DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12512 and acs-21

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_503845.1	Gene:	acs-21 / 178751	WormBaseID:	WBGene00016849	Length:	517	Species:	Caenorhabditis elegans

Alignment Length:	572	Identity:	145/572 - (25%)
Similarity:	241/572 - (42%)	Gaps:	104/572 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 HHIGKDPLVYRTIGQQLELSASN--------FGDVEAIVSCHEGKRYSFKSLLQEADALAAGF-R 92
            ||:...  ::.|.|.:...||:|        ..|:..::...:|::.::...:|.|...|... .
Worm     4 HHLKSS--IHTTAGLRAATSAANNIISQANLQSDISKVLFIDDGRKITYGDFVQRAGQYATALTE 66

  Fly    93 KLGLQPGDAV-----------GLWAPNYLHWYLGMMGAARAGLTSVGLNPAYQGPEIAYCLNKVN 146
            |..::.||.|           .|:|           ...:.|...|.:|||....|.|:
Worm    67 KYKIKKGDRVMARVSKTTDTAALYA-----------ACLQIGALYVPVNPALTQSEAAH------ 114

  Fly   147 VKAIIAPETFKTQNYYEILRDICPEI-----SDADTGKIRSEKFPH-LRSVIIDS-----NDSLK 200
                             .::|..|.:     .|||    :...|.. |::|.||:     |:.:
Worm   115 -----------------YVKDAKPSLWITCKDDAD----QIAMFQRVLKTVCIDNPVEVINEKV- 157

  Fly   201 GALRFDDFLDLASKSEREEVAKMQKSILPESACNIQFTSGTTGNPKAACLTHHNFVNNG---IHV 262
                      ||.::.:.:...|.:.:...:|..|.|||||||.||.|.|:|....||.   :..
Worm   158 ----------LADEAGKRKACTMIEHVEKSNAATICFTSGTTGAPKGAVLSHGALTNNTNALVQE 212

  Fly   263 GNRNELEGERICVQVPMFHAFGVIISIMAALTKGATMVLPAAGFSPKDSLQAIVNEKCSVIHGTP 327
            ....|.:....|  :|:|||.|:..|:..:|...:: |:....|..:|..:.:.|  .:|..|.|
Worm   213 WGFTENDVNLHC--LPIFHAHGLYFSLHCSLFSHSS-VIWRPNFDAEDCSKHLKN--ATVFMGVP 272

  Fly   328 TMYVDLVNTQKKLQVPLGRIKKAVTGGAIVSPQLIKDVRQVLNVEAVHSVYGLTETTAVIFQSLP 392
            |.|..|:.|....:....:|:..::|.|.:|...:::..:... :.:...||:||...:....|.
Worm   273 TFYSRLLATNNFNKESFEKIRLFISGSAPLSVPTLEEFEKRTG-QVILERYGMTEAGVIASNPLK 336

  Fly   393 GDSSDVVLNSVGHLTDHIEAKVVDAEGRCVPFGQPGELCVRGYTTMLGYHDDEEKTKETIGNDRW 457
            |...   ..:||.....::.:|.          :.||:.::..:....|..:.|||||....|.|
Worm   337 GKRK---AGTVGQALKGVQCRVT----------ENGEIEIKSDSIFSEYWKNPEKTKEEFTEDGW 388

  Fly   458 LRTGDQFVLEANGYGRIVGRLKEMLIRGGENIFPKEIEDFLNAHPQVIEAHVIGVPDERLGEEVC 522
            .:|||...|:.:||..|.||.|:|:|.|||||:||||||.:::...|.|:.||..|....||.|.
Worm   389 FKTGDVGSLDKDGYLTIGGRSKDMIISGGENIYPKEIEDAIDSIEFVKESAVIAAPHPDFGEAVV 453

  Fly   523 AYVRLEEGVDPASFTAETLKAYAKGKLAHFKVPRYVIPIDAFPKTTSGKIQK 574
            |.|..:..|:......|.|....:.|||.:|||:.||.::..|:....|::|
Worm   454 AVVVPKNMVEDEQKFEEDLIEMLRKKLAKYKVPKKVILLEELPRNHITKVRK 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	143/566 (25%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	106/349 (30%)
acs-21	NP_503845.1	MCS	38..505	CDD:213307	136/534 (25%)
acs-21	NP_503845.1	PRK07514	40..517	CDD:181011	137/534 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R434
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840