DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12512 and AgaP_AGAP013466

DIOPT Version :9

Sequence 1:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	XP_003436490.1	Gene:	AgaP_AGAP013466 / 11176154	VectorBaseID:	AGAP013466	Length:	538	Species:	Anopheles gambiae

Alignment Length:	551	Identity:	150/551 - (27%)
Similarity:	253/551 - (45%)	Gaps:	51/551 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 TIGQQLELSASNFGDVEAIVSCHEGKRYSFKSLLQEADALAAGFRKLGLQPGDAVGLWAPNYLHW 112
            ::|:.:.......||..|.:.....:::::..:|:.:..||..|.:||::....|.:...|.:..
Mosquito    24 SLGELIIKRLKENGDGIAFIDGVTDEKFTYADVLERSVRLANRFHRLGIKKDTVVAVMCENRIEL 88

  Fly   113 YLGMMGAARAGLTSVGLNPAYQGPEIAYCLNKVNVKAIIA-PETFKTQNYYEILRDICPEISDAD 176
            .:....|.......:.|||.|...|:|:.|.....:||.| |....|      |:.:...:....
Mosquito    89 PIVSFAATYLRAIPILLNPGYTATELAHVLKYSQPRAIFASPLAMAT------LQPLLRTVPSIK 147

  Fly   177 TGKIRSEKFPHLRSVIIDSNDSLKGALRFDDFLDLASKSEREEVA-KMQKSILPESACNIQFTSG 240
            ...:..:|.||.:..:               |.:|..::..:.:: ..|.:.||:....:..:||
Mosquito   148 LTVLFGDKKPHPKVTL---------------FSELFDRNRAQYISFTPQPAKLPDQVGLMVLSSG 197

  Fly   241 TTGNPKAACLTHHNFVNNGIHV-GNRNELEGERICV-QVPMFHAFGVIISIMAALTKGATMVLPA 303
            |||.|||..|||||.:....:: .|.:.:..|:|.: .:|.||.:|.::.:.:.:.|...:.||.
Mosquito   198 TTGLPKAVQLTHHNIMCVLAYMRENASVIPFEQISLGLLPFFHVYGYMVLMHSLINKRVVVSLPR 262

  Fly   304 AGFSPKDSLQAIVNEKCSVIHGTPTMYVDLVNTQKKLQVPLGRIKKAVTGGAIVSPQL-IKDVRQ 367
              |.|...|..|...:.::....|.:.|.|.......:..|..:.....|.|.:|.:| :..:::
Mosquito   263 --FEPTLFLSTIQKYRVTIASLAPPLMVFLAKHPLVDKYDLSSLVFIGCGAAPLSKELELAVMKR 325

  Fly   368 VLNVEAVHSVYGLTETTAVIFQSLPGDSSDVVLNSVGHLTDHIEAKVVDAE-GRCVPFGQPGELC 431
            :.:::.:...|||:||:.    .:...:|| |..|||.:......||||.: ||.:...|.||:|
Mosquito   326 LPHLQMILVGYGLSETSL----GVTTRASD-VHGSVGKVNKLSWLKVVDVKTGRTLGPHQTGEIC 385

  Fly   432 VRGYTTMLGYHDDEEKTKETIGNDRWLRTGD--QFVLEANGYGRIVGRLKEMLIRGGENIFPKEI 494
            |:|...|.||..:|.:|:..|..|.||.|||  .|..:.|.|  ||.|:|:::...|..:.|.|:
Mosquito   386 VKGPLVMKGYLHNERETRAMIDRDGWLHTGDTGYFDEDENFY--IVDRIKDLIKYKGFQVPPAEV 448

  Fly   495 EDFLNAHPQVIEAHVIGVPDERLGEEVCAYVRLEEGV-----DPASFTAETLKAYAKGKLAHFKV 554
            |..|..||.:.:..|:|.||...|:...|:|.|:.|.     :...:.||.|   :|.|..|..|
Mosquito   449 EAVLLTHPGIKDCAVVGRPDAAAGQLPVAFVVLQPGAKLTEPEVQQYVAERL---SKQKQLHGGV 510

  Fly   555 PRYVIPIDAFPKTTSGKIQKFKLVEAF-KAK 584
             |:|..|   |||.||||.:.:||..| |||
Mosquito   511 -RFVHEI---PKTASGKILRRELVALFPKAK 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	150/551 (27%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	111/358 (31%)
AgaP_AGAP013466	XP_003436490.1	PLN02246	24..538	CDD:215137	150/551 (27%)
AgaP_AGAP013466	XP_003436490.1	Firefly_Luc_like	41..525	CDD:213279	140/520 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X154
TreeFam	0	0.000	Not matched by this tool.
	3	2.810