DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12512 and AgaP_AGAP008544

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	XP_557683.3	Gene:	AgaP_AGAP008544 / 1275412	VectorBaseID:	AGAP008544	Length:	561	Species:	Anopheles gambiae

Alignment Length:	579	Identity:	131/579 - (22%)
Similarity:	243/579 - (41%)	Gaps:	79/579 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SLISHKHHIGK--DPLVYRTIGQQLELSASNFGDVEAIVSCHEGKRYSFKSLLQEADALAAGFRK 93
            |:.:.|.::|:  :.::.||..:.:::..    |..:.:||.|.:....:......|   .|.||
Mosquito    20 SIYNPKANVGEVLNHILLRTPERIIQIDM----DTGSRLSCAEFRMRMVRFAQHLTD---VGLRK 77

  Fly    94 -----------------LGLQPGDAVGLWAPNYLHWYLGMMGAARAGLTSVG-----LNPAYQGP 136
                             :||:.||.|.:...|..:     :......|.::|     |.|.:...
Mosquito    78 GDIFRMRMVRFAQQLTDVGLRKGDIVAMANGNSEN-----VAPLACALMTLGAPFNPLAPGFNVE 137

  Fly   137 EIAYCLNKVNVKAIIAPETFKTQNYYEILRDICPEISDADTGKIRSEKFPHLRSVIIDSNDSLKG 201
            ::|:.|.....|.:     |...:..|::|.....:.|   |:|....|...|       |.:|.
Mosquito   138 DMAHMLRLTQPKMV-----FCDDDNVEVVRQAVCSVLD---GEIPIYVFESQR-------DDVKH 187

  Fly   202 ALRFDDFLDLASKSEREEVAKMQKSILPESACNIQFTSGTTGNPKAACLTHHNFVNNGIHVGNRN 266
            |   :|.|....|.|:.........:|....|    :|||||.||..|:||...|:.   :|...
Mosquito   188 A---EDLLIPTGKEEQPTHLGDSHELLSMILC----SSGTTGPPKGVCVTHAQTVST---IGCYP 242

  Fly   267 ELEGERICVQVPMFHAFGVIISIMAALTKGATMVLPAAGFSPKDSLQAIVNEKCSVIHGTPTMYV 331
            ..:...:....|::...||.: :::..:..:|.::....||.:...:|:...:.:.:...|:...
Mosquito   243 TAKPATVFNFSPLYWGTGVYM-MLSTFSGSSTRLITRRPFSEETFFEAVEKHRANFVFMPPSYAS 306

  Fly   332 DLVNTQKKLQVPLGRIKKAVTGGAIVSPQLIKDVRQVLNVEAVHSVYGLTET--TAVIF-QSLPG 393
            .::..::..||....:.....||:.||..|......:|.....::..|.:|.  .|..| :..||
Mosquito   307 QVLRHERTSQVDFSSLIMLAIGGSYVSEGLRDRFDLLLPNGRTYNTVGTSEVGWVATDFAKRKPG 371

  Fly   394 DSSDVVLNSVGHLTDHIEAKVVDAEGRCVPFGQPGELCVRGYTTMLGYHDDEEKTKETIGNDRWL 458
                    |||....::..|:||.:|..:..|:.|::.::|....:||:.:||.|:.||....::
Mosquito   372 --------SVGTPVVNVSVKIVDDDGNDLGVGERGQVLLKGAEPFIGYYKNEEATRATIDERGFM 428

  Fly   459 RTGDQFVLEANGYGRIVGRLKEMLIRGGENIFPKEIEDFLNAHPQVIEAHVIGVP--DERLGEEV 521
            |:||...::..||..::.|.|::....|.::.|.|:|..:.....|:|..|:.||  :||..|..
Mosquito   429 RSGDIGYVDEEGYLYLIDREKDIFKYRGFHVSPSELEGVVGQIEGVMEVCVVAVPADEERTTELP 493

  Fly   522 CAYVRLEEGVDPASFTAETLKAYAKGKLAHFKVPR-YVIPIDAFPKTTSGKIQKFKLVE 579
            .|.:....|   :..|||.:.....||::.||..| .|..::..|||.:||..:.|::|
Mosquito   494 TAVIVRAAG---SPLTAEQVMKVVDGKVSDFKRLRGGVYFVERLPKTQTGKNVRRKVLE 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	128/565 (23%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	87/353 (25%)
AgaP_AGAP008544	XP_557683.3	CaiC	22..548	CDD:223395	129/574 (22%)
AgaP_AGAP008544	XP_557683.3	AFD_class_I	44..541	CDD:302604	122/545 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810