DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12512 and acs-16

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_490859.1	Gene:	acs-16 / 171714	WormBaseID:	WBGene00018579	Length:	569	Species:	Caenorhabditis elegans

Alignment Length:	586	Identity:	151/586 - (25%)
Similarity:	255/586 - (43%)	Gaps:	95/586 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 STSMPSLISHKHHIGKDPLVYRTIGQQLELSASNFGDVEAIVSCHEGKRYSFKSLLQEADALAAG 90
            |.::|.||..|..:.:...|:.:  ::|.|                    :|..::.|.::||||
Worm    33 SQTIPQLIYTKSEMDRVAAVFDS--EKLSL--------------------TFSKIVSEMESLAAG 75

  Fly    91 FRKLGLQPGDAVGLWAPNYLHWYLGMMGAARAGLTSVGLNPAYQGPEIAYCLNKV----NVKAII 151
            |..:||:.||.|.:...|:....|..:..:||||.....||.|..   :|.|.:.    ..:.|:
Worm    76 FLSIGLKQGDRVLVAGSNHSQVMLCALACSRAGLVFSLANPNYPN---SYSLKRALELGEFQCIV 137

  Fly   152 APETFKTQNY-----YEILRDICPEISDADTGKIRSEKFPHLRSVIIDSNDSLKGALRF---DDF 208
            .   |:...|     ..:|.:|.||:..:..|:::||..|.|..||:...|. |.|..|   :.|
Worm   138 C---FRAHQYEADHLNNLLLEIAPELMRSRKGQLKSELLPKLTHVILAEEDH-KHAGTFTLSEVF 198

  Fly   209 LDLASKSEREEVAKM---QKSILPESACNIQFTSGTTGNPKAACLTHHNFVN-----------NG 259
            |    ||.:|::||:   .|....:.|| :|||.||||.||...|:|:..:|           |.
Worm   199 L----KSSKEKIAKLPDFSKWSSHKLAC-LQFTLGTTGAPKLIALSHYQMLNGARAVAAAFGIND 258

  Fly   260 IHVGNRNELEGERICVQVPMFH-AFGVIISIMAALTKGATMVLPAAGFSPKDSLQAIVNEKCSVI 323
            .||          :...:|:|. |...:|.:...||: ..::.|.|...||:...::...:|:.:
Worm   259 KHV----------LACALPIFRIAIFNLICLSPFLTE-CRIIFPDATPLPKNLFSSVSKYRCTTL 312

  Fly   324 HGTPTMYVDLVNTQKKLQVPLGRIKKAVTGGAIVSPQLIKDVR-QVLNVEAVHSVYGLTETTAVI 387
            .........|:...:..:|.|..::..:..|..||.:::|.:: |..||:.:...|.||||.::
Worm   313 LSNGAALRLLLKISQTQRVKLSALENILLIGDRVSKEVLKLIKVQAENVKIIAVGYLLTETGSI- 376

  Fly   388 FQSLPGDSSDVVLNSVGHLTDHIEAKVVDAEG--RCVPFGQPGELCVRGY--TTMLGYHDDEEKT 448
              .|.||.:.....:||......||.::..:|  ..|..|:.|:|.:|.|  :|.:||..|
Worm   377 --PLMGDQNSDFTRNVGKAIAGYEAHLIPLDGSENQVETGKLGKLLIRVYYGSTFMGYAPD---- 435

  Fly   449 KETIGNDRWLRTGDQFVLEANGYGRIVGRLKEMLIRGGENIFPK--EIEDFLNAHPQVIEAHVIG 511
              |.|.::|:.|||...::.||...:|.. ::.||....|...:  .:|..||.:..:....|:
Worm   436 --TKGKEKWVDTGDIGRMDENGAIEVVAS-EDDLIYDKNNCLVEHWNLERLLNQNDLIKGVQVV- 496

  Fly   512 VPDERLGEEVCAYVRLEEGVDPASFTAETLKAYAKGKLAHFKVPRYVIPIDAFPKTTSGKIQKFK 576
              ....|:.|.|..........|:...:.||:..:..  ||..|.....:|.||:..: |||||:
Worm   497 --SRGRGQPVTAVCVARSTQFHAAKLKDELKSMCRSH--HFVAPDVFAFVDDFPRVHT-KIQKFR 556

  Fly   577 L 577
            :
Worm   557 I 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	146/569 (26%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	94/366 (26%)
acs-16	NP_490859.1	CaiC	35..565	CDD:223395	150/584 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.815465	Normalized mean entropy	S2257
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004397
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43201
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.820