DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12512 and ACSL3

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001341087.1	Gene:	ACSL3 / 2181	HGNCID:	3570	Length:	720	Species:	Homo sapiens

Alignment Length:	702	Identity:	152/702 - (21%)
Similarity:	259/702 - (36%)	Gaps:	201/702 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TISRYMLRQKCAFNSMRSISTSMPSLISHKHHIGKDPLVYRTI--GQQLELS-------ASNFGD 62
            |:.:.....|..|.:.|.:.|.  .:::.:..:..:..:::.:  ||...||       |.|||:
Human    87 TLDKVFTYAKNKFKNKRLLGTR--EVLNEEDEVQPNGKIFKKVILGQYNWLSYEDVFVRAFNFGN 149

  Fly    63 VEAIVSCHEGKRYSFKSLLQEADALAAGFRKLGLQPGDAVGLWAPNYLHWYLGMMGAARAGLTSV 127
                                       |.:.||.:|...:.::......|.:............|
Human   150 ---------------------------GLQMLGQKPKTNIAIFCETRAEWMIAAQACFMYNFQLV 187

  Fly   128 GLNPAYQGPEIAYCLNKVNVKAII-APETFKTQNYYEILRDI---CPEISDADT--GKIRS-EKF 185
            .|.....||.|.:.||:..|..|| :.|..:|:     |:||   .|.:....|  ||..: .:|
Human   188 TLYATLGGPAIVHALNETEVTNIITSKELLQTK-----LKDIVSLVPRLRHIITVDGKPPTWSEF 247

  Fly   186 PHLRSVIIDSNDSLKGALRFDDFLDLASKSEREEVAKMQKSILPESACNIQFTSGTTGNPKAACL 250
            |  :.:|:.:..:::.         |.:|:..|.  :.....||.....|.:|||:||.||...:
Human   248 P--KGIIVHTMAAVEA---------LGAKASMEN--QPHSKPLPSDIAVIMYTSGSTGLPKGVMI 299

  Fly   251 THHNFV--------------NNGIHVG-----NRNELEGERICVQVPMFHAFGVIISIMAAL--- 293
            :|.|.:              ...:::|     :..||..|.:|:.    |...:..|....|
Human   300 SHSNIIAGITGMAERIPELGEEDVYIGYLPLAHVLELSAELVCLS----HGCRIGYSSPQTLADQ 360

  Fly   294 -------TKGATMVLPAAGFSPKDSLQAIVNEKCSVIHGTPTMYV-DLVNTQKKL---------- 340
                   :||.|.:|       |.:|.|.|.|....|:......| ::.:.|:.|
Human   361 SSKIKKGSKGDTSML-------KPTLMAAVPEIMDRIYKNVMNKVSEMSSFQRNLFILAYNYKME 418

  Fly   341 ------QVPL--------------GRIKKAVTGGAIVSPQLIKDVRQVLNV---EAVHSVYGLTE 382
                  ..||              |.|:..:.|||.:|    ...::.:|:   ..|...|||||
Human   419 QISKGRNTPLCDSFVFRKVRSLLGGNIRLLLCGGAPLS----ATTQRFMNICFCCPVGQGYGLTE 479

  Fly   383 TTAVIFQSLPGDSSDVVLNSVGHLTDHI---EAKVVD-AEGRCVPFGQP---GELCVRGYTTMLG 440
            :...      |..|:|...:.|.:...:   |.|:.: .||......:|   ||:.:.|.:..:|
Human   480 SAGA------GTISEVWDYNTGRVGAPLVCCEIKLKNWEEGGYFNTDKPHPRGEILIGGQSVTMG 538

  Fly   441 YHDDEEKTK----ETIGNDRWLRTGDQFVLEANGYGRIVGRLKEML-IRGGENIFPKEIE----- 495
            |:.:|.|||    |.....|||.|||....|.:|..:|:.|.|::: ::.||.:...::|
Human   539 YYKNEAKTKADFFEDENGQRWLCTGDIGEFEPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAALKN 603

  Fly   496 ----DFLNAHPQVIEAHVIG--VPDER-------------LGEEVCAYVRLEEGVDPASFTAETL 541
                |.:.|:.....::|||  ||:::             ..||:|....:|.         |.|
Human   604 LPLVDNICAYANSYHSYVIGFVVPNQKELTELARKKGLKGTWEELCNSCEMEN---------EVL 659

  Fly   542 K----AYAKGKLAHFKVPRYVIPIDAFPKTTSGKIQKFKLVEAFKAKETELK 589
            |    |.....|..|::| ..|.:...|.|....:    :.:|||.|..|||
Human   660 KVLSEAAISASLEKFEIP-VKIRLSPEPWTPETGL----VTDAFKLKRKELK 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	147/666 (22%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	101/450 (22%)
ACSL3	NP_001341087.1	AFD_class_I	30..717	CDD:418409	152/702 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910