DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12512 and acs-17

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001360705.1	Gene:	acs-17 / 180859	WormBaseID:	WBGene00016716	Length:	721	Species:	Caenorhabditis elegans

Alignment Length:	685	Identity:	149/685 - (21%)
Similarity:	249/685 - (36%)	Gaps:	174/685 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 KHHIGKDPLV------YRTIGQQLELSASNFGD-----VEAIVSCHEGKR-------------YS 76
            |:...||.|:      ...:|.|.|.....:|:     ...::..|:.|:             |.
Worm    72 KNVSAKDGLMNSSFEGIHDLGTQWEECVRRYGNQPCMGTREVLKVHKEKQSNGKIFEKWQMGDYH 136

  Fly    77 FKSLLQ---EADALAAGFRKLGLQPGDAVGLWAPNYLHWYLGMMGAARAGLTSVGLNPAYQGPEI 138
            ::|..|   ..:.:|:|...||.|..:.:.|:|.....|....:...:.......:........:
Worm   137 WRSYAQVDKRVNMIASGLTSLGQQEKEPIILFAETREEWMTTALACMKMNFPIATMYATLGDEAV 201

  Fly   139 AYCLNKVNVKAIIAPETFKTQ------NYYEILRDIC--PEISDADTGKIRSEKFPHLRSVIIDS 195
            .:.:|:|..|.|...|...::      |....:.:|.  ..:..|..|:          ||.:|.
Worm   202 QFAINEVGAKTIFTSEALISKVKKAMSNGATSIENIIFFDSVDPASRGE----------SVDVDL 256

  Fly   196 NDSLKGALRFDDFLDLASKSEREEVAKMQKSILPESACNIQFTSGTTGNPKAACLTHHNFVNNGI 260
            ..:|   |.||..|   |:.|||....:......:....|.:|||||||||...::|.|.|  .:
Worm   257 PFTL---LSFDQLL---SRGEREYSYPVPTRSKKDDLAFIMYTSGTTGNPKGVMISHQNIV--AV 313

  Fly   261 HVGNR-NELEG--ERICVQVPMFHAFGVIISIMAALTKGATMVLPAAGFSPKDSLQAIVNEKCSV 322
            ..|.. |.:.|  :|....:|:.|...|... |...|||..:     |:|   |.|.:.:....:
Worm   314 TAGQAFNIVLGPDDRYIGYLPLAHILEVCAE-MVVFTKGVRI-----GYS---SAQTLFDRAPKI 369

  Fly   323 IHG--------TPTM--------------YVDLVNTQKKLQVPL--------------------- 344
            :.|        .||:              .:|.||...:|...|
Worm   370 MKGEHGDCWVLQPTLMACVPAVMDRIFKAVIDEVNANSELFKQLFKTCYERKRSRYEEGYTSFIL 434

  Fly   345 -------------GRIKKAVTGGAIVSPQLIKDVRQVLNV---EAVHSVYGLTETTAVIFQSLPG 393
                         |::::.::|||.:||    :.::.:|:   ..|...||||||..   .....
Worm   435 NKLVFNRIGKLLGGKVRQILSGGAPLSP----ETQRFMNICFCCPVVQGYGLTETCG---GGTIA 492

  Fly   394 DSSDVVLNSVGHLTDHIEAKVVD-AEGRCVPFGQP--GELCVRGYTTMLGYHDDEEKTKE---TI 452
            |..|:...:||......|..:.: ||....|...|  ||:.:.|....|||..::|||||   .:
Worm   493 DIHDLSTGTVGPPLTCCEILLQEWAEAGYSPKNDPPQGEILISGPNVALGYFKNDEKTKEEFVKV 557

  Fly   453 GNDRWLRTGDQFVLEANGYGRIVGRLKEML-IRGGENIFPKEIEDFLNAHPQVIEAHVIG----- 511
            ....:..|||......:|..:|:.|.|::| :..||.|...::|..|..:|.|....|.|
Worm   558 NGKTFFATGDIGEFREDGSLKIIDRKKDLLKLAHGEYISLGKVETNLLTNPNVDNVCVYGDSNKS 622

  Fly   512 ------VPDE--------RLG------EEVCAYVRLEEGVDPASFTAETLKAYAKGKLAHFKVPR 556
                  ||::        :.|      |::|...::.|.:.      :.|..|...||...::|:
Worm   623 FLVALVVPNQKNLTQLASKAGASNDNFEKLCEDKKVVEALQ------KELAQYGASKLQRVEIPQ 681

  Fly   557 YVIPIDAFPKTTSGKIQKFKLVEAFKAKETELKAA 591
            .:. |...|.|.:..:    |.||.|.|...::.|
Worm   682 KIF-ICHEPWTPASGL----LTEALKLKRKNIEKA 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	146/678 (22%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	101/441 (23%)
acs-17	NP_001360705.1	LC_FACS_euk1	133..708	CDD:341294	138/619 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910