DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12512 and acs-12

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_508035.1	Gene:	acs-12 / 180375	WormBaseID:	WBGene00009106	Length:	550	Species:	Caenorhabditis elegans

Alignment Length:	547	Identity:	133/547 - (24%)
Similarity:	237/547 - (43%)	Gaps:	79/547 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 FGDVEAIVSCHEGKRYSFKSLLQEADALAAGFRKLGLQPGDAVGL---WAPNYLHWYLGMMGAAR 121
            |.:..|::......:::|:.::|:||.:|.....|.::..:.|.|   |:|..:  |:. :||:.
Worm    28 FREDVALIDNDTFAQFTFQDVMQKADFIAKSLVYLKVEKSEVVLLVMDWSPAAI--YIA-LGASM 89

  Fly   122 AGLTSVGLNPAYQGPEIAYCLNKVNVKAIIA--------PETFKTQN-YYEILRDICPEISDADT 177
            ||.....::|..|..|:.:.:.:...:.:.:        .:..||.| .|.|   ||....|...
Worm    90 AGAAIQVVSPKLQAWEMQFPVKESESRFVFSDPLGLHEIDKLMKTLNREYRI---ICTGSRDFAN 151

  Fly   178 GKIRSEKFPHLRSVIIDSNDSLKGALRFDDFLDLASKSEREEVAKMQKSILPE-----SACNIQF 237
            |      :|     ||:               |||       .|..|...||:     ....:.:
Worm   152 G------YP-----IIE---------------DLA-------FAAKQNLPLPKIEPDTDIVYLPY 183

  Fly   238 TSGTTGNPKAACLTHHNFVNNGIHVGNRNE----LEGERICVQVPMFHAFGVIISIMAALTKGAT 298
            :||..|..|....||...|...:.:.|.::    ..|:.....:|:....| :.:|:.||..|.|
Worm   184 SSGIHGKRKGIVTTHKVMVAKTMVMWNTSKHHEFRRGDTTLTMIPLHKQCG-LDAILCALLNGLT 247

  Fly   299 MVLPAAGFSPKDSLQAIVNEKCSVIHGTPTMYVDLVNTQKKLQVPLGRIKKAVTGGAIVSPQLIK 363
             |:....|.....:..|...|...:|.||.:...::...:.....:..::..|||...|:.:|.:
Worm   248 -VVTEKNFCVHTFMTCIQRYKIRAVHLTPYLMNLMMFEAENHTYNIESLEWVVTGADAVTEELYE 311

  Fly   364 DVRQVL-NVEAVHSVYGLTETTAVIFQSLPGDSSDVVLNSVGHLTDHIEAKVVD-AEGRCVPFGQ 426
            :..::. :|:.|...||:|| ..:|.::...:.|.    |.|.||.::|.||:| ..|:.:...:
Worm   312 EFTEIFPSVKTVTQTYGMTE-VGLICRTYNKNYSP----SCGQLTANLEMKVLDILTGKELGPRE 371

  Fly   427 PGELCVRGYTTMLGYHDDEEKTKETIGNDRWLRTGDQFVLEANGYGRIVGRLKEMLIRGGENIFP 491
            .|::||:|......|.::.:.|:|.. .|.|.||||....:..|...:|.:||||:...|..:.|
Worm   372 KGQICVKGIAAESPYLNNPKATEEHF-LDGWRRTGDIGFFDEEGNVHLVDKLKEMIKVFGYQVIP 435

  Fly   492 KEIEDFLNAHPQVIEAHVIGVPDERLGEEVCAYVRLEEGVDPASFTAETLKAYAKGKLAHFKVPR 556
            ||||..|..|..|.||.|:.:.:|..||...|:|.|::|.   ..|.:.||.|...::..:|
Worm   436 KEIETLLLTHQAVEEAAVVAINNELSGERPVAFVVLKKGF---VATEDDLKDYVNKRVIRYK--- 494

  Fly   557 YVIPIDA---FPKTTSGKIQKFKLVEA 580
            :::.::.   .||:..|.:.:..|.||
Worm   495 HLVRVNITQFLPKSACGTLLRRLLAEA 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	133/547 (24%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	92/361 (25%)
acs-12	NP_508035.1	PLN02246	2..518	CDD:215137	130/542 (24%)
acs-12	NP_508035.1	Firefly_Luc_like	33..514	CDD:213279	129/533 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100107
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710