DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12512 and Acsf3

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_659181.2	Gene:	Acsf3 / 257633	MGIID:	2182591	Length:	583	Species:	Mus musculus

Alignment Length:	597	Identity:	153/597 - (25%)
Similarity:	246/597 - (41%)	Gaps:	120/597 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 HHIGKDPLVYRTIGQQLELSASNFGDVEAIVSCHEGKRYSFKSLLQEADALAAGFRKL-GLQPGD 100
            |..|..|:..|.:.         |||..|::..:  ..::::.|...:..||....:| |.:.||
Mouse    39 HTDGSVPVFIRALA---------FGDRIALIDKY--GHHTYRELYDRSLCLAQEICRLQGCKVGD 92

  Fly   101 ----AVGLWAPNYLHWYLGMMGAARAGLTSVGLNPAYQGPEIAYCLNKVNVKAIIAPETFKTQNY 161
                .|.....|.:.:.:....:..:|..:|.|...:...::.|.:.......::.     .|.|
Mouse    93 LQEERVSFLCSNDVSYVVAQWASWMSGGVAVPLYWKHPEAQLEYFIQDSRSSLVVV-----GQEY 152

  Fly   162 YEILRDICPEISDADTGKIRSEKFPHLRSVIIDSNDSLKGALRFDDFLDLASKSEREEVAKMQKS 226
            .|.|..:..        ::.....|...:|       ..||            :|:.....:::|
Mouse   153 LERLSPLAQ--------RLGVPLLPLTPAV-------YHGA------------TEKPTEQPVEES 190

  Fly   227 ILPESACNIQFTSGTTGNPKAACLTHHNF---VNNGIH--VGNRNELEGERICVQVPMFHAFGVI 286
            ...:....|.:||||||.||.|..||.|.   |...:|  ...:|::    |...:|:.|..||:
Mouse   191 GWRDRGAMIFYTSGTTGRPKGALSTHRNLAAVVTGLVHSWAWTKNDV----ILHVLPLHHVHGVV 251

  Fly   287 ISIMAALTKGATMV-LPAAGFSPKDSLQAIVNEKC---SVIHGTPTMYVDLVN------TQKKLQ 341
            ..::..|..|||.| ||.  ||.:...:..::.:.   :|....||:|..|::      ||..:|
Mouse   252 NKLLCPLWVGATCVMLPE--FSAQQVWEKFLSSEAPQITVFMAVPTVYSKLLDYYDKHFTQPHVQ 314

  Fly   342 -----VPLGRIKKAVTGGAIVSPQLIKDVRQVLNVEAVHSV---YGLTETTAVIFQSL-----PG 393
                 |...||:..|:|.|.:...|::..|....    |::   ||:||....:...|     ||
Mouse   315 DFVRAVCKERIRLMVSGSAALPVPLLEKWRSATG----HTLLERYGMTEIGMALSNPLTEARVPG 375

  Fly   394 DSSDVVLNSVGHLTDHIEAKVVD------------AEG-----RCVPFG---QPGELCVRGYTTM 438
                    |||.....:|.:::.            |||     :..| |   :.|||.|||.:..
Mouse   376 --------SVGTPLPGVEVRIISENPQKGSPYIIHAEGNERGTKVTP-GFEEKEGELLVRGPSVF 431

  Fly   439 LGYHDDEEKTKETIGNDRWLRTGDQFVLEANGYGRIVGRLKEMLIR-GGENIFPKEIEDFLNAHP 502
            ..|.|..|:||....:|.|.||||..|.:...|. |.||....:|: ||..:...|||..|.|||
Mouse   432 REYWDKPEETKSAFTSDGWFRTGDTAVFKDARYW-IRGRTSVDIIKTGGYKVSALEIERHLLAHP 495

  Fly   503 QVIEAHVIGVPDERLGEEVCAYVRLEEGVDPASFTAETLKAYAKGKLAHFKVPRYVIPIDAFPKT 567
            .:.:..||||||...|:.|.|.|.|:||   .|.:...||.:|:|.||.:.||..::.::..|:.
Mouse   496 SITDVAVIGVPDMTWGQRVTAVVALQEG---HSLSHGDLKEWARGVLAPYAVPSELLLVEEIPRN 557

  Fly   568 TSGKIQKFKLVE 579
            ..||:.|.:|::
Mouse   558 QMGKVNKKELLK 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	151/591 (26%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	121/396 (31%)
Acsf3	NP_659181.2	MCS	55..569	CDD:341264	147/570 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R434
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840