DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12512 and Acsf2

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_722502.1	Gene:	Acsf2 / 264895	MGIID:	2388287	Length:	615	Species:	Mus musculus

Alignment Length:	606	Identity:	247/606 - (40%)
Similarity:	364/606 - (60%)	Gaps:	42/606 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NSKLQTISRYMLRQKCAFNSMRSISTSMPSL--------ISHKHHIGKDPLVYRTIGQQLELSAS 58
            |||||              |:|::|:.|.:.        :|:........||..|:|:.|:.:|.
Mouse    33 NSKLQ--------------SVRALSSGMVNCTNPLPIGGLSYIQGHTDSHLVNTTVGECLDATAQ 83

  Fly    59 NFGDVEAIVSCHEGKRYSFKSLLQEADALAAGFRKLGLQPGDAVGLWAPNYLHWYLGMMGAARAG 123
            .|.|.||:|..||..|.:|..|.:|.|..|:|...:||:.||.:|:|.||...|.|..:..|:||
Mouse    84 RFPDREALVILHENIRLNFAQLKEEVDKAASGLLSIGLRKGDRLGMWGPNSYAWVLIQLATAQAG 148

  Fly   124 LTSVGLNPAYQGPEIAYCLNKVNVKAIIAPETFKTQNYYEILRDICPEISDADTGKIRSEKFPHL 188
            :..|.:|||||..|:.|.|.||..|.|:.|:.||||.||:||:.:|||:..|..|.::||:.|.|
Mouse   149 IILVSVNPAYQSSELEYVLRKVGCKGIVFPKQFKTQQYYDILKQVCPELEKAQPGALKSERLPDL 213

  Fly   189 RSVI-IDSNDSLKGALRFDDFLDLASKSEREEVAKM---QKSILPESACNIQFTSGTTGNPKAAC 249
            .:|| :|:  .|.|.|..||.  :|:..:.:.:|::   |:.:......|||||||||||||.|.
Mouse   214 TTVISVDA--PLPGTLLLDDI--VAAGGKEQNLAQLRYNQRFLSCYDPINIQFTSGTTGNPKGAT 274

  Fly   250 LTHHNFVNNGIHVGNRNEL-----EGERICVQVPMFHAFGVIISIMAALTKGATMVLPAAGFSPK 309
            |:|||.|||.:.:|.|.::     |..|:.:..|::|..|.:...|.::..|||::|.:..|:.|
Mouse   275 LSHHNIVNNSMLIGQRLKMPTKTAEELRLVLPSPLYHCLGSVGGTMVSMMHGATLLLSSPSFNGK 339

  Fly   310 DSLQAIVNEKCSVIHGTPTMYVDLVNTQKKLQVPLGRIKKAVTGGAIVSPQLIKDVRQVLNVEAV 374
            .:|:||..||.::::|||||:||::|...........|:..|..|:...|:||:.:...:|::.:
Mouse   340 KALEAISREKGTLLYGTPTMFVDILNQPDFSSYDFTSIRGGVIAGSPAPPELIRAIINKMNMKEL 404

  Fly   375 HSVYGLTETTAVIFQSLPGDSSDVVLNSVGHLTDHIEAKVVDAE-GRCVPFGQPGELCVRGYTTM 438
            ..|||.||.:.|.|.:.|.|:.:....|||.:..|.||::|:.| |.......||||.:|||..|
Mouse   405 VVVYGTTENSPVTFMNFPEDTLEQKAGSVGRIMPHTEAQIVNVETGELTNLNVPGELYIRGYCVM 469

  Fly   439 LGYHDDEEKTKETIGNDRWLRTGDQFVLEANGYGRIVGRLKEMLIRGGENIFPKEIEDFLNAHPQ 503
            .||..:.:||.||:|.|:|.||||..:::..|:.:||||.|:|:|||||||:|.|:|||...|||
Mouse   470 QGYWGEPQKTFETVGQDKWYRTGDIALMDEQGFCKIVGRSKDMIIRGGENIYPAELEDFFLKHPQ 534

  Fly   504 VIEAHVIGVPDERLGEEVCAYVRLEEGVDPASFTAETLKAYAKGKLAHFKVPRYVIPIDAFPKTT 568
            |.||.|:||.|||:|||:||.:||:.|   .:.|||.:||:.|||::|||:|||::.::.:|.|.
Mouse   535 VQEAQVVGVKDERMGEEICACIRLKSG---ETTTAEEIKAFCKGKISHFKIPRYIVFVEGYPLTI 596

  Fly   569 SGKIQKFKLVEAFKAKETELK 589
            |||||||||.|..   |..||
Mouse   597 SGKIQKFKLREQM---EQHLK 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	237/557 (43%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	156/353 (44%)
Acsf2	NP_722502.1	PRK08315	57..615	CDD:236236	238/568 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849715
Domainoid	1	1.000	327	1.000	Domainoid score	I1176
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23519
Inparanoid	1	1.050	453	1.000	Inparanoid score	I1592
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62430
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004397
OrthoInspector	1	1.000	-	-		oto94486
orthoMCL	1	0.900	-	-		OOG6_100107
Panther	1	1.100	-	-	LDO	PTHR43201
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R434
SonicParanoid	1	1.000	-	-		X154
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790