DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12512 and pks-1

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_508923.2	Gene:	pks-1 / 180815	WormBaseID:	WBGene00016558	Length:	7752	Species:	Caenorhabditis elegans

Alignment Length:	607	Identity:	112/607 - (18%)
Similarity:	208/607 - (34%)	Gaps:	188/607 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 NSMRSISTSMPSLISHKHHIGKDPLVYRTIGQQLELSASNFGDVEAIVSCHEGKRYSFKSLLQEA 84
            |::|:::|::|        |.:.........:.|..|...|.:...::|.:   ..|:..|.::.
Worm  6955 NNLRNMNTTIP--------IRRTDFPSTLFQKGLFTSWRLFTEPALLLSTN---TVSYSDLAEKI 7008

  Fly    85 DALAAGFRK-------LGLQPGDAVGLWAPNYLHWYLGMMGAARAGLTSVGLNPAYQGPEIAYCL 142
            :.::...:|       ..::..:.|||...|.   |..::.....||....::|.:..|...:..
Worm  7009 ENISKDIQKQLQIAKATSVREDELVGLDCKNS---YFALLACVFLGLPYAPIDPTWPEPRQLFVK 7070

  Fly   143 NKVNVKAIIAPETFKTQNYYEILRDICPEISDADTGKIRSEKFPHLRSVIIDSNDSLKGALRFDD 207
            :||         :|..:|        |                                   |..
Worm  7071 SKV---------SFTLEN--------C-----------------------------------FSC 7083

  Fly   208 FLDLASKSEREEVAKMQKSILPESACNIQFTSGTTGNPKAACLTHHNFVNNGIHVGNRNELEGER 272
            .|.|.:.:.|.:...:. ||         ||||:||.||...:...: |::.:...::..:....
Worm  7084 NLKLRNFNSRTQFGSIY-SI---------FTSGSTGVPKGVLMAEQS-VSSFMTSASKQCMFRSN 7137

  Fly   273 ICVQVPMFHAFGVIIS-IMAALTKGATMVLPAAGFSPKDSLQAIVNEKC-------SVIHGTPTM 329
            |.|...:...|.|.:| |:.::..|..::......:..|.||     ||       :|.:|
Worm  7138 IRVLDSVKQVFDVSVSNIIGSVLNGGVLISSEHSTTITDQLQ-----KCQYAFLPAAVFNG---- 7193

  Fly   330 YVDLVNTQKKLQVPLGRIKKAVTGGAIVSPQLIKDVRQVLNVEAVHSVYGLTETT---------- 384
            :.|  .|..:|:    .|:....||..||..:|:...:.........:||.|||.
Worm  7194 FTD--KTMSRLE----SIETLTIGGETVSDVVIETAMKKFPRLRTIQIYGPTETCIWSLTNKCKV 7252

  Fly   385 ------AVIFQSLPGDSSDVVLNSVGHLTDHIEAKVVDAEGRCVPFGQPGELCVRGYTTMLGYHD 443
                  :.:..||..::..:..|||   ..:::.|              |....|||.|...:
Worm  7253 STLNIGSALGDSLSNETCTICNNSV---RGNVQVK--------------GISLARGYITSAPH-- 7298

  Fly   444 DEEKTKETIGNDRWLRTGDQFVLEANGYGRIVGRLKEMLIRGGENIFPKEIEDFLNAHPQVIEAH 508
                  .|..:|.: .|||....:.|.. :.:||:...:...|..|...|||..|.....:::..
Worm  7299 ------GTPFSDIY-STGDIVDSKLNSL-QYIGRMDSQVKCKGVRINISEIEKELILCLGLLQIV 7355

  Fly   509 VIGVPDERLGEEVCAYVRLEEGVDPASFTAETLKAY---AKGKLAH----------FKVPRYVIP 560
            |:                         ::.:.|.|:   .|.||.|          .::|.|.:.
Worm  7356 VL-------------------------YSNQMLIAFIVDQKSKLLHDSLVKTLKNRTQIPDYFVQ 7395

  Fly   561 IDAFPKTTSGKIQKFKLVEAFK 582
            |:..|..:|||:.|..|::||:
Worm  7396 INKMPLNSSGKVDKSLLLQAFE 7417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	107/584 (18%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	77/384 (20%)
pks-1	NP_508923.2	PKS	13..394	CDD:238429
		PKS_KS	57..395	CDD:214836
		KAsynt_C_assoc	<376..>433	CDD:292814
		PP-binding	736..799	CDD:278949
		PKS_KS	830..1197	CDD:214836
		PKS	830..1197	CDD:238429
		hot_dog	1544..1759	CDD:294345
		PKS_PP	<1806..1857	CDD:214834
		PKS	1889..2282	CDD:238429
		PKS_KS	1891..2282	CDD:214836
		PKS_PP	2790..2867	CDD:214834
		PKS_PP	2943..3024	CDD:214834
		PKS_KR	3203..3377	CDD:214833
		PP-binding	3485..3549	CDD:278949
		PksD	<3609..3984	CDD:225858
		PKS_AT	3649..3927	CDD:214838
		hot_dog	3994..4216	CDD:294345
		PKS	4290..4628	CDD:238429
		PRK14691	4335..4629	CDD:173154
		NADB_Rossmann	<4991..5131	CDD:304358
		PP-binding	5168..5230	CDD:278949
		PKS	5258..5645	CDD:238429
		PKS_KS	5260..5646	CDD:214836
		KAsynt_C_assoc	<5628..>5693	CDD:292814
		Acyl_transf_1	5761..6023	CDD:298668
		NADB_Rossmann	<6237..6393	CDD:304358
		PP-binding	6476..6539	CDD:278949
		Condensation	6558..6831	CDD:305010
		AFD_class_I	6990..7412	CDD:302604	101/557 (18%)
		AA-adenyl-dom	7000..7356	CDD:273779	85/463 (18%)
		PP-binding	7436..7499	CDD:278949
		Abhydrolase	7527..>7622	CDD:304388
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910