DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12512 and AgaP_AGAP004655

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	XP_316739.3	Gene:	AgaP_AGAP004655 / 1277297	VectorBaseID:	AGAP004655	Length:	548	Species:	Anopheles gambiae

Alignment Length:	545	Identity:	155/545 - (28%)
Similarity:	242/545 - (44%)	Gaps:	49/545 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 TIGQQLELSASNFGDVEAIVSCHEGKRYSFKSLLQEADALAAGFRKL-GLQPGDAVGLWAPNYLH 111
            ::|..|.......||..|::.........:..||:.|..||.|.|.| .:.|...||:.:.|.|.
Mosquito    27 SLGMYLMKRLLRHGDGVAVIDGVYSNELRYLELLENAVRLAEGLRSLTDVTPNGVVGIISENRLE 91

  Fly   112 WYLGMMGAARAGLTSVGLNPAYQGPEIAYCLNKVNVKAIIAPETFKTQNYYEILRDICPEISDAD 176
            :.:.:..:.........:|..|...|..:.|| ::..:|:....:..:....:.|
Mosquito    92 FPVVLYASFFVNAAVAPINLTYTEREFDHALN-LSKPSILFVSPYSAERVIAVAR---------- 145

  Fly   177 TGKIRSEKFPHLRSVIIDSNDSLKGA--LRFDDFLDLASKSEREEVAKMQKSILPESACNIQFTS 239
                ::..|  ::.:.:..|::..||  :.|:||| |.:.:......::..:.:.|....|..:|
Mosquito   146 ----KNRHF--IKHIFLFGNENSFGADVVLFNDFL-LQTSAINPYSFQVAPTNVEEHVALIMCSS 203

  Fly   240 GTTGNPKAACLTHHNFVNNGIHVGNRNELEGE-----RICVQVPMFHAFGVIISIMAALTKGATM 299
            ||||.||...||..|.:.:   |...:.||..     .:...:|.|||||.:..|.....|...:
Mosquito   204 GTTGLPKGVQLTQRNVIAS---VSLLSVLEASFEVPVVVLGVIPWFHAFGCLTLINVICNKLKLV 265

  Fly   300 VLPAAGFSPKDSLQAIVNEKCSVIHGTPTMYVDLVNTQKKLQVPLGRIKKAVTGGAIVSPQLIKD 364
            .||.  |.....|..|.|.:||.:...|.:.|.|..........|..|...:.|.|.:|.:....
Mosquito   266 SLPK--FEEGLFLSCIENYRCSFVFVVPPLMVFLAKHPLVDNYDLSCINTLLCGAAPLSKETEML 328

  Fly   365 VRQVLNVEAVHSVYGLTETT-AVIFQSLPGDSSDVVLNSVGHLTDHIEAKVVDAE-GRCVPFGQP 427
            |::.:.|:.|...||::||| |::.||...:.|    .|||.|.....|||||.| ||.:...:.
Mosquito   329 VKKRIGVKHVLQGYGMSETTLAMLIQSNDSNKS----GSVGKLQAGTMAKVVDVETGRLLGPNEA 389

  Fly   428 GELCVRGYTTMLGYHDDEEKTKETIGNDRWLRTGDQFVLEANGYGRIVGRLKEMLIRGGENIFPK 492
            |||..:|...|.||..:|::|.:||..|.||||||....:.:....|:.||||::...|..:.|.
Mosquito   390 GELYFKGTQIMKGYIGNEQETIQTIDKDGWLRTGDIGYYDNDEEFFIIDRLKELIKYKGYQVPPA 454

  Fly   493 EIEDFLNAHPQVIEAHVIGVPDERLGEEVCAYVRLEEGVDPASFTAETLKAY-----AKGKLAHF 552
            |||..|..:.::.:|.|:|.|||..||...|:|..:.||   :.|.|.:|.|     :..|..|.
Mosquito   455 EIEAVLLTNSKIKDAGVVGFPDEAAGELPLAFVVKQPGV---TLTEEEVKQYVAARTSPAKRLHG 516

  Fly   553 KVPRYVIPIDAFPKTTSGKIQKFKL 577
            .| |:|..|   ||..||||.:.:|
Mosquito   517 GV-RFVSEI---PKNVSGKILRREL 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	155/545 (28%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	120/359 (33%)
AgaP_AGAP004655	XP_316739.3	PLN02246	27..541	CDD:215137	155/545 (28%)
AgaP_AGAP004655	XP_316739.3	Firefly_Luc_like	44..533	CDD:213279	149/522 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810