DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12512 and AgaP_AGAP001473

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	XP_321651.4	Gene:	AgaP_AGAP001473 / 1281701	VectorBaseID:	AGAP001473	Length:	672	Species:	Anopheles gambiae

Alignment Length:	583	Identity:	125/583 - (21%)
Similarity:	211/583 - (36%)	Gaps:	122/583 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 KRYSFKSLLQEADALAAGFRKLGLQPGDAVGLWAPNYLHWYLGMMGAARAGLTSVGLNPAYQGPE 137
            :..::..|..:...||.|.|:||:|.||.|.::.|......:.|:..||.|.....:...:...|
Mosquito   113 RHVTYNELYDKVSRLAGGLRRLGVQKGDRVVIYMPLIPEAIIAMLATARLGAVHSVVFGGFAASE 177

  Fly   138 IAYCLNKVNVKAIIAP----ETFKTQNYYEILRDICPEISDADTGKIRSEKFPHLRSVIIDSNDS 198
            :...:.....|.|||.    |..|...|.:||.:           .:...::...:::|....:.
Mosquito   178 LCTRIEHAEPKVIIAANCGVEPHKIIYYLDILHE-----------AVAMSRWKPAKNIIYRRANI 231

  Fly   199 LKGALRFDDFLDLASKSEREEVAKMQKSILPESACNIQFTSGTTGNPKAACLTHHNFVNNGIHVG 263
            |...|  |:..|:|.::..:.|......:.......|.:|||||..||                |
Mosquito   232 LMSDL--DETWDIAWENALDTVPVDCVPVEANDPLYILYTSGTTDKPK----------------G 278

  Fly   264 NRNELEGERICVQVPMFHAFGV--------------IIS----IMAALTKGATMVL----PAAGF 306
            .:..:.|..:.:...|...:|:              ::.    ....|..|||.|:    |....
Mosquito   279 IQRPIGGHLVTLMYTMNTIYGLQQDDVWWNASDLGWVVGHSYICYGPLLYGATSVMYEGKPDRTP 343

  Fly   307 SPKDSLQAIVNEKCSVIHGTPTMY-----VDLVNTQKKLQVPLGRIKKAVTGGAIVSPQLIKDVR 366
            .|....:.|...|.|.:...||.:     ||...|..: :..|..::.....|.....:.:|.:|
Mosquito   344 DPGQYFRIIDQHKVSAVFSVPTAFRVIRRVDPDVTYGR-KYSLKSLRAIFIAGEHCDLETMKWMR 407

  Fly   367 QVLNVEAVHSVYGLTETTAVIFQSLPGDSSDV-----------------VLNSVGHLTDHIEAKV 414
            :...|..::. :..|||.:.|..:..|.:.::                 ||:..||     |||.
Mosquito   408 KTFKVPVLNQ-WWQTETGSAITATCVGFAQNLQTPPFTTGLPYCGYDIYVLDKNGH-----EAKP 466

  Fly   415 VDAEGRCV---PFGQPG---------ELCVRGYTTML-GYHDDEEKTKETIGNDRWLRTGDQFVL 466
            .:. ||.|   |. .||         ||..:.|.... ||:|                |.|....
Mosquito   467 NEL-GRIVVKLPL-PPGNMATLYRSDELFRKTYFQRFPGYYD----------------TMDAGYK 513

  Fly   467 EANGYGRIVGRLKEMLIRGGENIFPKEIEDFLNAHPQVIEAHVIGVPDERLGE-EVCAYVRLEEG 530
            :.|||..:..|..:::...|..|....:||.:..||.|.:|.|.|||:...|: .:|.||.....
Mosquito   514 DENGYIYVTARDDDVINVAGHRISTSSLEDAILRHPDVADAAVFGVPEPTKGQIPLCLYVTKANV 578

  Fly   531 VDPAS-FTAETLKAYAK--GKLAHFKVPRYVIPIDAFPKTTSGKIQKFKLVEAFKAKETELKA 590
            ..||: .:.|.:....:  |.:|.||:   ...:.:.|:|.|||..:..:.:....|...:.|
Mosquito   579 SKPAAKMSVELINIIREVIGPIAAFKL---AAQVQSLPRTRSGKTLRKAMADLAANKHITIPA 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	125/583 (21%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	90/408 (22%)
AgaP_AGAP001473	XP_321651.4	prpE	32..655	CDD:182517	125/583 (21%)
AgaP_AGAP001473	XP_321651.4	AFD_class_I	41..649	CDD:302604	125/583 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910