DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12512 and acs-6

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_495450.1	Gene:	acs-6 / 174156	WormBaseID:	WBGene00022849	Length:	565	Species:	Caenorhabditis elegans

Alignment Length:	584	Identity:	153/584 - (26%)
Similarity:	242/584 - (41%)	Gaps:	86/584 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 VYRTIGQQLELSASNFGDVEAIVSCH-EGKRYSFKSLLQEADALAAGFRKLGLQPGDAVGLWAPN 108
            |:..|.:...:.||...|....:... ..|:..:|.:....::||....|||.:|||......||
Worm    17 VHERIFEACRIHASANKDAVCFIDAETTTKKKLYKDVEPTVNSLATALVKLGFKPGDVASQAFPN 81

  Fly   109 YLHWYLGMMGAARAGLTSVGLNPAYQGPEIAYCLNKVNVKAIIAPETFKTQNYYEILRDICPE-- 171
            ...:.:.|:...:.|..                  ..|..||...        ||:....|..
Worm    82 CPEFLVAMLAVMKCGGA------------------MSNASAIFTD--------YELQLQFCDSNT 120

  Fly   172 ---ISDAD-TGKIR--SEKFPHLRSVIIDSNDSLKGALRFD--DFLDLASKSEREEVAKMQKSIL 228
               .:|.| ..:||  :.|.|.:|.:|......|:.....:  |:::|....::    .:..::.
Worm   121 SIVFTDEDRLARIRRATAKCPGVRKIICLRTFPLRTEFPENVLDYVELTQTPDQ----PINVNVS 181

  Fly   229 PESACNIQFTSGTTGNPKAACLTHHNF--------------VNNGIHVGNRNELEGERICVQVPM 279
            .:|...:.::|||||.||...|||.|.              |...:....:.....|...:.:|.
Worm   182 MDSIALLPYSSGTTGRPKGCQLTHRNIGAMLDVAKAHLETDVAPAMFGKEKATWHKEHTVLLLPW 246

  Fly   280 FHAFGVIISIMAALTKGATMVLPAAG--FSPKDS---LQAIVNEKCSVIHGTPTMYVDLVNTQKK 339
            :||:|:       .|...|::|...|  |...|:   |..|...|..:....|.|.:.|.   |.
Worm   247 YHAYGL-------NTMFETILLGMTGIVFKKFDTIVMLNRIKFYKVKLAWLVPPMLIFLA---KD 301

  Fly   340 LQVPLGR----IKKAVTGGAIVSPQLIKDVRQVLNVEAVHSVYGLTETTAVIFQSLPGDSSDVVL 400
            ..||:..    :|..::.||....||.::|.:......:...||:||  .|.|.::|........
Worm   302 PMVPIFNTAPFLKVIMSAGATAGKQLCEEVSKRFPNAWLCQAYGMTE--MVQFTTIPRFEDGNCF 364

  Fly   401 NSVGHLTDHIEAKVVDAEGR-CVPFGQPGELCVRGYTTMLGYHDDEEKTKETIGNDRWLRTGDQF 464
            .:||:|....|.|::|.|.: .......|:||.||.|.|.||...||  .:.|..|.:|.|||..
Worm   365 ETVGNLASTYELKILDKEKKEITTINTVGQLCFRGPTVMKGYLKREE--ADIIDKDGFLLTGDLG 427

  Fly   465 VLEANGYGRIVGRLKEMLIRGGENIFPKEIEDFLNAHPQVIEAHVIGVPDERLGEEVCAYVRLEE 529
            .::..|...:.||:||::...|..:.|.||||.|..||:|.:..|||||||..||...||:..::
Worm   428 SIDDKGRIHVTGRIKELIKVNGMQVPPVEIEDVLLLHPKVKDCAVIGVPDEHKGESPKAYIVKKD 492

  Fly   530 GVDPASFTAETLKAYAKGKLAHFK-VPRYVIPIDAFPKTTSGKIQKFKLVE-AFKAKETELKAA 591
                .:.|...|..:.:.||:.:| :..|.. ||:.||..|||||:.||.: |..:..||.:|:
Worm   493 ----HTLTEAELTEFVRQKLSSYKWIDTYEF-IDSIPKLPSGKIQRKKLKKMAESSGSTESEAS 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	153/584 (26%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	111/372 (30%)
acs-6	NP_495450.1	CaiC	15..541	CDD:223395	149/572 (26%)
acs-6	NP_495450.1	Firefly_Luc_like	37..532	CDD:213279	140/543 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X154
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810