DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12512 and AgaP_AGAP008545

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	XP_557684.1	Gene:	AgaP_AGAP008545 / 3291745	VectorBaseID:	AGAP008545	Length:	548	Species:	Anopheles gambiae

Alignment Length:	540	Identity:	123/540 - (22%)
Similarity:	221/540 - (40%)	Gaps:	87/540 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 GKRYSFKSLLQEADALAAGFRKLGLQPGDAVGLWAPNYLHWYLGMMGAARAGLTSVGL--NPAYQ 134
            |:..::..........|....|:||:||:.|.|...|..:     :......|.::|:  ||
Mosquito    53 GRSLTYAEFRTRLIRFAQNLTKVGLRPGEVVVLANANSEN-----LAPLACALLTIGVPFNP--- 109

  Fly   135 GPEIAYCLNKVNVKAIIAPETFKTQNYYEILRDICPEI--SDADTGKIRSEKFPHLRSVIIDSND 197
                            :|| .|...:...:||...|::  :|||..::..:...|    .:...|
Mosquito   110 ----------------LAP-AFNEYDMENMLRTTKPKLVFADADNYEVVRKALEH----AVPRGD 153

  Fly   198 SLKGALRFDDFLDLASKSE--REEVAKMQKSILP------ESACNIQFTSGTTGNPKAACLTHHN 254
            :|.....|:...|....:|  .:|....:..:.|      ::...|..:|||:|..|...:||..
Mosquito   154 TLPPIYVFECTRDDVKHAEDFMKETGSEETFVAPYLGDSNKTVAAILCSSGTSGPHKGVQVTHAA 218

  Fly   255 FVNNGIHVGNRNELEGERICVQVPMFH--------AFGVIISIMAALTKGATMVLPAAGFSPKDS 311
            .    :|:..|.     |.....|..|        |.| ..|::.....|...::....||.:..
Mosquito   219 C----MHMTLRT-----RFFDATPSVHFNFSALHWATG-FASMLTPFFSGTIRLITRKSFSERQF 273

  Fly   312 LQAIVNEKCSVIHGTPTMYVDLVNTQKKLQ-VPLGRIKKAVTGGAIVSPQLIKDVRQVLNVEAVH 375
            |:|:...:...|. .||.|.:.|....:.: ..|..:|..:.||:.|..:|...:..:|......
Mosquito   274 LEAVEKYRVQAIF-LPTAYSNAVMAHPRTKTADLSSLKIWMVGGSHVPEELRDRIDALLRPTGGR 337

  Fly   376 SV--YGLTETTAV---IFQSLPGDSSDVVLNSVGHLTDHIEAKVVDAEGRCVPFGQPGELCVRGY 435
            ||  ||.:|..|.   |.:..||.:..::||::        .::||..|..:..|:.|||..:..
Mosquito   338 SVTTYGSSENGACAMDIPKRKPGATGPLMLNTM--------IRIVDENGNRLGVGKQGELLTKMS 394

  Fly   436 TTMLGYHDDEEKTKETIGNDRWLRTGDQFVLEANGYGRIVGRLKEMLIRGGENIFPKEIEDFLNA 500
            ....||:.:||.::..|.:|.:.||||...::..||..:|.|.|::....|..:.|.|:|..:.|
Mosquito   395 VEFGGYYGNEEASRNAIDSDGFFRTGDIGYIDEEGYLHVVDRKKDIFKYSGLQVVPTELEAIITA 459

  Fly   501 HPQVIEAHVIGVPDERLGEEVCAYV---RLEEGVDPASFTAETLKAYAKGKLAHFKVPR---YVI 559
            ...|.|..|:|:.:.:...:|.|.|   |.:..:|     |..:::...|:::.:|..|   :.:
Mosquito   460 IEGVQEVCVVGIRNTQNATDVPAAVIVRRRDSKLD-----ASQVRSIVDGQVSDYKRLRGGVHFL 519

  Fly   560 PIDAFPKTTSGKIQKFKLVE 579
            |  ..|||.:||:.:.|::|
Mosquito   520 P--ELPKTQTGKVMRRKVIE 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	123/540 (23%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	91/373 (24%)
AgaP_AGAP008545	XP_557684.1	CaiC	25..541	CDD:223395	123/540 (23%)
AgaP_AGAP008545	XP_557684.1	AFD_class_I	47..531	CDD:302604	121/532 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810