DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12512 and AgaP_AGAP002718

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	XP_312208.4	Gene:	AgaP_AGAP002718 / 1273249	VectorBaseID:	AGAP002718	Length:	600	Species:	Anopheles gambiae

Alignment Length:	565	Identity:	161/565 - (28%)
Similarity:	246/565 - (43%)	Gaps:	69/565 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 PLVYRTIGQQLELSASNFGDVEAIVSCHEGKRYSFKSLLQEADALAAGF-RKLGLQPGDAVGLWA 106
            |:.:.|:...|....|.:.:..|:|....|:.|::.:|.....|||... |||.|..|..:.:..
Mosquito    69 PVPHVTLDHYLWDQFSQWANKTAVVCGITGRNYTYGTLRDHCAALAIRLQRKLHLNFGQTLAVCL 133

  Fly   107 PNYLHWYLGMMGAARAGLTSVGLNPAYQGPEIAYCLNKVNVKAIIAPETFKTQNYYEILRDICPE 171
            ||...:.|...|...|||....:||.|...||:..|...:.|.:|.     ..:.|.:||:...:
Mosquito   134 PNIPEFPLVTFGGIEAGLVVTTINPIYTAEEISRQLVDSDAKVLIG-----LASNYAVLREAAQQ 193

  Fly   172 IS-DADTGKIR---SEKFPHLRSVIIDSNDSLKGALRFDDFLDLASKSEREEVAKMQKSILPESA 232
            .. |.....||   .|..|             .||:   ||.:|::..........|.....:..
Mosquito   194 AKRDIPIVCIRCTNDESLP-------------AGAI---DFAELSNPKGIHYSELRQHDRTADDI 242

  Fly   233 CNIQFTSGTTGNPKAACLTHHNFVNN----GIHVGN-------RNELEGERICVQVPMFHAFGVI 286
            ..:.::|||||.||...|||.|.|:|    .:..||       .:..:....|| :|.||.:|:.
Mosquito   243 VFLPYSSGTTGMPKGVELTHLNIVSNSEMLAVKAGNGTVVLPTTDTFQDVLPCV-LPFFHIYGLT 306

  Fly   287 ISIMAALTKGATMV-LPAAGFSPKDSLQAIVNEKCSVIHGTPTMYVDLVNTQKKLQVPLGRIKKA 350
            :::::.|.:|..:| ||  .|.|...|.|:...|.:|:|..|.:.:.|.:...........|:..
Mosquito   307 VTMISKLRQGCKLVTLP--NFKPDTFLNALAEHKGTVLHLVPPIIIFLGHHDGVKPRHTDSIRNV 369

  Fly   351 VTGGA-IVSPQLIKDVRQVLNVEAVHSVYGLTETTAVIFQSLPGDSSDVVLNSVGHLTDHIEAKV 414
            .:|.| :.:|...:...:..|.|.:.. ||||||..|:.....|..:   ..|||......:||:
Mosquito   370 FSGAAPMGTPDAERFTARAPNAEFIQG-YGLTETAPVVLMGALGSRN---YASVGSPCPRTQAKI 430

  Fly   415 VDAE---GRCVPFGQPGELCVRGYTTMLGYHDDEEKTKETIGNDRWLRTGD--------QFVLEA 468
            ||..   ...:...|.|||.|||...|.|||::.:.|.|.|....||||||        ||.
Mosquito   431 VDLNDPTNTALGPNQSGELLVRGPQVMKGYHNNRKATDEMIIEGGWLRTGDIAHYDEQLQFY--- 492

  Fly   469 NGYGRIVGRLKEMLIRGGENIFPKEIEDFLNAHPQVIEAHVIGVPDERLGEEVCAYVRLEEGVDP 533
                 |..||||::...|..:.|.|:|:.|.:|..|.:|.|:|:|....||...|:|..:.|
Mosquito   493 -----ITDRLKELIKVKGFQVPPAELEELLRSHEAVADAAVVGMPHPVAGEVPRAFVVPKAG--- 549

  Fly   534 ASFTAETLKAYAKGKLAHFK-VPRYVIPIDAFPKTTSGKIQKFKL 577
            |..:.:.|||:...|:|.:| :...|..:|:.||..||||.:.:|
Mosquito   550 ARVSEDALKAFIAEKVAVYKRLEGGVTFLDSIPKNASGKILRRQL 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	161/565 (28%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	114/372 (31%)
AgaP_AGAP002718	XP_312208.4	PLN02246	68..595	CDD:215137	161/565 (28%)
AgaP_AGAP002718	XP_312208.4	AFD_class_I	97..590	CDD:302604	153/531 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X154
TreeFam	0	0.000	Not matched by this tool.
	2	1.910