DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12512 and nrps-1

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_499488.3	Gene:	nrps-1 / 190498	WormBaseID:	WBGene00013440	Length:	2942	Species:	Caenorhabditis elegans

Alignment Length:	681	Identity:	141/681 - (20%)
Similarity:	233/681 - (34%)	Gaps:	197/681 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 MRSISTSMPSLISHKHHIGKDP--LVYRTIGQQLELSASNFGDVEAIVSCHEGKRYSFK----SL 80
            :.|:.|...:|..|:.| |..|  ::.:..|:..........||..:|...:.:|..|:    .:
Worm   697 LESLKTCQKTLKDHRSH-GSIPFEVIAKLSGEGDLFQIFVVSDVVDVVEDAKKRRVRFEDEACEV 760

  Fly    81 LQEADALAAGFRKLGLQPGDAVGLWAPNYLHWYLGMMGAARAGLTSVGLNPAYQGPEIAYC--LN 143
            ||..:.|    |::...|           :.|||......:.              |:.|.  |.
Worm   761 LQNPEEL----RRIAKYP-----------MTWYLRQSDRLQI--------------EVEYSEDLF 796

  Fly   144 KVNVKAIIAPETFKTQNYYEILRDICPEISDADTGKIRSEKFPHLRSVI-----IDSNDS----- 198
            |.:...:|..:.|:..|::|..|:        :.|.||...||  ||.:     :.::.|
Worm   797 KKDTIELILEDMFRIFNHFEGGRE--------EPGLIRRSDFP--RSTVSQIIGLSASSSPTLRV 851

  Fly   199 ------------------LKGALRFDDFL-------------------------------DLASK 214
                              |||.::....|                               .:...
Worm   852 RYSSKDWKLNTRQLAGHILKGHIQKHGQLITEYPLVLKMPRTPALVEAVLAAWEAGLYPVPMHKD 916

  Fly   215 SEREEVAK-----------------------MQKSILPESACNIQFTSGTTGNPKAACLTHHNFV 256
            |:..::.|                       ..||||.:.| .:..|||:||.||....:.....
Worm   917 SKEAQIEKTLEALGIEEAFDSKDLCQTKLRIFNKSILYDLA-YVTSTSGSTGTPKLVGTSFEGHS 980

  Fly   257 NNGIHVGNRNELEGERICVQV--PMFHAFGVIISIMAALTKGATMVLPAAGFSPKDSLQAIVNEK 319
            |.........::.......||  |.|..|  ...|:..|..||.::|.....|..:.|.     :
Worm   981 NLARQYTTTYQISSRDTVGQVVDPSFDIF--FADIVKTLVNGARLLLARDSISTSEELL-----E 1038

  Fly   320 CSVIHGTPTMY-----VDLVNTQKKLQVPLGRIKKAVTGGAIVSPQLIKDVRQVLNVEAVHSVYG 379
            |:.::..|...     ::.:|..:.||.          ||...:|.::|.:........|...:|
Worm  1039 CTNVYLMPAFLSRIPCIESLNNLESLQY----------GGEPCAPHVLKQIFGAHQNLRVWQEFG 1093

  Fly   380 LTETTA------VIFQSLPGDSSDVVLNSVGHLTDHIEAKVVDAEGRCVPFGQPGELCVRGYTTM 438
            |||.|.      :..:||   :|...|..:|...|:|:..|   ||        .:|.:.|...|
Worm  1094 LTEQTVYSARQRIYPRSL---TSLDDLRRIGEPFDNIQLGV---EG--------SQLVLSGVGLM 1144

  Fly   439 LGYHDDEEKTKETIGNDRWLRTGDQFVLEANGYGRIVGRLKEMLIRGGENIFPKEIEDFLNAHPQ 503
            .||..   .|::.:..   |.|||:......|....:||....:...|..|      |.......
Worm  1145 RGYFG---VTRQPLNK---LNTGDEVSKRKQGGLIFMGRKDSQVKVRGHRI------DLFEIECA 1197

  Fly   504 VIEAHVIGVPDERLGEEVCAYVRLEEGVDPASFTAETLKAYAKGKLAHFKVPRYVIPIDAFPKTT 568
            .:.:::|......:||.....:..:|..:|.  |.|.||.:.:.:|..:|||..::.:|:||.|.
Worm  1198 ALSSNLIDSCSCVVGENCQLVLFFKENENPD--TQEKLKNHLEKELIAYKVPSRLVGLDSFPLTR 1260

  Fly   569 SGKIQKFKLVEAFKAKET--------ELKAA 591
            :|||.|.||||...|.:|        |.|||
Worm  1261 TGKIDKKKLVELSNASQTSHVGSEVLERKAA 1291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	135/660 (20%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	83/360 (23%)
nrps-1	NP_499488.3	Condensation	441..686	CDD:305010
		HxxPF_rpt	712..802	CDD:290463	21/119 (18%)
		AFD_class_I	860..1269	CDD:302604	93/454 (20%)
		AA-adenyl-dom	860..1207	CDD:273779	73/390 (19%)
		PP-binding	1312..1361	CDD:278949
		Condensation	1379..1606	CDD:305010
		PP-binding	1712..1776	CDD:278949
		Condensation	1800..>1941	CDD:305010
		AFD_class_I	2223..2641	CDD:302604
		AA-adenyl-dom	2253..2578	CDD:273779
		PP-binding	2661..2723	CDD:278949
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910