DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12512 and ACSL4

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	XP_024308119.1	Gene:	ACSL4 / 2182	HGNCID:	3571	Length:	717	Species:	Homo sapiens

Alignment Length:	678	Identity:	137/678 - (20%)
Similarity:	231/678 - (34%)	Gaps:	194/678 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 TIGQQLELSASNFGDVEAI----VSCHEGKRYS----FKSLL-------------QEADALAAGF 91
            |:.:..:.:.|.||..:::    :...|.:...    ||.|:             :..:...:|.
Human    84 TLDKLFDHAVSKFGKKDSLGTREILSEENEMQPNGKVFKKLILGNYKWMNYLEVNRRVNNFGSGL 148

  Fly    92 RKLGLQPGDAVGLWAPNYLHWYLGMMGAARAGLTSVGLNPAYQGPEIAYCLNKVNVKAIIAPETF 156
            ..|||:|.:.:.::......|.:......:.....|.|........:.:.||:.....:|.....
Human   149 TALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGKEAVVHGLNESEASYLITSVEL 213

  Fly   157 KTQNYYEILRDI-CPEISDADTGKIRSEKFPHLRSVIIDSNDSLKGALRFDDFLDLASKSEREEV 220
            ........|.|| |                  ::.:|...|.::..| .:.:..::.|....||:
Human   214 LESKLKTALLDISC------------------VKHIIYVDNKAINKA-EYPEGFEIHSMQSVEEL 259

  Fly   221 AKMQKSI-------LPESACNIQFTSGTTGNPKAACLTHHNFVNNGIHVGNRNELEG----ERIC 274
            ....:::       .|.....:.:|||:||.||...:.|.|.:..  ..|....:.|    :...
Human   260 GSNPENLGIPPSRPTPSDMAIVMYTSGSTGRPKGVMMHHSNLIAG--MTGQCERIPGLGPKDTYI 322

  Fly   275 VQVPMFH-----------AFGVIISIMAALT------------KGATMVLPAAGFSPKDSLQAIV 316
            ..:|:.|           .:|..|...:.||            ||...||       |.:|.|.|
Human   323 GYLPLAHVLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVL-------KPTLMAAV 380

  Fly   317 NEKCSVIHGTPTMYVDLVN-TQKKL----------------QVPL--------------GRIKKA 350
            .|....|:......|..:| .||.|                ..||              |.::..
Human   381 PEIMDRIYKNVMSKVQEMNYIQKTLFKIGYDYKLEQIKKGYDAPLCNLLLFKKVKALLGGNVRMM 445

  Fly   351 VTGGAIVSPQLIKDVRQVLNV---EAVHSVYGLTETTAVIFQSLPGDSSDVVLNSVGHLTDHIEA 412
            ::|||.:|||    ..:.:||   ..:...|||||:...   ....:.:|.....||......|.
Human   446 LSGGAPLSPQ----THRFMNVCFCCPIGQGYGLTESCGA---GTVTEVTDYTTGRVGAPLICCEI 503

  Fly   413 KVVD-AEGRCVPFGQP---GELCVRGYTTMLGYHDDEEKTKETIGND----RWLRTGDQFVLEAN 469
            |:.| .||......:|   ||:.:.|....:||..:||||.|....|    ||..|||......:
Human   504 KLKDWQEGGYTINDKPNPRGEIVIGGQNISMGYFKNEEKTAEDYSVDENGQRWFCTGDIGEFHPD 568

  Fly   470 GYGRIVGRLKEML-IRGGENIFPKEIEDFLNAHPQVIEAHVIGVPDERLGEEVCAYVRLEE---- 529
            |..:|:.|.|::: ::.||.:...::|..|...|.:              :.:||:.:.::
Human   569 GCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLI--------------DNICAFAKSDQSYVI 619

  Fly   530 -----------------GVD---------PASFTAETLKAYAKGKLAHFKVPRYVIPIDA----- 563
                             ||:         || ..||.||...:...| .|:.|:.|||..
Human   620 SFVVPNQKRLTLLAQQKGVEGTWVDICNNPA-MEAEILKEIREAANA-MKLERFEIPIKVRLSPE 682

  Fly   564 --FPKTTSGKIQKFKLVEAFKAKETELK 589
              .|:|  |.:     .:|||.|..||:
Human   683 PWTPET--GLV-----TDAFKLKRKELR 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	137/678 (20%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	102/454 (22%)
ACSL4	XP_024308119.1	LC-FACS_euk	127..714	CDD:213293	129/635 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910