DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12512 and acs-13

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001293196.1	Gene:	acs-13 / 171643	WormBaseID:	WBGene00022037	Length:	726	Species:	Caenorhabditis elegans

Alignment Length:	605	Identity:	155/605 - (25%)
Similarity:	251/605 - (41%)	Gaps:	134/605 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 SFKSLLQEADALAAGFRKLGLQPGDA--VGLWAPNYLHWYLGMMGAARAGLTSVGLNPAYQ--GP 136
            |:.::|:.||.::..||:||:..|:|  :|:::.|...|.:...  |....::| :.|.|:  |.
Worm   152 SYNTILERADNVSVAFRELGVPTGNAENIGIYSKNRAEWIITEF--ATYNYSNV-IVPIYETLGS 213

  Fly   137 EIA-YCLNKVNVKAIIAPETFKTQNYYEILRDICPEISDADTGKIR-SEKFPHLRSVII--DSND 197
            |.: :.||:..:|.:                 :|.:||.| ||.:: .|:.|.|.::::  ...|
Worm   214 EASIFILNQAEIKIV-----------------VCDDISKA-TGLLKFKEQCPSLSTLVVMEPVTD 260

  Fly   198 SLK--------GALRFDDFLDLASKSEREEVAKMQKSILPESACNIQFTSGTTGNPKAACLTHHN 254
            .||        ..|.|:| |:...|:.:...|.:..:  ||....|.:||||||.||...|||.|
Worm   261 ELKTTASSLGVEVLTFED-LEKIGKNAKTRPAHIPPT--PEDLATICYTSGTTGTPKGVMLTHAN 322

  Fly   255 FVNNGI------HVG----------------NRNELEGERICVQVPMFHAFGVIISIMAALTKGA 297
            .:.:|:      |.|                ....:|....||...:....|.|..:...:.:..
Worm   323 VIADGVCMDFFKHSGIAATDSMISFLPLAHMLERVIESVCFCVGAKVGFYRGDIRVLAEDIKELK 387

  Fly   298 TMVLPAAGFSPK------DSLQAIVNEKC--SVIHGTPTMYV--DLVNTQ------------KKL 340
            ..|:|..   |:      |.:.:.||:..  .::......|.  |:.|..            ||:
Worm   388 PTVVPVV---PRVLNRLYDKVMSEVNKSTLKKMLFDFAISYKARDMANFNIRNDGFFDNLVFKKI 449

  Fly   341 QVPL-GRIKKAVTGGAIVSPQLIKDVRQVLNVEAVHSVYGLTETTAVIFQSLPGDSSDVVLNSVG 404
            :... ||::..:||.|.:|..::..||..:....|.. ||.||..|....|:.|||   :...||
Worm   450 REGFGGRVRLMITGSAPLSTNVLTFVRAAMGCVVVEG-YGQTECVAACTVSMEGDS---LAGHVG 510

  Fly   405 HLTDHIEAKVVDA-EGRCVPFGQPGELCVRGYTTMLGYHDDEEKTKETIGNDRWLRTGDQFVLEA 468
            .:....:.|:||. |.......|.||:||:|:....||:.:|::|||||..|.||.|||......
Worm   511 MVIPSCQIKLVDVPELNYYAKDQAGEVCVKGHIIFKGYYKNEQQTKETIDEDGWLHTGDIGRWTP 575

  Fly   469 NGYGRIVGRLKEML-IRGGENIFPKEIEDFLNAHPQVIEAHVIG-----------VPDERLGEEV 521
            .|..:||.|.|.:. :..||.:.|::||:.......|.::.|.|           |||    .||
Worm   576 EGTLKIVDRKKHIFKLSQGEYVAPEKIENIYVRSKYVAQSFVHGESLKTCLIAIVVPD----AEV 636

  Fly   522 CAYVRLEEGVDPASFTAETL-------KA-----YAKGK---LAHFKVPRYV-IPIDAFPKTTSG 570
            ......::|:   ..|.|.|       ||     .|.||   |..|:..|.: :..:.|
Worm   637 LVPAMADQGI---KGTFEELCNNDAVKKAILDDMVAVGKKAGLFSFEQVRDISLSAEQF------ 692

  Fly   571 KIQKFKLVEAFKAKETELKA 590
            .::...|....|:|..:|||
Worm   693 SVENDLLTPTLKSKRPKLKA 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	155/605 (26%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	109/421 (26%)
acs-13	NP_001293196.1	LC-FACS_euk	147..723	CDD:341250	155/605 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910