DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12512 and AgaP_AGAP008557

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	XP_314666.4	Gene:	AgaP_AGAP008557 / 1275423	VectorBaseID:	AGAP008557	Length:	594	Species:	Anopheles gambiae

Alignment Length:	597	Identity:	316/597 - (52%)
Similarity:	429/597 - (71%)	Gaps:	20/597 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SKLQTISRYMLRQKCAFN----SMRSISTSMPSLI-----SHKHHIGKDPLVYRTIGQQLELSAS 58
            :.|:.::.|..::...::    |:|:.||....:.     |:.||||..|||||.:||.|.::|.
Mosquito     2 ASLRLLAHYQYQRAAWYSRVLQSIRTQSTDASGVAHEKAQSYVHHIGSKPLVYRNVGQHLRMAAE 66

  Fly    59 NFGDVEAIVSCHE-GKRYSFKSLLQEADALAAGFRKLGLQPGDAVGLWAPNYLHWYLGMMGAARA 122
            .|.:.|||||||| |.|.::.::|.:.|.|||.|.:|||:.||.||:||||...:||..:.||||
Mosquito    67 RFPNNEAIVSCHEAGARLTYAAVLDKVDGLAAAFHQLGLRQGDRVGIWAPNGTLFYLTNLAAARA 131

  Fly   123 GLTSVGLNPAYQGPEIAYCLNKVNVKAIIAPETFKTQNYYEILRDICPEISDADTGKIRSEKFPH 187
            |:.:||:|||||.||:.|.|.||.|||::|.|.::.||||.::..|.||::.:..|:::|:..|.
Mosquito   132 GMITVGINPAYQVPELEYALQKVGVKALVAAEGYRQQNYYGMISHIAPELASSKPGELKSKALPE 196

  Fly   188 LRSVIIDSNDSLKGALRFDDFLDLASKSEREEVAKMQKSILPESACNIQFTSGTTGNPKAACLTH 252
            |.:|||||..||.||::|.:..::.|:....::..:|..|:|:|..|:||||||||:||||.::|
Mosquito   197 LSAVIIDSQKSLPGAIKFSELFEVPSEQAISKIEMLQSKIMPDSGVNLQFTSGTTGHPKAALMSH 261

  Fly   253 HNFVNNGIHVGNRNELEG--ERICVQVPMFHAFGVIISIMAALTKGATMVLPAAGFSPKDSLQAI 315
            ..|||||:|:|||||::.  .|:|||||:|||||::|:|||||:.|:|:|||.|||...|||.||
Mosquito   262 FGFVNNGLHIGNRNEMDQRMHRLCVQVPLFHAFGMVIAIMAALSYGSTLVLPTAGFKAADSLAAI 326

  Fly   316 VNEKCSVIHGTPTMYVDLVNTQKKLQVPLGRIKKAVTGGAIVSPQLIKDVRQVLNVEAVHSVYGL 380
            |.|:||::.||||||||||....:....|...:.||||||..||:|..|::..|.|..|.:|:|:
Mosquito   327 VRERCSIVLGTPTMYVDLVRRIVESGAKLDSPEIAVTGGATCSPKLFADIKHTLGVRKVKTVFGM 391

  Fly   381 TETTAVIFQSLPGDSSDVVLNSVGHLTDHIEAKVVDAEGRCVPFGQPGELCVRGYTTMLGYHDDE 445
            |||||||||||..:|.:.|..:|||:|||.||||:|.:|..||||..||||||||.|||||..||
Mosquito   392 TETTAVIFQSLFEESPEDVQQTVGHVTDHYEAKVIDRDGHIVPFGTAGELCVRGYGTMLGYWGDE 456

  Fly   446 EKTKETIGNDRWLRTGDQFVLEANGYGRIVGRLKEMLIRGGENIFPKEIEDFLNAHPQVIEAHVI 510
            :||||||..||||||||||:|..:|||:|||||||::|||||||:|||:||:||.:|:::|.|.|
Mosquito   457 KKTKETIAADRWLRTGDQFMLREDGYGKIVGRLKEVVIRGGENIYPKEVEDYLNTYPKILEVHCI 521

  Fly   511 GVPDERLGEEVCAYVRL---EEGVDPASFTAETLKAYAKGKLAHFKVPRYVIPIDAFPKTTSGKI 572
            ||||||.|||:||||||   ||.:|     .|.:..|.:||||::|||:||..::..|||||||:
Mosquito   522 GVPDERTGEELCAYVRLKDPEETID-----REEIMRYCEGKLAYYKVPKYVRVLNDLPKTTSGKV 581

  Fly   573 QKFKLVEAFKAK 584
            |||||.:.|.|:
Mosquito   582 QKFKLAQLFAAE 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	305/548 (56%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	215/352 (61%)
AgaP_AGAP008557	XP_314666.4	PRK08315	40..593	CDD:236236	309/557 (55%)
AgaP_AGAP008557	XP_314666.4	FACL_like_2	238..587	CDD:213284	216/353 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	485	1.000	Domainoid score	I1344
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23519
Inparanoid	1	1.050	634	1.000	Inparanoid score	I2214
OMA	1	1.010	-	-		QHG62430
OrthoDB	1	1.010	-	-		D355104at33208
OrthoFinder	1	1.000	-	-		FOG0004397
OrthoInspector	1	1.000	-	-		oto110029
Panther	1	1.100	-	-	LDO	PTHR43201
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X154
TreeFam	1	0.960	-	-
	13	12.940