DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12512 and Acsm2

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_653349.1	Gene:	Acsm2 / 246263	RGDID:	708383	Length:	572	Species:	Rattus norvegicus

Alignment Length:	544	Identity:	141/544 - (25%)
Similarity:	237/544 - (43%)	Gaps:	82/544 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 EGKRYSFKSL----LQEADALAAGFRKLGLQPGDAVGLWAPNYLHWYLGMMGAARAGLTSVGLNP 131
            |..:::|:.|    .|.|:.|...   .|||.||.|.:..|....|:|..:|..|:||..:....
  Rat    77 EELKWNFRELSEISKQTANVLTGA---CGLQRGDRVAVVLPRVPEWWLVTLGCMRSGLVFMPGTT 138

  Fly   132 AYQGPEIAYCLNKVNVKAIIAPETFKTQNYYEILRDICPEISDADTGKIRSEKFPHLRSVIIDSN 196
            ..:..:|.|.|.....:||:|.:        |:::::.....|....||:          ::.|.
  Rat   139 QMKSTDILYRLQSSKARAIVAGD--------EVVQEVDAVAPDCSFLKIK----------LLVSE 185

  Fly   197 DSLKGALRFDDFLDLASKSEREEVAKMQKSILPESACNIQFTSGTTGNPKAACLTHHNFVNNGIH 261
            .:.:|.|.|...|..||     .:.:..:::..|||. |.|||||:|.||.|   .|:..:.|:.
  Rat   186 KNREGWLNFKALLKDAS-----PIHQCVETVSQESAA-IYFTSGTSGPPKMA---EHSHCSLGLK 241

  Fly   262 VGNRNELEGERICVQVPMFHAFGVIISIMAALTKGATM-------VLPAAGFSPKDSLQAIVNEK 319
            ........|......:......|.|::|:.:..:...:       :||.  |.|:..|:.:.:..
  Rat   242 AKMDAGWTGLGPSDTMWTISDTGWILNILGSFLEPWVLGTCIFVHLLPK--FDPQTVLKVLSSYP 304

  Fly   320 CSVIHGTPTMYVDLVNTQKKLQVPLGRIK-----KAVTGGAIVSPQLIKDVRQVLNVEAVHSVYG 379
            .:.:.|.|.:|      :..||..|...|     ...:||..:.|:.::..:....:| :..:||
  Rat   305 INTLLGAPLIY------RMLLQQDLSSYKFPHLHSCFSGGETLLPETLESWKAKTGLE-IREIYG 362

  Fly   380 LTET--TAVIFQSL---PGDSSDVVLNSVGHLTDHIEAKVVDAEGRCVPFGQPGELC-----VRG 434
            .|||  |..:.:::   ||        .:|......:.:|:|.:|..:|.|:.|::.     :|.
  Rat   363 QTETGITCRVSRTMKVKPG--------YLGTAIVPYDVQVIDEQGNVLPPGKEGDMALRVKPIRP 419

  Fly   435 YTTMLGYHDDEEKTKETIGNDRWLRTGDQFVLEANGYGRIVGRLKEMLIRGGENIFPKEIEDFLN 499
            .....||.|:.:||:..|..|.|| .||:.:.:..||...:||..:::...|..|.|.|:|:.|.
  Rat   420 IGMFSGYVDNPKKTQANIRGDFWL-LGDRGIKDTEGYFHFMGRTDDIINSSGYRIGPSEVENALM 483

  Fly   500 AHPQVIEAHVIGVPDERLGEEVCAYVRLEE---GVDPASFTAETLKAYAKGKLAHFKVPRYVIPI 561
            .||.|:|..||..||....|.|.|:|.|..   ..|....| :.|:.:.|...|.:|.||.|..:
  Rat   484 EHPAVVETAVISSPDPIRREVVKAFVVLAPEFLSHDQDQLT-KVLQEHVKSVTAPYKYPRKVEFV 547

  Fly   562 DAFPKTTSGKIQKFKLVEAFKAKE 585
            ...|||.:|||::.||    :|||
  Rat   548 LDLPKTITGKIERAKL----RAKE 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	141/544 (26%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	100/372 (27%)
Acsm2	NP_653349.1	AFD_class_I	40..568	CDD:302604	141/544 (26%)
		Acs	40..565	CDD:223442	138/540 (26%)
		Coenzyme A binding. /evidence=ECO:0000250	469..471		0/1 (0%)
		Coenzyme A binding. /evidence=ECO:0000250	540..542		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910