSQLSEATTHL 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	131/570 (23%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	89/371 (24%)
CG9993	NP_611518.1	CaiC	21..532	CDD:223395	130/562 (23%)
CG9993	NP_611518.1	AFD_class_I	45..528	CDD:302604	124/530 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810