DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12512 and ACSL1

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001273637.1	Gene:	ACSL1 / 2180	HGNCID:	3569	Length:	698	Species:	Homo sapiens

Alignment Length:	669	Identity:	155/669 - (23%)
Similarity:	248/669 - (37%)	Gaps:	187/669 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 DPLVY-----RTI--GQQLELSASNFGDVEAIVSCHEGKR-------YSFKSLLQEADALAAGFR 92
            :||||     .|:  |.|..:..||.|      .|...::       .|:|.:.:.::.:.:...
Human    80 EPLVYFYDDVTTLYEGFQRGIQVSNNG------PCLGSRKPDQPYEWLSYKQVAELSECIGSALI 138

  Fly    93 KLGLQ--PGDAVGLWAPNYLHWYLGMMGAARAGLTSVGLNPAYQGPEIAYCLNKVNVKAIIAPET 155
            :.|.:  |...:|::|.|...|.:...|.....:..|.|........|.|.:||..:..:...:.
Human   139 QKGFKTAPDQFIGIFAQNRPEWVIIEQGCFAYSMVIVPLYDTLGNEAITYIVNKAELSLVFVDKP 203

  Fly   156 FKTQNYYEILRDICPEISDADTGKIRSEKFPHLRSVII-DSNDSLKGALRFDDFLDLASKSER-- 217
            .|.:...|               .:.::..|.|:.::: |:..|           :|..:.:|
Human   204 EKAKLLLE---------------GVENKLIPGLKIIVVMDAYGS-----------ELVERGQRCG 242

  Fly   218 EEVAKMQ-------------KSILPESACNIQFTSGTTGNPKAACLTHHNFVN----------NG 259
            .||..|:             |...||....|.||||||||||.|.:||.|.|:          |.
Human   243 VEVTSMKAMEDLGRANRRKPKPPAPEDLAVICFTSGTTGNPKGAMVTHRNIVSDCSAFVKATENT 307

  Fly   260 IHVGNRNELEGERICVQVPMFHAFGVIISIMAALTKGATMVLPAAGFSPKDSLQAIVNEKCSVIH 324
            :     |....:.:...:|:.|.|..::..: .|..||.:     ||...|.  .::.:...|:.
Human   308 V-----NPCPDDTLISFLPLAHMFERVVECV-MLCHGAKI-----GFFQGDI--RLLMDDLKVLQ 359

  Fly   325 GTPTMY--------------------------VDLVNTQK---------------------KLQV 342
              ||::                          :|..:.:|                     |:|.
Human   360 --PTVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQS 422

  Fly   343 PL-GRIKKAVTGGAIVSPQLIKDVRQVLNVEAVHSVYGLTETTAVIFQSLPGDSSDVVLNSVGH- 405
            .| ||::..|||.|.||..::..:|..|..: .:..||.||.||....::|||.      :.||
Human   423 SLGGRVRLMVTGAAPVSATVLTFLRAALGCQ-FYEGYGQTECTAGCCLTMPGDW------TAGHV 480

  Fly   406 ----------LTDHIEAKVVDAEGRCVPFGQPGELCVRGYTTMLGYHDDEEKTKETIGNDRWLRT 460
                      |.|..|...:.|||.       ||:||:|.....||..|..||.|.:..|.||.|
Human   481 GAPMPCNLIKLVDVEEMNYMAAEGE-------GEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHT 538

  Fly   461 GDQFVLEANGYGRIVGRLKEML-IRGGENIFPKEIEDF---------LNAHPQVIEAHVIG--VP 513
            ||......||..:|:.|.|.:. :..||.|.|::||:.         :..|.:.::|.:|.  ||
Human   539 GDIGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVP 603

  Fly   514 DERLGEEVCAYVR---LEEGVDPASFTAETLKAYAK-----GKLAHFKVPRYVIPIDAFPKTTSG 570
            |.   |.:|::.:   .|...:......:..||..:     ||.:..|....|..|...|:..|
Human   604 DV---ETLCSWAQKRGFEGSFEELCRNKDVKKAILEDMVRLGKDSGLKPFEQVKGITLHPELFS- 664

  Fly   571 KIQKFKLVEAFKAKETELK 589
             |....|....|||..||:
Human   665 -IDNGLLTPTMKAKRPELR 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	155/668 (23%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	111/436 (25%)
ACSL1	NP_001273637.1	LC-FACS_euk	116..694	CDD:341250	144/627 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910