DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12512 and Acsm3

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	XP_006230168.1	Gene:	Acsm3 / 24763	RGDID:	62086	Length:	581	Species:	Rattus norvegicus

Alignment Length:	622	Identity:	156/622 - (25%)
Similarity:	255/622 - (40%)	Gaps:	108/622 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 MLRQKCAFNSM----------RSISTSMPSLISH----KH----------HIGKDPLVYRTIGQQ 52
            :||.:| |:.:          :...|::|...|:    ||          :..||.|...|..::
  Rat     4 LLRARC-FHRLAIPDPRRILYKDYRTAIPQNFSNYESMKHDFKIEIPEYFNFAKDVLDQWTNTEK 67

  Fly    53 LELSASN--FGDVEAIVSCHEGK--RYSFKSLLQEADALAAGFRKL-----GLQPGDAVGLWAPN 108
            .....||  |..|:.     .||  |:||    :|..:|:..|..:     .||.||.|.:..|.
  Rat    68 TGKRLSNPAFWWVDG-----NGKEVRWSF----EELGSLSRKFANILTEACSLQRGDRVMVILPK 123

  Fly   109 YLHWYLGMMGAARAGLTSVGLNPAYQGPEIAYCLNKVNVKAIIAPETFKTQNYYEILRDICPEIS 173
            ...|:|..:...|.|...:.........:|.|.|.....|.||..:|            :.|.:.
  Rat   124 IPEWWLANVACLRTGTVLIPGTTQLTQKDILYRLQSSKSKCIITDDT------------LAPAVD 176

  Fly   174 DADTGKIRSEKFPHLRSVIIDSNDSLKGALRFDDFLDLASKSEREEVAKMQKSILPESACNIQFT 238
                  |.:.|..:|.|.:|.|..|.:|.....:.:..||.|......|..:.:.      |.||
  Rat   177 ------IVAAKCENLHSKLIVSQHSREGWGNLKEMMKYASDSHTCVDTKHNELMA------IYFT 229

  Fly   239 SGTTGNPKAACLTHHNFVNNGIHVGNRNELEGERICVQVPMFH------AFGVIISIMAALTKGA 297
            |||||.||....||.:| ..|:.|..|..|:   :.....|::      |.....|:.:..|:||
  Rat   230 SGTTGPPKMIGHTHSSF-GLGLSVNGRFWLD---LIASDVMWNTSDTGWAKSAWSSVFSPWTQGA 290

  Fly   298 TM---VLPAAGFSPKDSLQAIVNEKCSVIHGTPTMYVDLVNTQKKLQVPLGRIKKAVTGGAIVSP 359
            .:   .||.  |.....||.:.....:|....||.|..|:............:|..|:.|..::|
  Rat   291 CVFAHYLPR--FDSTSILQTLSKFPITVFCSAPTAYRMLIQNDITRSYKFNSLKHCVSAGEPINP 353

  Fly   360 QLIKDVRQVLNVEAVHSVYGLTETTAVI--FQSL---PGDSSDVVLNSVGHLTDHIEAKVVDAEG 419
            ::::..::...:: ::..||.|||..:.  |:.:   ||        |:|..:.....:::|..|
  Rat   354 EVMEQWKKKTGLD-IYEGYGQTETVLICGNFKGMKIKPG--------SMGKPSPAFNVEILDENG 409

  Fly   420 RCVPFGQPGELCV-----RGYTTMLGYHDDEEKTKETIGNDRWLRTGDQFVLEANGYGRIVGRLK 479
            ..:|.||.|::.|     |.:.....|.|:..||..|:..:.:: |||:..::.:||...|.|..
  Rat   410 TILPPGQEGDIAVQVLPDRPFGLFTHYVDNPSKTASTLRGNFYI-TGDRGYMDEDGYFWFVARSD 473

  Fly   480 EMLIRGGENIFPKEIEDFLNAHPQVIEAHVIGVPDERLGEEVCAYVRLEEGVDPASFTAETLK-- 542
            ::::..|..|.|.|:|..|..||.:.|:.|:..||...||.|.|::.|..  |......|.||
  Rat   474 DVILSSGYRIGPFEVESALIEHPSIAESAVVSSPDPIRGEVVKAFIVLNP--DYKLHDQEQLKKE 536

  Fly   543 --AYAKGKLAHFKVPRYVIPIDAFPKTTSGKIQKFKL 577
              .:.|...|.:|.||.:..|:..|||.|||:::.:|
  Rat   537 IQEHVKKTTAPYKYPRKIEFIEELPKTVSGKVKRNEL 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	145/567 (26%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	100/370 (27%)
Acsm3	XP_006230168.1	Acs	45..575	CDD:223442	147/580 (25%)
Acsm3	XP_006230168.1	AFD_class_I	48..578	CDD:302604	147/577 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910