DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12512 and SPCC1827.03c

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001342732.1	Gene:	SPCC1827.03c / 2539253	PomBaseID:	SPCC1827.03c	Length:	512	Species:	Schizosaccharomyces pombe

Alignment Length:	551	Identity:	144/551 - (26%)
Similarity:	234/551 - (42%)	Gaps:	78/551 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 GD--VEAIVSCHEGKRYSFKSLLQEADALAAGFRKLGLQPGDAVGLWAPNYLHWYLGMMGAARAG 123
            ||  ..|:|:.......||..|......|......||::.||.|.:..||.|.:.:.....:...
pombe    12 GDASARALVAPSLNAELSFSELRIAIMDLQRQIASLGIKVGDPVNIAIPNGLEFVVAFYAVSWQR 76

  Fly   124 LTSVGLNPAYQGPEIAYCLNKVNVKAIIAPETFKTQNYYEI---------LRDI--CPEISDADT 177
            .....||..|:..|..:.::.:..|.:|.||.....|...:         :.::  ||
pombe    77 AICGPLNSNYKQSEFEFYIDDLKSKLVIVPEGSVAANTPAVRAAKKLSVAVAELAWCP------- 134

  Fly   178 GKIRSEKFPHLRSVIIDSNDSLKGALRFDDFLDLASKSEREEVAKMQKSILPESACNIQFTSGTT 242
             |.|..:..|.....|::...| |..:.||.:                        .:..|||||
pombe   135 -KSRLVRIVHFEGAKINAPQPL-GLPQPDDVM------------------------LVLHTSGTT 173

  Fly   243 GNPKAACLTHHNFVNNGIHVGNRNELE-GERICVQVPMFHAFGVIISIMAALTKGATMVLPAAGF 306
            |.||...|||.|...:..::.....|: .:...|.:|:||..|::..:::.|..|...|:|.. |
pombe   174 GRPKVVPLTHKNLCRSIHNITTSYRLDPRDTSYVVMPLFHVHGLLCGLLSTLASGGCAVVPPK-F 237

  Fly   307 SPKDSLQAIVNEKCSVIHGTPTMYVDLVNTQKKLQVPLGRIKKAVTGGAIVSPQLIKDVRQVLNV 371
            |.....:..:....:.....||::..|:.|..  ..||.||:...:..:.::|.::..:......
pombe   238 SAHSFWKEFIQYGATWYTAVPTIHQILLRTPP--PKPLPRIRFIRSCSSPLAPPVLSKLEATFRA 300

  Fly   372 EAVHSVYGLTETTAVIFQSLPGDSSDVVLNSVGHLTDH---------IEAKVVDAEGRCVPFGQP 427
            ..:.: |.:||.           |..:..|.:..|...         :|.|::|.:|..:|.|:.
pombe   301 PVLEA-YAMTEA-----------SHQMTTNPLPPLVHKPHSVGKPFGVELKILDQKGNEMPQGKE 353

  Fly   428 GELCVRGYTTMLGYHDDEEKTKETIGNDRWLRTGDQFVLEANGYGRIVGRLKEMLIRGGENIFPK 492
            ||:||||.....||.::....|.:...||:.||||:..|:.:||..|.||:||::.||||.|.|.
pombe   354 GEICVRGINVTKGYLNNPAANKSSFTKDRFFRTGDEGKLDKDGYVFITGRIKELVNRGGEKISPA 418

  Fly   493 EIEDFLNAHPQVIEAHVIGVPDERLGEEVCAYVRLEEGVDPASFTAETLKAYAKGKLAHFKVPRY 557
            ||:..|..||.|.||....||||:.|:::.|.:....|   .:.|.:.|..|.:.|:|.||:|:.
pombe   419 EIDAVLMQHPDVSEAVCFAVPDEKYGQDIQAAINPVAG---KTVTPKQLHDYLEQKVAAFKIPKK 480

  Fly   558 VIPIDAFPKTTSGKIQKFKLVEAF----KAK 584
            ....|..|||.:||:|:..:.:||    |||
pombe   481 FYFTDRIPKTATGKVQRRLVCDAFFNHSKAK 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	144/551 (26%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	104/357 (29%)
SPCC1827.03c	NP_001342732.1	FACL_fum10p_like	160..502	CDD:213292	106/383 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	51	1.000	Domainoid score	I3347
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47353
orthoMCL	1	0.900	-	-		OOG6_100107
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R434
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.740