DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12512 and acs-2

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_506869.1	Gene:	acs-2 / 3565680	WormBaseID:	WBGene00009221	Length:	618	Species:	Caenorhabditis elegans

Alignment Length:	562	Identity:	204/562 - (36%)
Similarity:	308/562 - (54%)	Gaps:	20/562 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SHKHHIGKDPLVYRTIGQQLELSASNFGDVEAIVSCHEGKRYSFKSLLQEADALAAGFRKLGLQP 98
            |:.|.....||...|:||.|..:.....|.|..|......|.:::....:...:||....|||:.
Worm    46 SYIHGTSNIPLRNETLGQTLRNTTERVPDKEFCVFSKYPIRKTYEEFYHDVRQMAASLYTLGLEK 110

  Fly    99 GDAVGLWAPNYLHWYLGMMGAARAGLTSVGLNPAYQGPEIAYCLNKVNVKAIIAPETFKTQNYYE 163
            ||.||:|.|||..|.:.....|.||:..|.:||.|...|:.:.:.|..:|.:.||:..|..||..
Worm   111 GDRVGVWGPNYYEWVVLQYACAFAGVIQVNVNPHYLHEELRFVMRKTGMKVLFAPKRHKHSNYVH 175

  Fly   164 ILRDICPEI--SDADTGKIRSEKFPHLRSVIIDSND-SLKGALRFDDFLDLASKSEREEVAKMQK 225
            .:.:..||:  .....|.|:|...|.||.:::..:| .:.||..:.|.:..|..:||.::..|.:
Worm   176 TMLEAMPEMRRGQPGVGHIKSHDIPELRHIVLYGDDVPVHGAWVYSDLIHAAGSAERAKLEDMDR 240

  Fly   226 SILPESACNIQFTSGTTGNPKAACLTHHNFVNNGIHVGNRN--ELEGERICVQVPMFHAFGVIIS 288
            .:.|:...|:||||||||:||.|.|||....||....|.|.  :.|..|||:..|::|.||..:.
Worm   241 KLRPDEPVNMQFTSGTTGHPKGATLTHFGLNNNAYFAGIRLGWDREDHRICIPNPLYHCFGCAVG 305

  Fly   289 IMAALTKGATMVLPAAGFSPKDSLQAIVNEKCSVIHGTPTMYVDLVNTQKKLQVPLGRIKKAVTG 353
            ::.|:..|.|:|.|:..:...|..:||.||||:.:.|||||::|::.:....|..:..::..|.|
Worm   306 VINAVNHGQTVVFPSKSYHVPDIFEAIQNEKCTTMFGTPTMFIDVLKSPLMKQFDISSLRGGVIG 370

  Fly   354 GA----IVSPQLIKDVRQV-LNVEAVHSVYGLTETTAVIFQS-LPGDSSDVVLNSVGHLTDHIEA 412
            ||    .:..:::|::|.. .:|     :||.|||:.::..| |..|..:.: .|||.:..|.|.
Worm   371 GAPCPMALCEKMVKEMRMTDFSV-----IYGSTETSPLVTMSELHVDPFERI-KSVGSVMPHQEL 429

  Fly   413 KVVDAEGRCVPFGQPGELCVRGYTTMLGYHDDEEKTKETIGNDRWLRTGDQFVLEANGYGRIVGR 477
            .:||..|..||.|..|||..|||:|||||..|.:||...|..|||.::||...:..:|...||||
Worm   430 AIVDEFGVPVPTGAKGELWSRGYSTMLGYWADHDKTNLAITRDRWYKSGDTATMNEDGTINIVGR 494

  Fly   478 LKEMLIRGGENIFPKEIEDFLNAHPQVIEAHVIGVPDERLGEEVCAYVRLEEGVDPASFTAETLK 542
            .::|:::||||::|.|||.||:....|.:|||:||||:|.||.:||:|||.. .|....|||.:|
Worm   495 TRDMIVKGGENVYPTEIEQFLHKLDYVADAHVVGVPDDRYGENICAWVRLRV-EDEGKITAEHIK 558

  Fly   543 AYAKGKLAHFKVPRYVI--PIDAFPKTTSGKIQKFKLVEAFK 582
            ...|..:||:|||:||:  ....||.|.|||::||::.:..|
Worm   559 KACKRGMAHYKVPKYVLIKKESEFPLTISGKVKKFEIQKISK 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	202/553 (37%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	146/357 (41%)
acs-2	NP_506869.1	PRK08315	46..609	CDD:236236	204/562 (36%)
acs-2	NP_506869.1	FACL_like_2	244..595	CDD:213284	146/357 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	316	1.000	Domainoid score	I686
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23519
Inparanoid	1	1.050	434	1.000	Inparanoid score	I952
Isobase	1	0.950	-	0.815465	Normalized mean entropy	S2257
OMA	1	1.010	-	-		QHG62430
OrthoDB	1	1.010	-	-		D355104at33208
OrthoFinder	1	1.000	-	-		FOG0004397
OrthoInspector	1	1.000	-	-		otm14221
orthoMCL	1	0.900	-	-		OOG6_100107
Panther	1	1.100	-	-	O	PTHR43201
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X154
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.830