DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12512 and AgaP_AGAP009159

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	XP_319920.4	Gene:	AgaP_AGAP009159 / 1280115	VectorBaseID:	AGAP009159	Length:	570	Species:	Anopheles gambiae

Alignment Length:	578	Identity:	133/578 - (23%)
Similarity:	240/578 - (41%)	Gaps:	80/578 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SMPSLISHKHHIGKDPL--VYRTIGQQLELSASNFGDVEAIVSCHEGKRYSFKSLLQEADALAAG 90
            |:||:::....||:..|  :.|:..:.::::|    |.....:|.|.:|...:        :|..
Mosquito    16 SLPSVLNPAAGIGRIVLDVLARSPDRVIQINA----DTGRQTTCGEMRRRIVR--------VALH 68

  Fly    91 FRKLGLQPGDAVGLWAPNYLHWYLGMMGAARAGLTSVGLNPAYQGPEIAYCLNKVNVKAIIAPET 155
            .|:||.:.||.|.|...|.......::|....||....|.|.::..:..:.:.:.....:..
Mosquito    69 LRRLGYRRGDFVSLACGNGEQVVPVLIGCWVLGLAVNPLAPVFEKADFVHMMKQTQSGLVFC--- 130

  Fly   156 FKTQNYYEILRDICPEISDADTGKIRS---EKFPHLRSVIIDSNDSLKGALR-FDDFLDLASKSE 216
                             ..|:.|.:|.   |...| .:.:.....:.:|..| .|:.|:.....|
Mosquito   131 -----------------DPANAGVVREAVHEAITH-GAQLFAMGPAAEGVHRSVDELLEPIDGEE 177

  Fly   217 --REEVAKMQKSILPESACNIQFTSGTTGNPKAACLTHHNFVNNGIHVGNRNELEGERICVQVPM 279
              |.|.......:|....|    :|||||.||..||:|.:|:.....|...::.....|.....:
Mosquito   178 CFRAEYLGDASKLLAMVLC----SSGTTGLPKGVCLSHAHFILIDRSVPYCSDASDGPIFNFSSL 238

  Fly   280 FHAFGVIISIMAALTKGATMVLPAAGFSPKDSLQAIVNEKCSVIHGTPTMYVD-LVNTQKKLQVP 343
            |.|.| |.::|.:|......||.:..:.|...|..|...:...:. ||..||. |:...:..:..
Mosquito   239 FWATG-IFAVMTSLLHSRPRVLTSKPYQPDLLLDLIETYRIENLF-TPPSYVSTLLAHPRTDRAD 301

  Fly   344 LGRIKKAVTGGAIVSPQLIKDVRQVLNVEAVHSVYGLTETTAVIFQSLPGDSSDVVL--NSVGHL 406
            |..:::...||:.|..::...::::|......|:||.:|...:       ..:||.:  .|||.|
Mosquito   302 LSSVRQWQLGGSRVPTEMTLRLQKLLPQGHTRSIYGSSEIGFI-------TRNDVTVKPGSVGPL 359

  Fly   407 TDHIEAKVVDAEGRCVPFGQPGELCVRGYTTMLGYHDDEEKTKETIGNDRWLRTGDQFVLEANGY 471
            |.:::.:|:|.:|:.|..|..|||.:|.....|||..:.|.|...:..|.:.|:||...::|:|.
Mosquito   360 TTNVQCRVLDEDGQPVGVGVAGELVLRHRYMFLGYLHNPEATANALTEDGFFRSGDIGYIDADGS 424

  Fly   472 GRIVGRLKEMLIRGGENIFPKEIEDFLNAHPQVIEAHVIGVP-------------DERLGEEVCA 523
            ..:|.|:|:::......:.|.::|..:.....|.:..|||||             :.::|
Mosquito   425 LYVVDRIKDIIKYNNYQVSPSDLECIIQRMDGVKQVCVIGVPAPDGSSDLPMAVVERKVG----- 484

  Fly   524 YVRLEEGVDPASFTAETLKAYAKGKLAHFKVPRYVIP-IDAFPKTTSGKIQKFKLVEA 580
                ..|...|....|.:..:.:.::|.||..|..:. :|:||.|.||||.:..:.:|
Mosquito   485 ----GGGGGAAPLREEDIVRHVEEQVADFKRLRGGVRFVDSFPMTPSGKILRLAVRKA 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	128/563 (23%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	93/364 (26%)
AgaP_AGAP009159	XP_319920.4	CaiC	6..541	CDD:223395	133/578 (23%)
AgaP_AGAP009159	XP_319920.4	AFD_class_I	43..531	CDD:302604	124/542 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810